Sparse pallidal connections shape synchrony in a network model of the basal ganglia

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    Abstract

    Neural synchrony in the basal ganglia, especially in the beta frequency band (13-30 Hz), is a hallmark of Parkinson's disease and considered as antikinetic. In contrast, the healthy basal ganglia show low levels of synchrony. It is currently unknown where synchrony and oscillations arise in the parkinsonian brain and how they are transmitted through the basal ganglia, as well as what makes them dependent on dopamine. The external part of the globus pallidus has recently been identified as a hub nucleus in the basal ganglia, possessing intrinsic inhibitory connections and possibly also gap junctions. In this study, we show that in a conductance-based network model of the basal ganglia, the combination of sparse, high-conductance inhibitory synapses and sparse, low-conductance gap junctions in the external part of the globus pallidus could effectively desynchronize the whole network. However, when gap junction coupling became strong enough, the effect was impeded and activity synchronized. In particular, sustained periods of beta coherence occurred between some neuron pairs. As gap junctions can change their conductance with the dopamine level, we suggest pallidal gap junction coupling as a mechanism contributing to the development of beta synchrony in the parkinsonian basal ganglia. (PsycINFO Database Record (c) 2017 APA, all rights reserved)
    Original languageEnglish
    Pages (from-to)1000-1012
    Number of pages13
    JournalEuropean journal of neuroscience
    Volume45
    Issue number8
    DOIs
    Publication statusPublished - 1 Apr 2017

    Fingerprint

    Basal Ganglia
    Gap Junctions
    Globus Pallidus
    Dopamine
    Synapses
    Parkinson Disease
    Neurons
    Brain

    Keywords

    • beta oscillations
    • dopamine
    • gap junctions
    • globus pallidus
    • inhibition

    Cite this

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    title = "Sparse pallidal connections shape synchrony in a network model of the basal ganglia",
    abstract = "Neural synchrony in the basal ganglia, especially in the beta frequency band (13-30 Hz), is a hallmark of Parkinson's disease and considered as antikinetic. In contrast, the healthy basal ganglia show low levels of synchrony. It is currently unknown where synchrony and oscillations arise in the parkinsonian brain and how they are transmitted through the basal ganglia, as well as what makes them dependent on dopamine. The external part of the globus pallidus has recently been identified as a hub nucleus in the basal ganglia, possessing intrinsic inhibitory connections and possibly also gap junctions. In this study, we show that in a conductance-based network model of the basal ganglia, the combination of sparse, high-conductance inhibitory synapses and sparse, low-conductance gap junctions in the external part of the globus pallidus could effectively desynchronize the whole network. However, when gap junction coupling became strong enough, the effect was impeded and activity synchronized. In particular, sustained periods of beta coherence occurred between some neuron pairs. As gap junctions can change their conductance with the dopamine level, we suggest pallidal gap junction coupling as a mechanism contributing to the development of beta synchrony in the parkinsonian basal ganglia. (PsycINFO Database Record (c) 2017 APA, all rights reserved)",
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    Sparse pallidal connections shape synchrony in a network model of the basal ganglia. / Schwab, Bettina C.; van Wezel, Richard J.A.; van Gils, Stephanus A.

    In: European journal of neuroscience, Vol. 45, No. 8, 01.04.2017, p. 1000-1012.

    Research output: Contribution to journalArticleAcademicpeer-review

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    AB - Neural synchrony in the basal ganglia, especially in the beta frequency band (13-30 Hz), is a hallmark of Parkinson's disease and considered as antikinetic. In contrast, the healthy basal ganglia show low levels of synchrony. It is currently unknown where synchrony and oscillations arise in the parkinsonian brain and how they are transmitted through the basal ganglia, as well as what makes them dependent on dopamine. The external part of the globus pallidus has recently been identified as a hub nucleus in the basal ganglia, possessing intrinsic inhibitory connections and possibly also gap junctions. In this study, we show that in a conductance-based network model of the basal ganglia, the combination of sparse, high-conductance inhibitory synapses and sparse, low-conductance gap junctions in the external part of the globus pallidus could effectively desynchronize the whole network. However, when gap junction coupling became strong enough, the effect was impeded and activity synchronized. In particular, sustained periods of beta coherence occurred between some neuron pairs. As gap junctions can change their conductance with the dopamine level, we suggest pallidal gap junction coupling as a mechanism contributing to the development of beta synchrony in the parkinsonian basal ganglia. (PsycINFO Database Record (c) 2017 APA, all rights reserved)

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