Smart polymer brushes in nanopores: towards controlled molecular transport through pore-spanning biomembranes

G.W. de Groot

doi:10.3990/1.9789036507721

Smart polymer brushes in nanopores: towards controlled molecular transport through pore-spanning biomembranes

G.W. de Groot

Research output: Thesis › PhD Thesis - Research UT, graduation UT

359 Downloads (Pure)

Abstract

The aim of this thesis was the development of stimulus responsive polymer brush structures as micropore switches for molecular screening. This was achieved by grafting pH responsive poly(methacrylic acid) (PMAA) brushes from nanoporous platforms that were then integrated in functional assays for membrane proteins. Several properties of the smart PMAA brush contributed to the functionality of such protein assays. Controlled transport of ions and molecules through nanopores, support of pore spanning artificial lipid bilayers and positioning of membrane proteins over the pores were achieved with the explored PMAA brush functionalized platforms.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Twente
Supervisors/Advisors	Vancso, G.J., Supervisor Santonicola, M., Advisor
Award date	12 Dec 2013
Place of Publication	Enschede
Publisher	Ipskamp Printing
Print ISBNs	978-90-365-0772-1
DOIs	https://doi.org/10.3990/1.9789036507721
Publication status	Published - 12 Dec 2013

Keywords

METIS-299294
IR-88056

Access to Document

10.3990/1.9789036507721

thesis_G_de_GrootFinal published version, 24.4 MB

Cite this

@phdthesis{0f8cf31780544c01ac0254a1b0139fde,

title = "Smart polymer brushes in nanopores: towards controlled molecular transport through pore-spanning biomembranes",

abstract = "The aim of this thesis was the development of stimulus responsive polymer brush structures as micropore switches for molecular screening. This was achieved by grafting pH responsive poly(methacrylic acid) (PMAA) brushes from nanoporous platforms that were then integrated in functional assays for membrane proteins. Several properties of the smart PMAA brush contributed to the functionality of such protein assays. Controlled transport of ions and molecules through nanopores, support of pore spanning artificial lipid bilayers and positioning of membrane proteins over the pores were achieved with the explored PMAA brush functionalized platforms.",

keywords = "METIS-299294, IR-88056",

author = "{de Groot}, G.W.",

year = "2013",

month = dec,

day = "12",

doi = "10.3990/1.9789036507721",

language = "English",

isbn = "978-90-365-0772-1",

publisher = "Ipskamp Printing",

address = "Netherlands",

type = "PhD Thesis - Research UT, graduation UT",

school = "University of Twente",

}

TY - THES

T1 - Smart polymer brushes in nanopores: towards controlled molecular transport through pore-spanning biomembranes

AU - de Groot, G.W.

PY - 2013/12/12

Y1 - 2013/12/12

N2 - The aim of this thesis was the development of stimulus responsive polymer brush structures as micropore switches for molecular screening. This was achieved by grafting pH responsive poly(methacrylic acid) (PMAA) brushes from nanoporous platforms that were then integrated in functional assays for membrane proteins. Several properties of the smart PMAA brush contributed to the functionality of such protein assays. Controlled transport of ions and molecules through nanopores, support of pore spanning artificial lipid bilayers and positioning of membrane proteins over the pores were achieved with the explored PMAA brush functionalized platforms.

AB - The aim of this thesis was the development of stimulus responsive polymer brush structures as micropore switches for molecular screening. This was achieved by grafting pH responsive poly(methacrylic acid) (PMAA) brushes from nanoporous platforms that were then integrated in functional assays for membrane proteins. Several properties of the smart PMAA brush contributed to the functionality of such protein assays. Controlled transport of ions and molecules through nanopores, support of pore spanning artificial lipid bilayers and positioning of membrane proteins over the pores were achieved with the explored PMAA brush functionalized platforms.

KW - METIS-299294

KW - IR-88056

U2 - 10.3990/1.9789036507721

DO - 10.3990/1.9789036507721

M3 - PhD Thesis - Research UT, graduation UT

SN - 978-90-365-0772-1

PB - Ipskamp Printing

CY - Enschede

ER -

Smart polymer brushes in nanopores: towards controlled molecular transport through pore-spanning biomembranes

Abstract

Keywords

Access to Document

Fingerprint

Cite this