Sonoporation with single bubbles in microfluidic systems

Séverine Le Gac*, Ed Zwaan, Albert van den Berg, Claus-Dieter Ohl

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

1 Citation (Scopus)
3 Downloads (Pure)


When bubbles oscillate close to cells in suspension they can cause viable or permanent poration of the cell membrane. This method named as sonoporation offers potentials for novel therapeutic applications in medicine i.e., cell killing or actively induced drug uptake. Until now, the details of bubble-to-cell interactions are not clarified especially due to a lack of experimental methods. Here we show that sonoporation of cells in suspension is made possible and can be studied in details when using a microfluidic system together with laser-induced cavitation bubbles.

Original languageEnglish
Title of host publication6th International Symposium on Therapeutic Ultrasound
Subtitle of host publication30 August-2 September 2006, Oxford (United Kingdom)
EditorsConstantin-C. Coussios, Gail ter Haar
PublisherAmerican Institute of Physics
Number of pages6
ISBN (Print)978-0-7354-0419-9
Publication statusPublished - 2007
Event6th International Symposium on Therapeutic Ultrasound, ISTU 2006 - Oxford, United Kingdom
Duration: 30 Aug 20062 Sept 2006
Conference number: 6

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


Conference6th International Symposium on Therapeutic Ultrasound, ISTU 2006
Abbreviated titleISTU
Country/TerritoryUnited Kingdom


  • Cavitation
  • Lab-on-a-chip
  • Sonoporation
  • Suspension cells


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