Abstract
Original language | Undefined |
---|---|
Pages (from-to) | 3189-3192 |
Journal | Angewandte Chemie (international edition) |
Volume | 38 |
Issue number | 38 |
DOIs | |
Publication status | Published - 1999 |
Keywords
- METIS-106257
- IR-11627
Cite this
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Specific RNA dinucleotide cleavage by a synthetic calix[4]arene-based trinuclear metallo(II)-phosphodiesterase. / Molenveld, P.; Engbersen, Johannes F.J.; Reinhoudt, David.
In: Angewandte Chemie (international edition), Vol. 38, No. 38, 1999, p. 3189-3192.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Specific RNA dinucleotide cleavage by a synthetic calix[4]arene-based trinuclear metallo(II)-phosphodiesterase
AU - Molenveld, P.
AU - Engbersen, Johannes F.J.
AU - Reinhoudt, David
PY - 1999
Y1 - 1999
N2 - Large rate enhancements and considerable nucleobase specificity in the catalytic transesterification of RNA dinucleotides are observed with the calix[4]arene enzyme mimic 1-Zn3 (the computer-generated model of the complex with GpG is shown). The higher activity toward GpG over ApA (factor of 160) originates from favorable substrate binding and cooperative catalytic action of all three ZnII ions. The heterotrinuclear metallo-phosphoesterase mimic 1-Zn2Cu is even more active.
AB - Large rate enhancements and considerable nucleobase specificity in the catalytic transesterification of RNA dinucleotides are observed with the calix[4]arene enzyme mimic 1-Zn3 (the computer-generated model of the complex with GpG is shown). The higher activity toward GpG over ApA (factor of 160) originates from favorable substrate binding and cooperative catalytic action of all three ZnII ions. The heterotrinuclear metallo-phosphoesterase mimic 1-Zn2Cu is even more active.
KW - METIS-106257
KW - IR-11627
U2 - 10.1002/(SICI)1521-3773(19991102)38:21<3189::AID-ANIE3189>3.0.CO;2-X
DO - 10.1002/(SICI)1521-3773(19991102)38:21<3189::AID-ANIE3189>3.0.CO;2-X
M3 - Article
VL - 38
SP - 3189
EP - 3192
JO - Angewandte Chemie (international edition)
JF - Angewandte Chemie (international edition)
SN - 1433-7851
IS - 38
ER -