Specific RNA dinucleotide cleavage by a synthetic calix[4]arene-based trinuclear metallo(II)-phosphodiesterase

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Abstract

Large rate enhancements and considerable nucleobase specificity in the catalytic transesterification of RNA dinucleotides are observed with the calix[4]arene enzyme mimic 1-Zn3 (the computer-generated model of the complex with GpG is shown). The higher activity toward GpG over ApA (factor of 160) originates from favorable substrate binding and cooperative catalytic action of all three ZnII ions. The heterotrinuclear metallo-phosphoesterase mimic 1-Zn2Cu is even more active.
Original languageUndefined
Pages (from-to)3189-3192
JournalAngewandte Chemie (international edition)
Volume38
Issue number38
DOIs
Publication statusPublished - 1999

Keywords

  • METIS-106257
  • IR-11627

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