The semantical insufficiency of (spatial) economic theories necessitates the making of additional assumptions — thereby introducing substantial specification uncertainty — in order to arrive at a fully specified econometric model. The traditional or current approach to econometric modelling treats specification uncertainty inadequately. This proposition is illustrated by two well-known examples from the spatial economic literature. Two alternative specification strategies for spatial economic modelling — designed to improve the current spatial econometric modelling approach — are proposed. One of these strategies is used for a specification analysis of agricultural output in Eire.