Specific RNA dinucleotide cleavage by a synthetic calix[4]arene-based trinuclear metallo(II)-phosphodiesterase

Research output: Contribution to journalArticleAcademicpeer-review

105 Citations (Scopus)

Abstract

Large rate enhancements and considerable nucleobase specificity in the catalytic transesterification of RNA dinucleotides are observed with the calix[4]arene enzyme mimic 1-Zn3 (the computer-generated model of the complex with GpG is shown). The higher activity toward GpG over ApA (factor of 160) originates from favorable substrate binding and cooperative catalytic action of all three ZnII ions. The heterotrinuclear metallo-phosphoesterase mimic 1-Zn2Cu is even more active.
Original languageUndefined
Pages (from-to)3189-3192
JournalAngewandte Chemie (international edition)
Volume38
Issue number38
DOIs
Publication statusPublished - 1999

Keywords

  • METIS-106257
  • IR-11627

Cite this

@article{aab2c09a9eca452d95cba4fc37d3ae64,
title = "Specific RNA dinucleotide cleavage by a synthetic calix[4]arene-based trinuclear metallo(II)-phosphodiesterase",
abstract = "Large rate enhancements and considerable nucleobase specificity in the catalytic transesterification of RNA dinucleotides are observed with the calix[4]arene enzyme mimic 1-Zn3 (the computer-generated model of the complex with GpG is shown). The higher activity toward GpG over ApA (factor of 160) originates from favorable substrate binding and cooperative catalytic action of all three ZnII ions. The heterotrinuclear metallo-phosphoesterase mimic 1-Zn2Cu is even more active.",
keywords = "METIS-106257, IR-11627",
author = "P. Molenveld and Engbersen, {Johannes F.J.} and David Reinhoudt",
year = "1999",
doi = "10.1002/(SICI)1521-3773(19991102)38:21<3189::AID-ANIE3189>3.0.CO;2-X",
language = "Undefined",
volume = "38",
pages = "3189--3192",
journal = "Angewandte Chemie (international edition)",
issn = "1433-7851",
publisher = "Wiley",
number = "38",

}

Specific RNA dinucleotide cleavage by a synthetic calix[4]arene-based trinuclear metallo(II)-phosphodiesterase. / Molenveld, P.; Engbersen, Johannes F.J.; Reinhoudt, David.

In: Angewandte Chemie (international edition), Vol. 38, No. 38, 1999, p. 3189-3192.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Specific RNA dinucleotide cleavage by a synthetic calix[4]arene-based trinuclear metallo(II)-phosphodiesterase

AU - Molenveld, P.

AU - Engbersen, Johannes F.J.

AU - Reinhoudt, David

PY - 1999

Y1 - 1999

N2 - Large rate enhancements and considerable nucleobase specificity in the catalytic transesterification of RNA dinucleotides are observed with the calix[4]arene enzyme mimic 1-Zn3 (the computer-generated model of the complex with GpG is shown). The higher activity toward GpG over ApA (factor of 160) originates from favorable substrate binding and cooperative catalytic action of all three ZnII ions. The heterotrinuclear metallo-phosphoesterase mimic 1-Zn2Cu is even more active.

AB - Large rate enhancements and considerable nucleobase specificity in the catalytic transesterification of RNA dinucleotides are observed with the calix[4]arene enzyme mimic 1-Zn3 (the computer-generated model of the complex with GpG is shown). The higher activity toward GpG over ApA (factor of 160) originates from favorable substrate binding and cooperative catalytic action of all three ZnII ions. The heterotrinuclear metallo-phosphoesterase mimic 1-Zn2Cu is even more active.

KW - METIS-106257

KW - IR-11627

U2 - 10.1002/(SICI)1521-3773(19991102)38:21<3189::AID-ANIE3189>3.0.CO;2-X

DO - 10.1002/(SICI)1521-3773(19991102)38:21<3189::AID-ANIE3189>3.0.CO;2-X

M3 - Article

VL - 38

SP - 3189

EP - 3192

JO - Angewandte Chemie (international edition)

JF - Angewandte Chemie (international edition)

SN - 1433-7851

IS - 38

ER -