Spatial resolution of the inveon small-animal PET scanner for the entire field of view

J.A. Disselhorst, O.C. Boerman, W.J.G. Oyen, Cornelis H. Slump, E.P. Visser

    Research output: Contribution to journalArticleAcademicpeer-review

    4 Citations (Scopus)

    Abstract

    In high throughput small-animal positron emission tomography (PET) studies, it can be advantageous to scan more than one animal at the same time. To optimally position these animals in the scanner, both sensitivity and spatial resolution have to be known across the entire field of view (FOV). The Siemens Inveon small-animal PET scanner has been characterized according to NEMA NU 4-2008 standards, but the spatial resolution has only been determined in a small portion of the FOV and only for filtered backprojection (FBP). In this study, the spatial resolution in the entire FOV was determined for the Inveon using FBP, ordered subset expectation maximization in 2 dimensions (OSEM2D) and maximum a posteriori (MAP) reconstructions. OSEM2D produced the best spatial resolution in the axial center of the FOV, but MAP outperformed the two other reconstruction algorithms in terms of uniformity of the resolution.
    Original languageUndefined
    Pages (from-to)245-248
    Number of pages4
    JournalNuclear instruments & methods in physics research. Section A : Accelerators, spectrometers, detectors and associated equipment
    Volume615
    Issue number2
    DOIs
    Publication statusPublished - 10 Feb 2010

    Keywords

    • METIS-275959
    • Inveon
    • Positron emission tomography
    • EWI-19851
    • Spatial resolution
    • IR-76488
    • Small animal
    • Maximum a posteriori reconstruction

    Cite this

    @article{514b6187a1664b51b6dcecb0550940f6,
    title = "Spatial resolution of the inveon small-animal PET scanner for the entire field of view",
    abstract = "In high throughput small-animal positron emission tomography (PET) studies, it can be advantageous to scan more than one animal at the same time. To optimally position these animals in the scanner, both sensitivity and spatial resolution have to be known across the entire field of view (FOV). The Siemens Inveon small-animal PET scanner has been characterized according to NEMA NU 4-2008 standards, but the spatial resolution has only been determined in a small portion of the FOV and only for filtered backprojection (FBP). In this study, the spatial resolution in the entire FOV was determined for the Inveon using FBP, ordered subset expectation maximization in 2 dimensions (OSEM2D) and maximum a posteriori (MAP) reconstructions. OSEM2D produced the best spatial resolution in the axial center of the FOV, but MAP outperformed the two other reconstruction algorithms in terms of uniformity of the resolution.",
    keywords = "METIS-275959, Inveon, Positron emission tomography, EWI-19851, Spatial resolution, IR-76488, Small animal, Maximum a posteriori reconstruction",
    author = "J.A. Disselhorst and O.C. Boerman and W.J.G. Oyen and Slump, {Cornelis H.} and E.P. Visser",
    note = "10.1016/j.nima.2010.02.073",
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    doi = "10.1016/j.nima.2010.02.073",
    language = "Undefined",
    volume = "615",
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    journal = "Nuclear instruments & methods in physics research. Section A : Accelerators, spectrometers, detectors and associated equipment",
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    }

    Spatial resolution of the inveon small-animal PET scanner for the entire field of view. / Disselhorst, J.A.; Boerman, O.C.; Oyen, W.J.G.; Slump, Cornelis H.; Visser, E.P.

    In: Nuclear instruments & methods in physics research. Section A : Accelerators, spectrometers, detectors and associated equipment, Vol. 615, No. 2, 10.02.2010, p. 245-248.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Spatial resolution of the inveon small-animal PET scanner for the entire field of view

    AU - Disselhorst, J.A.

    AU - Boerman, O.C.

    AU - Oyen, W.J.G.

    AU - Slump, Cornelis H.

    AU - Visser, E.P.

    N1 - 10.1016/j.nima.2010.02.073

    PY - 2010/2/10

    Y1 - 2010/2/10

    N2 - In high throughput small-animal positron emission tomography (PET) studies, it can be advantageous to scan more than one animal at the same time. To optimally position these animals in the scanner, both sensitivity and spatial resolution have to be known across the entire field of view (FOV). The Siemens Inveon small-animal PET scanner has been characterized according to NEMA NU 4-2008 standards, but the spatial resolution has only been determined in a small portion of the FOV and only for filtered backprojection (FBP). In this study, the spatial resolution in the entire FOV was determined for the Inveon using FBP, ordered subset expectation maximization in 2 dimensions (OSEM2D) and maximum a posteriori (MAP) reconstructions. OSEM2D produced the best spatial resolution in the axial center of the FOV, but MAP outperformed the two other reconstruction algorithms in terms of uniformity of the resolution.

    AB - In high throughput small-animal positron emission tomography (PET) studies, it can be advantageous to scan more than one animal at the same time. To optimally position these animals in the scanner, both sensitivity and spatial resolution have to be known across the entire field of view (FOV). The Siemens Inveon small-animal PET scanner has been characterized according to NEMA NU 4-2008 standards, but the spatial resolution has only been determined in a small portion of the FOV and only for filtered backprojection (FBP). In this study, the spatial resolution in the entire FOV was determined for the Inveon using FBP, ordered subset expectation maximization in 2 dimensions (OSEM2D) and maximum a posteriori (MAP) reconstructions. OSEM2D produced the best spatial resolution in the axial center of the FOV, but MAP outperformed the two other reconstruction algorithms in terms of uniformity of the resolution.

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    KW - Positron emission tomography

    KW - EWI-19851

    KW - Spatial resolution

    KW - IR-76488

    KW - Small animal

    KW - Maximum a posteriori reconstruction

    U2 - 10.1016/j.nima.2010.02.073

    DO - 10.1016/j.nima.2010.02.073

    M3 - Article

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