Spatially confined quantification of bilirubin concentrations by spectroscopic visible-light optical coherence tomography

Colin Veenstra (Corresponding Author), Wilma Petersen, Ivo M. Vellekoop, Wiendelt Steenbergen, Nienke Bosschaart

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
47 Downloads (Pure)

Abstract

Spatially confined measurements of bilirubin in tissue can be of great value for noninvasive bilirubin estimations during neonatal jaundice, as well as our understanding of the physiology behind bilirubin extravasation. This work shows the potential of spectroscopic visible-light optical coherence tomography (sOCT) for this purpose. At the bilirubin absorption peak around 460 nm, sOCT suffers from a strong signal decay with depth, which we overcome by optimizing our system sensitivity through a combination of zero-delay acquisition and focus tracking. In a phantom study, we demonstrate the quantification of bilirubin concentrations between 0 and 650 µM with only a 10% difference to the expected value, thereby covering the entire clinical pathophysiological range.

Original languageEnglish
Article number327320
Pages (from-to)3581-3589
Number of pages9
JournalBiomedical optics express
Volume9
Issue number8
DOIs
Publication statusPublished - 1 Aug 2018

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