Small diameter blood vessel prostheses from blends of polyethylene oxide and polypropylene oxide

J.G.F. Bots, L. van der Does, A. Bantjes

Research output: Contribution to journalArticleAcademic

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Abstract

Studies on the relationship between blood platelet adhesion and type and amount of polyether segments in copolyetherurethanes report a reduced platelet adhesion with increasing polyether content. We therefore assumed that combinations of polyethylene oxide (PEO) and polypropylene oxide (PPOX) might give materials with a good blood compatibility. Water-soluble PEO was attached to PPOX by u.v.-initiated crosslinking. Films were tested for hydrophilicity, mechanical properties, protein adsorption and blood compatibility. The hydrophilicity was determined by swelling experiments. A compromise between hydrophilicity (PEO) and mechanical strength (PPOX) was met at a swelling of 0.5 (PPOX/PEOratio: 90/10). In protein adsorption studies only small amounts of adsorbed proteins were found. Three blood material interaction in vitro tests gave good results: a low platelet adhesion and kallikrein generation and a high APTT value. Porous tubings (inner diameter 1.3 mm) were fabricated, by spinning from solution, for implantation in the abdominal aorta of rats. Stress-strain diagrams were comparable to those reported for natural blood vessels.
Original languageEnglish
Pages (from-to)393-399
JournalBiomaterials
Volume7
Issue number5
DOIs
Publication statusPublished - 1986

Keywords

  • Mechanical properties
  • IR-69597
  • Blood vessels
  • in vitro evaluation
  • Prostheses
  • polyethers
  • Poly(ethylene oxide)
  • Poly(propylene oxide)

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