TY - JOUR
T1 - Spatially and temporally controlled hydrogels for tissue engineering
AU - J., Leijten
AU - Seo, Jungmok
AU - Yue, Kan
AU - Trujillo-de Santiago, Grissel
AU - Tamayol, Ali
AU - Ruiz-Esparza, Guillermo U.
AU - Ryon Shin, Su
AU - Sharifi, Roholah
AU - Noshadi, Iman
AU - Moises Alvarez, Mario
AU - Shrike Zhang, Yu
AU - Khademhosseini, Ali
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Recent years have seen tremendous advances in the field of hydrogel-based biomaterials. One of the most prominent revolutions in this field has been the integration of elements or techniques that enable spatial and temporal control over hydrogels’ properties and functions. Here, we critically review the emerging progress of spatiotemporal control over biomaterial properties towards the development of functional engineered tissue constructs. Specifically, we will highlight the main advances in the spatial control of biomaterials, such as surface modification, microfabrication, photo-patterning, and bioprinting, as well as advances in the temporal control of biomaterials, such as controlled release of molecules, photocleaving of proteins, and controlled hydrogel degradation. We believe that the development and integration of these techniques will drive the evolution of next-generation engineered tissues.
AB - Recent years have seen tremendous advances in the field of hydrogel-based biomaterials. One of the most prominent revolutions in this field has been the integration of elements or techniques that enable spatial and temporal control over hydrogels’ properties and functions. Here, we critically review the emerging progress of spatiotemporal control over biomaterial properties towards the development of functional engineered tissue constructs. Specifically, we will highlight the main advances in the spatial control of biomaterials, such as surface modification, microfabrication, photo-patterning, and bioprinting, as well as advances in the temporal control of biomaterials, such as controlled release of molecules, photocleaving of proteins, and controlled hydrogel degradation. We believe that the development and integration of these techniques will drive the evolution of next-generation engineered tissues.
KW - 22/4 OA procedure
U2 - 10.1016/j.mser.2017.07.001
DO - 10.1016/j.mser.2017.07.001
M3 - Article
SN - 0927-796X
VL - 119
SP - 1
EP - 35
JO - Materials Science and Engineering R: Reports
JF - Materials Science and Engineering R: Reports
ER -
