Sparse pallidal connections shape synchrony in a network model of the basal ganglia

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
1 Downloads (Pure)

Abstract

Neural synchrony in the basal ganglia, especially in the beta frequency band (13-30 Hz), is a hallmark of Parkinson's disease and considered as antikinetic. In contrast, the healthy basal ganglia show low levels of synchrony. It is currently unknown where synchrony and oscillations arise in the parkinsonian brain and how they are transmitted through the basal ganglia, as well as what makes them dependent on dopamine. The external part of the globus pallidus has recently been identified as a hub nucleus in the basal ganglia, possessing intrinsic inhibitory connections and possibly also gap junctions. In this study, we show that in a conductance-based network model of the basal ganglia, the combination of sparse, high-conductance inhibitory synapses and sparse, low-conductance gap junctions in the external part of the globus pallidus could effectively desynchronize the whole network. However, when gap junction coupling became strong enough, the effect was impeded and activity synchronized. In particular, sustained periods of beta coherence occurred between some neuron pairs. As gap junctions can change their conductance with the dopamine level, we suggest pallidal gap junction coupling as a mechanism contributing to the development of beta synchrony in the parkinsonian basal ganglia. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
Original languageEnglish
Pages (from-to)1000-1012
Number of pages13
JournalEuropean journal of neuroscience
Volume45
Issue number8
DOIs
Publication statusPublished - 1 Apr 2017

Fingerprint

Basal Ganglia
Gap Junctions
Globus Pallidus
Dopamine
Synapses
Parkinson Disease
Neurons
Brain

Keywords

  • beta oscillations
  • dopamine
  • gap junctions
  • globus pallidus
  • inhibition

Cite this

@article{d838e75cb4b3438bb3bfcdbdfb6bbfda,
title = "Sparse pallidal connections shape synchrony in a network model of the basal ganglia",
abstract = "Neural synchrony in the basal ganglia, especially in the beta frequency band (13-30 Hz), is a hallmark of Parkinson's disease and considered as antikinetic. In contrast, the healthy basal ganglia show low levels of synchrony. It is currently unknown where synchrony and oscillations arise in the parkinsonian brain and how they are transmitted through the basal ganglia, as well as what makes them dependent on dopamine. The external part of the globus pallidus has recently been identified as a hub nucleus in the basal ganglia, possessing intrinsic inhibitory connections and possibly also gap junctions. In this study, we show that in a conductance-based network model of the basal ganglia, the combination of sparse, high-conductance inhibitory synapses and sparse, low-conductance gap junctions in the external part of the globus pallidus could effectively desynchronize the whole network. However, when gap junction coupling became strong enough, the effect was impeded and activity synchronized. In particular, sustained periods of beta coherence occurred between some neuron pairs. As gap junctions can change their conductance with the dopamine level, we suggest pallidal gap junction coupling as a mechanism contributing to the development of beta synchrony in the parkinsonian basal ganglia. (PsycINFO Database Record (c) 2017 APA, all rights reserved)",
keywords = "beta oscillations, dopamine, gap junctions, globus pallidus, inhibition",
author = "Schwab, {Bettina C.} and {van Wezel}, {Richard J.A.} and {van Gils}, {Stephanus A.}",
year = "2017",
month = "4",
day = "1",
doi = "10.1111/ejn.13324",
language = "English",
volume = "45",
pages = "1000--1012",
journal = "European journal of neuroscience",
issn = "0953-816X",
publisher = "Wiley-Blackwell",
number = "8",

}

Sparse pallidal connections shape synchrony in a network model of the basal ganglia. / Schwab, Bettina C.; van Wezel, Richard J.A.; van Gils, Stephanus A.

In: European journal of neuroscience, Vol. 45, No. 8, 01.04.2017, p. 1000-1012.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Sparse pallidal connections shape synchrony in a network model of the basal ganglia

AU - Schwab, Bettina C.

AU - van Wezel, Richard J.A.

AU - van Gils, Stephanus A.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Neural synchrony in the basal ganglia, especially in the beta frequency band (13-30 Hz), is a hallmark of Parkinson's disease and considered as antikinetic. In contrast, the healthy basal ganglia show low levels of synchrony. It is currently unknown where synchrony and oscillations arise in the parkinsonian brain and how they are transmitted through the basal ganglia, as well as what makes them dependent on dopamine. The external part of the globus pallidus has recently been identified as a hub nucleus in the basal ganglia, possessing intrinsic inhibitory connections and possibly also gap junctions. In this study, we show that in a conductance-based network model of the basal ganglia, the combination of sparse, high-conductance inhibitory synapses and sparse, low-conductance gap junctions in the external part of the globus pallidus could effectively desynchronize the whole network. However, when gap junction coupling became strong enough, the effect was impeded and activity synchronized. In particular, sustained periods of beta coherence occurred between some neuron pairs. As gap junctions can change their conductance with the dopamine level, we suggest pallidal gap junction coupling as a mechanism contributing to the development of beta synchrony in the parkinsonian basal ganglia. (PsycINFO Database Record (c) 2017 APA, all rights reserved)

AB - Neural synchrony in the basal ganglia, especially in the beta frequency band (13-30 Hz), is a hallmark of Parkinson's disease and considered as antikinetic. In contrast, the healthy basal ganglia show low levels of synchrony. It is currently unknown where synchrony and oscillations arise in the parkinsonian brain and how they are transmitted through the basal ganglia, as well as what makes them dependent on dopamine. The external part of the globus pallidus has recently been identified as a hub nucleus in the basal ganglia, possessing intrinsic inhibitory connections and possibly also gap junctions. In this study, we show that in a conductance-based network model of the basal ganglia, the combination of sparse, high-conductance inhibitory synapses and sparse, low-conductance gap junctions in the external part of the globus pallidus could effectively desynchronize the whole network. However, when gap junction coupling became strong enough, the effect was impeded and activity synchronized. In particular, sustained periods of beta coherence occurred between some neuron pairs. As gap junctions can change their conductance with the dopamine level, we suggest pallidal gap junction coupling as a mechanism contributing to the development of beta synchrony in the parkinsonian basal ganglia. (PsycINFO Database Record (c) 2017 APA, all rights reserved)

KW - beta oscillations

KW - dopamine

KW - gap junctions

KW - globus pallidus

KW - inhibition

U2 - 10.1111/ejn.13324

DO - 10.1111/ejn.13324

M3 - Article

VL - 45

SP - 1000

EP - 1012

JO - European journal of neuroscience

JF - European journal of neuroscience

SN - 0953-816X

IS - 8

ER -