Spatial localization of sources in the rat subthalamic motor region using an inverse current source density method

Kees J. van Dijk, Marcus L.F. Janssen, Daphne G.M Zwartjes, Yasin Temel, Veerle Visser-Vandewalle, Peter H. Veltink, Abdelhamid Benazzouz, Tjitske Heida

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Abstract

Objective: In this study we introduce the use of the current source density (CSD) method as a way to visualize the spatial organization of evoked responses in the rat subthalamic nucleus (STN) at fixed time stamps resulting from motor cortex stimulation. This method offers opportunities to visualize neuronal input and study the relation between the synaptic input and the neural output of neural populations.
Approach: Motor cortex evoked local field potentials and unit activity were measured in the subthalamic region, with a 3D measurement grid consisting of 320 measurement points and high spatial resolution. This allowed us to visualize the evoked synaptic input by estimating the current source density (CSD) from the measured local field potentials, using the inverse CSD method. At the same time, the neuronal output of the cells within the grid is assessed by calculating post stimulus time histograms.
Main results: The CSD method resulted in clear and distinguishable sources and sinks of the neuronal input activity in the STN after motor cortex stimulation. We showed that the center of the synaptic input of the STN from the motor cortex is located dorsal to the input from globus pallidus.
Significance: For the first time we have performed CSD analysis on motor cortex stimulation evoked LFP responses in the rat STN as a proof of principle. Our results suggest that the CSD method can be used to gain new insights into the spatial extent of synaptic pathways in brain structures.
Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalFrontiers in neural circuits
Volume10
DOIs
Publication statusPublished - 3 Nov 2016

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Motor Cortex
Subthalamic Nucleus
Globus Pallidus
Brain
Population

Keywords

  • BSS-Electrical Neurostimulation
  • Inverse current source density analysis
  • Local field potentials
  • Rodents
  • Action potentials
  • Cortical stimulation
  • Subthalamic nucleus

Cite this

van Dijk, Kees J. ; Janssen, Marcus L.F. ; Zwartjes, Daphne G.M ; Temel, Yasin ; Visser-Vandewalle, Veerle ; Veltink, Peter H. ; Benazzouz, Abdelhamid ; Heida, Tjitske. / Spatial localization of sources in the rat subthalamic motor region using an inverse current source density method. In: Frontiers in neural circuits. 2016 ; Vol. 10. pp. 1-11.
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Spatial localization of sources in the rat subthalamic motor region using an inverse current source density method. / van Dijk, Kees J.; Janssen, Marcus L.F.; Zwartjes, Daphne G.M; Temel, Yasin; Visser-Vandewalle, Veerle; Veltink, Peter H.; Benazzouz, Abdelhamid; Heida, Tjitske.

In: Frontiers in neural circuits, Vol. 10, 03.11.2016, p. 1-11.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Spatial localization of sources in the rat subthalamic motor region using an inverse current source density method

AU - van Dijk, Kees J.

AU - Janssen, Marcus L.F.

AU - Zwartjes, Daphne G.M

AU - Temel, Yasin

AU - Visser-Vandewalle, Veerle

AU - Veltink, Peter H.

AU - Benazzouz, Abdelhamid

AU - Heida, Tjitske

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N2 - Objective: In this study we introduce the use of the current source density (CSD) method as a way to visualize the spatial organization of evoked responses in the rat subthalamic nucleus (STN) at fixed time stamps resulting from motor cortex stimulation. This method offers opportunities to visualize neuronal input and study the relation between the synaptic input and the neural output of neural populations.Approach: Motor cortex evoked local field potentials and unit activity were measured in the subthalamic region, with a 3D measurement grid consisting of 320 measurement points and high spatial resolution. This allowed us to visualize the evoked synaptic input by estimating the current source density (CSD) from the measured local field potentials, using the inverse CSD method. At the same time, the neuronal output of the cells within the grid is assessed by calculating post stimulus time histograms.Main results: The CSD method resulted in clear and distinguishable sources and sinks of the neuronal input activity in the STN after motor cortex stimulation. We showed that the center of the synaptic input of the STN from the motor cortex is located dorsal to the input from globus pallidus.Significance: For the first time we have performed CSD analysis on motor cortex stimulation evoked LFP responses in the rat STN as a proof of principle. Our results suggest that the CSD method can be used to gain new insights into the spatial extent of synaptic pathways in brain structures.

AB - Objective: In this study we introduce the use of the current source density (CSD) method as a way to visualize the spatial organization of evoked responses in the rat subthalamic nucleus (STN) at fixed time stamps resulting from motor cortex stimulation. This method offers opportunities to visualize neuronal input and study the relation between the synaptic input and the neural output of neural populations.Approach: Motor cortex evoked local field potentials and unit activity were measured in the subthalamic region, with a 3D measurement grid consisting of 320 measurement points and high spatial resolution. This allowed us to visualize the evoked synaptic input by estimating the current source density (CSD) from the measured local field potentials, using the inverse CSD method. At the same time, the neuronal output of the cells within the grid is assessed by calculating post stimulus time histograms.Main results: The CSD method resulted in clear and distinguishable sources and sinks of the neuronal input activity in the STN after motor cortex stimulation. We showed that the center of the synaptic input of the STN from the motor cortex is located dorsal to the input from globus pallidus.Significance: For the first time we have performed CSD analysis on motor cortex stimulation evoked LFP responses in the rat STN as a proof of principle. Our results suggest that the CSD method can be used to gain new insights into the spatial extent of synaptic pathways in brain structures.

KW - BSS-Electrical Neurostimulation

KW - Inverse current source density analysis

KW - Local field potentials

KW - Rodents

KW - Action potentials

KW - Cortical stimulation

KW - Subthalamic nucleus

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DO - 10.3389/fncir.2016.00087

M3 - Article

VL - 10

SP - 1

EP - 11

JO - Frontiers in neural circuits

JF - Frontiers in neural circuits

SN - 1662-5110

ER -