Sonoporation with single bubbles in microfluidic systems

Séverine Le Gac; Ed Zwaan; Albert van den Berg; Claus-Dieter Ohl

doi:10.1063/1.2744319

Sonoporation with single bubbles in microfluidic systems

Séverine Le Gac^*, Ed Zwaan, Albert van den Berg, Claus-Dieter Ohl

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

1 Citation (Scopus)

5 Downloads (Pure)

Abstract

When bubbles oscillate close to cells in suspension they can cause viable or permanent poration of the cell membrane. This method named as sonoporation offers potentials for novel therapeutic applications in medicine i.e., cell killing or actively induced drug uptake. Until now, the details of bubble-to-cell interactions are not clarified especially due to a lack of experimental methods. Here we show that sonoporation of cells in suspension is made possible and can be studied in details when using a microfluidic system together with laser-induced cavitation bubbles.

Original language	English
Title of host publication	6th International Symposium on Therapeutic Ultrasound
Subtitle of host publication	30 August-2 September 2006, Oxford (United Kingdom)
Editors	Constantin-C. Coussios, Gail ter Haar
Publisher	American Institute of Physics
Pages	492-497
Number of pages	6
ISBN (Print)	978-0-7354-0419-9
DOIs	https://doi.org/10.1063/1.2744319
Publication status	Published - 2007
Event	6th International Symposium on Therapeutic Ultrasound, ISTU 2006 - Oxford, United Kingdom Duration: 30 Aug 2006 → 2 Sept 2006 Conference number: 6

Publication series

Name	AIP Conference Proceedings
Volume	911
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	6th International Symposium on Therapeutic Ultrasound, ISTU 2006
Abbreviated title	ISTU
Country/Territory	United Kingdom
City	Oxford
Period	30/08/06 → 2/09/06

Keywords

Cavitation
Lab-on-a-chip
Sonoporation
Suspension cells

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10.1063/1.2744319

Cite this

Le Gac, S., Zwaan, E., van den Berg, A., & Ohl, C.-D. (2007). Sonoporation with single bubbles in microfluidic systems. In C.-C. Coussios, & G. ter Haar (Eds.), 6th International Symposium on Therapeutic Ultrasound: 30 August-2 September 2006, Oxford (United Kingdom) (pp. 492-497). (AIP Conference Proceedings; Vol. 911). American Institute of Physics. https://doi.org/10.1063/1.2744319

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title = "Sonoporation with single bubbles in microfluidic systems",

abstract = "When bubbles oscillate close to cells in suspension they can cause viable or permanent poration of the cell membrane. This method named as sonoporation offers potentials for novel therapeutic applications in medicine i.e., cell killing or actively induced drug uptake. Until now, the details of bubble-to-cell interactions are not clarified especially due to a lack of experimental methods. Here we show that sonoporation of cells in suspension is made possible and can be studied in details when using a microfluidic system together with laser-induced cavitation bubbles.",

keywords = "Cavitation, Lab-on-a-chip, Sonoporation, Suspension cells",

author = "{Le Gac}, S{\'e}verine and Ed Zwaan and {van den Berg}, Albert and Claus-Dieter Ohl",

year = "2007",

doi = "10.1063/1.2744319",

language = "English",

isbn = "978-0-7354-0419-9",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics",

pages = "492--497",

editor = "Constantin-C. Coussios and {ter Haar}, Gail",

booktitle = "6th International Symposium on Therapeutic Ultrasound",

address = "United States",

note = "6th International Symposium on Therapeutic Ultrasound, ISTU 2006, ISTU ; Conference date: 30-08-2006 Through 02-09-2006",

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Le Gac, S, Zwaan, E, van den Berg, A & Ohl, C-D 2007, Sonoporation with single bubbles in microfluidic systems. in C-C Coussios & G ter Haar (eds), 6th International Symposium on Therapeutic Ultrasound: 30 August-2 September 2006, Oxford (United Kingdom). AIP Conference Proceedings, vol. 911, American Institute of Physics, pp. 492-497, 6th International Symposium on Therapeutic Ultrasound, ISTU 2006, Oxford, United Kingdom, 30/08/06. https://doi.org/10.1063/1.2744319

Sonoporation with single bubbles in microfluidic systems. / Le Gac, Séverine; Zwaan, Ed; van den Berg, Albert et al.
6th International Symposium on Therapeutic Ultrasound: 30 August-2 September 2006, Oxford (United Kingdom). ed. / Constantin-C. Coussios; Gail ter Haar. American Institute of Physics, 2007. p. 492-497 (AIP Conference Proceedings; Vol. 911).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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N2 - When bubbles oscillate close to cells in suspension they can cause viable or permanent poration of the cell membrane. This method named as sonoporation offers potentials for novel therapeutic applications in medicine i.e., cell killing or actively induced drug uptake. Until now, the details of bubble-to-cell interactions are not clarified especially due to a lack of experimental methods. Here we show that sonoporation of cells in suspension is made possible and can be studied in details when using a microfluidic system together with laser-induced cavitation bubbles.

AB - When bubbles oscillate close to cells in suspension they can cause viable or permanent poration of the cell membrane. This method named as sonoporation offers potentials for novel therapeutic applications in medicine i.e., cell killing or actively induced drug uptake. Until now, the details of bubble-to-cell interactions are not clarified especially due to a lack of experimental methods. Here we show that sonoporation of cells in suspension is made possible and can be studied in details when using a microfluidic system together with laser-induced cavitation bubbles.

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KW - Lab-on-a-chip

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Y2 - 30 August 2006 through 2 September 2006

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Sonoporation with single bubbles in microfluidic systems

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