The aim of this thesis was the development of stimulus responsive polymer brush structures as micropore switches for molecular screening. This was achieved by grafting pH responsive poly(methacrylic acid) (PMAA) brushes from nanoporous platforms that were then integrated in functional assays for membrane proteins. Several properties of the smart PMAA brush contributed to the functionality of such protein assays. Controlled transport of ions and molecules through nanopores, support of pore spanning artificial lipid bilayers and positioning of membrane proteins over the pores were achieved with the explored PMAA brush functionalized platforms.
|Award date||12 Dec 2013|
|Place of Publication||Enschede|
|Publication status||Published - 12 Dec 2013|
de Groot, G. W. (2013). Smart polymer brushes in nanopores: towards controlled molecular transport through pore-spanning biomembranes. Enschede: Ipskamp Printing. https://doi.org/10.3990/1.9789036507721