TY - JOUR
T1 - Space and frequency dependence of nanocapacitor array sensors response to microparticles in electrolyte
AU - Cossettini, Andrea
AU - Laborde, Cecilia
AU - Brandalise, Denis
AU - Widdershoven, Frans
AU - Lemay, Serge G.
AU - Selmi, Luca
N1 - Funding Information:
Manuscript received August 21, 2020; revised October 12, 2020; accepted October 14, 2020. Date of publication October 21, 2020; date of current version January 15, 2021. The work of Andrea Cossettini, Denis Brandalise, and Luca Selmi was supported by the Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR) FLAG-ERA CONVERGENCE Project via the Consorzio Nazionale Interuniversitario per la Nanoelettronica (IUNET) consortium. The work of Cecilia Laborde and Serge G. Lemay was supported by the European Research Council (ERC) under Project 278801. The associate editor coordinating the review of this article and approving it for publication was Prof. Tarikul Islam. (Corresponding author: Andrea Cossettini.) Andrea Cossettini was with the DPIA, University of Udine, 33100 Udine, Italy. He is now with the IIS, ETH Zürich, 8092 Zürich, Switzerland (e-mail: [email protected]).
Publisher Copyright:
© 2001-2012 IEEE.
PY - 2021/2/15
Y1 - 2021/2/15
N2 - We present new experimental evidence and extensive numerical simulations of a few distinct fingerprints generated by dielectric and conductive microparticles in electrolyte environment on the capacitance spectra of nanoelectrode array sensors. Finite element simulations in good agreement with measurements allow us to identify unambiguously the physical origin of these features, and to illustrate their dependence on the system's geometrical and physical properties. In particular, we show that conductive particles induce a response with complex space and frequency dependencies, caused by the formation of an AC electrical double layer at the particle surface, and its interaction with the working and counter electrodes in the array. Furthermore, we highlight features that could lead to false-negative detection events in sensing applications. The theoretical predictions are confirmed by experiments on a state of the art CMOS pixelated nanocapacitor biosensor platform.
AB - We present new experimental evidence and extensive numerical simulations of a few distinct fingerprints generated by dielectric and conductive microparticles in electrolyte environment on the capacitance spectra of nanoelectrode array sensors. Finite element simulations in good agreement with measurements allow us to identify unambiguously the physical origin of these features, and to illustrate their dependence on the system's geometrical and physical properties. In particular, we show that conductive particles induce a response with complex space and frequency dependencies, caused by the formation of an AC electrical double layer at the particle surface, and its interaction with the working and counter electrodes in the array. Furthermore, we highlight features that could lead to false-negative detection events in sensing applications. The theoretical predictions are confirmed by experiments on a state of the art CMOS pixelated nanocapacitor biosensor platform.
KW - 2022 OA procedure
KW - electrical double layer
KW - Nanocapacitor arrays
KW - capacitance spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=85099792072&partnerID=8YFLogxK
U2 - 10.1109/JSEN.2020.3032712
DO - 10.1109/JSEN.2020.3032712
M3 - Article
AN - SCOPUS:85099792072
SN - 1530-437X
VL - 21
SP - 4696
EP - 4704
JO - IEEE sensors journal
JF - IEEE sensors journal
IS - 4
M1 - 9234466
ER -