Spatial resolution of the inveon small-animal PET scanner for the entire field of view

J.A. Disselhorst; O.C. Boerman; W.J.G. Oyen; Cornelis H. Slump; E.P. Visser

doi:10.1016/j.nima.2010.02.073

Spatial resolution of the inveon small-animal PET scanner for the entire field of view

J.A. Disselhorst, O.C. Boerman, W.J.G. Oyen, Cornelis H. Slump, E.P. Visser

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

In high throughput small-animal positron emission tomography (PET) studies, it can be advantageous to scan more than one animal at the same time. To optimally position these animals in the scanner, both sensitivity and spatial resolution have to be known across the entire field of view (FOV). The Siemens Inveon small-animal PET scanner has been characterized according to NEMA NU 4-2008 standards, but the spatial resolution has only been determined in a small portion of the FOV and only for filtered backprojection (FBP). In this study, the spatial resolution in the entire FOV was determined for the Inveon using FBP, ordered subset expectation maximization in 2 dimensions (OSEM2D) and maximum a posteriori (MAP) reconstructions. OSEM2D produced the best spatial resolution in the axial center of the FOV, but MAP outperformed the two other reconstruction algorithms in terms of uniformity of the resolution.

Original language	Undefined
Pages (from-to)	245-248
Number of pages	4
Journal	Nuclear instruments & methods in physics research. Section A : Accelerators, spectrometers, detectors and associated equipment
Volume	615
Issue number	2
DOIs	https://doi.org/10.1016/j.nima.2010.02.073
Publication status	Published - 10 Feb 2010

Keywords

METIS-275959
Inveon
Positron emission tomography
EWI-19851
Spatial resolution
IR-76488
Small animal
Maximum a posteriori reconstruction

Access to Document

10.1016/j.nima.2010.02.073

http://eprints.eemcs.utwente.nl/secure2/19851/01/2010_disselhorst_spatial.pdf

Cite this

Disselhorst, J. A., Boerman, O. C., Oyen, W. J. G., Slump, C. H., & Visser, E. P. (2010). Spatial resolution of the inveon small-animal PET scanner for the entire field of view. Nuclear instruments & methods in physics research. Section A : Accelerators, spectrometers, detectors and associated equipment, 615(2), 245-248. https://doi.org/10.1016/j.nima.2010.02.073

@article{514b6187a1664b51b6dcecb0550940f6,

title = "Spatial resolution of the inveon small-animal PET scanner for the entire field of view",

abstract = "In high throughput small-animal positron emission tomography (PET) studies, it can be advantageous to scan more than one animal at the same time. To optimally position these animals in the scanner, both sensitivity and spatial resolution have to be known across the entire field of view (FOV). The Siemens Inveon small-animal PET scanner has been characterized according to NEMA NU 4-2008 standards, but the spatial resolution has only been determined in a small portion of the FOV and only for filtered backprojection (FBP). In this study, the spatial resolution in the entire FOV was determined for the Inveon using FBP, ordered subset expectation maximization in 2 dimensions (OSEM2D) and maximum a posteriori (MAP) reconstructions. OSEM2D produced the best spatial resolution in the axial center of the FOV, but MAP outperformed the two other reconstruction algorithms in terms of uniformity of the resolution.",

keywords = "METIS-275959, Inveon, Positron emission tomography, EWI-19851, Spatial resolution, IR-76488, Small animal, Maximum a posteriori reconstruction",

author = "J.A. Disselhorst and O.C. Boerman and W.J.G. Oyen and Slump, {Cornelis H.} and E.P. Visser",

note = "10.1016/j.nima.2010.02.073",

year = "2010",

month = "2",

day = "10",

doi = "10.1016/j.nima.2010.02.073",

language = "Undefined",

volume = "615",

pages = "245--248",

journal = "Nuclear instruments & methods in physics research. Section A : Accelerators, spectrometers, detectors and associated equipment",

issn = "0168-9002",

publisher = "Elsevier",

number = "2",

}

Spatial resolution of the inveon small-animal PET scanner for the entire field of view. / Disselhorst, J.A.; Boerman, O.C.; Oyen, W.J.G.; Slump, Cornelis H.; Visser, E.P.

In: Nuclear instruments & methods in physics research. Section A : Accelerators, spectrometers, detectors and associated equipment, Vol. 615, No. 2, 10.02.2010, p. 245-248.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Spatial resolution of the inveon small-animal PET scanner for the entire field of view

AU - Disselhorst, J.A.

AU - Boerman, O.C.

AU - Oyen, W.J.G.

AU - Slump, Cornelis H.

AU - Visser, E.P.

N1 - 10.1016/j.nima.2010.02.073

PY - 2010/2/10

Y1 - 2010/2/10

N2 - In high throughput small-animal positron emission tomography (PET) studies, it can be advantageous to scan more than one animal at the same time. To optimally position these animals in the scanner, both sensitivity and spatial resolution have to be known across the entire field of view (FOV). The Siemens Inveon small-animal PET scanner has been characterized according to NEMA NU 4-2008 standards, but the spatial resolution has only been determined in a small portion of the FOV and only for filtered backprojection (FBP). In this study, the spatial resolution in the entire FOV was determined for the Inveon using FBP, ordered subset expectation maximization in 2 dimensions (OSEM2D) and maximum a posteriori (MAP) reconstructions. OSEM2D produced the best spatial resolution in the axial center of the FOV, but MAP outperformed the two other reconstruction algorithms in terms of uniformity of the resolution.

AB - In high throughput small-animal positron emission tomography (PET) studies, it can be advantageous to scan more than one animal at the same time. To optimally position these animals in the scanner, both sensitivity and spatial resolution have to be known across the entire field of view (FOV). The Siemens Inveon small-animal PET scanner has been characterized according to NEMA NU 4-2008 standards, but the spatial resolution has only been determined in a small portion of the FOV and only for filtered backprojection (FBP). In this study, the spatial resolution in the entire FOV was determined for the Inveon using FBP, ordered subset expectation maximization in 2 dimensions (OSEM2D) and maximum a posteriori (MAP) reconstructions. OSEM2D produced the best spatial resolution in the axial center of the FOV, but MAP outperformed the two other reconstruction algorithms in terms of uniformity of the resolution.

KW - METIS-275959

KW - Inveon

KW - Positron emission tomography

KW - EWI-19851

KW - Spatial resolution

KW - IR-76488

KW - Small animal

KW - Maximum a posteriori reconstruction

U2 - 10.1016/j.nima.2010.02.073

DO - 10.1016/j.nima.2010.02.073

M3 - Article

VL - 615

SP - 245

EP - 248

JO - Nuclear instruments & methods in physics research. Section A : Accelerators, spectrometers, detectors and associated equipment

JF - Nuclear instruments & methods in physics research. Section A : Accelerators, spectrometers, detectors and associated equipment

SN - 0168-9002

IS - 2

ER -