Spectral analysis of the EEG and 99m-Tc-HMPAO SPECT-scan in Alzheimer's disease

Vincent I.H. Kwa; Henri C. Weinstein; Eelco F. Posthumus Meyjes; Eric A. Van Royen; Lo J. Bour; Paul N.L.G. Verhoeff; Bram W. Ongerboer de Visser

doi:10.1016/0006-3223(93)90308-Z

Spectral analysis of the EEG and 99m-Tc-HMPAO SPECT-scan in Alzheimer's disease

Vincent I.H. Kwa^*
, Henri C. Weinstein
, Eelco F. Posthumus Meyjes
, Eric A. Van Royen
, Lo J. Bour
, Paul N.L.G. Verhoeff
, Bram W. Ongerboer de Visser

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

44 Citations (Scopus)

Abstract

99m-technetium-hexamethylpropylene-amineoxine (99m-Tc-HMPAO) single-photon-emission-computer-tomography (SPECT)-scans and spectral analyzed electroencephalogram (EEGs) of 20 patients with Alzheimer's disease (AD) were studied. A significant correlation was found between the temporoparietall-cerebellar-ratio (TP/C-ratio) of the SPECT-scan and the peak frequencies of leads T3-T5, C3-P3, and C4-P4 of the EEG. In addition a significant negative correlation between the TP/C-ratio and the theta/alpha-ratio (t/a-ratio) of leads T3-T5, T4-T6, C3-P3, and C4-P4 was demontrated. Our study demonstrates that slowing of the EEG parallels a decrease in blood flow in the temporoparietall regions in AD-patients. Both findings could be parallel phenomena of regional hypometabolism.

Original language	English
Pages (from-to)	100-107
Number of pages	8
Journal	Biological Psychiatry
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/0006-3223(93)90308-Z
Publication status	Published - 15 Jan 1993
Externally published	Yes

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@article{4b4588eac6ad419380eaaeb9c23b09e0,

title = "Spectral analysis of the EEG and 99m-Tc-HMPAO SPECT-scan in Alzheimer's disease",

abstract = "99m-technetium-hexamethylpropylene-amineoxine (99m-Tc-HMPAO) single-photon-emission-computer-tomography (SPECT)-scans and spectral analyzed electroencephalogram (EEGs) of 20 patients with Alzheimer's disease (AD) were studied. A significant correlation was found between the temporoparietall-cerebellar-ratio (TP/C-ratio) of the SPECT-scan and the peak frequencies of leads T3-T5, C3-P3, and C4-P4 of the EEG. In addition a significant negative correlation between the TP/C-ratio and the theta/alpha-ratio (t/a-ratio) of leads T3-T5, T4-T6, C3-P3, and C4-P4 was demontrated. Our study demonstrates that slowing of the EEG parallels a decrease in blood flow in the temporoparietall regions in AD-patients. Both findings could be parallel phenomena of regional hypometabolism.",

author = "Kwa, \{Vincent I.H.\} and Weinstein, \{Henri C.\} and \{Posthumus Meyjes\}, \{Eelco F.\} and \{Van Royen\}, \{Eric A.\} and Bour, \{Lo J.\} and Verhoeff, \{Paul N.L.G.\} and \{Ongerboer de Visser\}, \{Bram W.\}",

year = "1993",

month = jan,

day = "15",

doi = "10.1016/0006-3223(93)90308-Z",

language = "English",

volume = "33",

pages = "100--107",

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T1 - Spectral analysis of the EEG and 99m-Tc-HMPAO SPECT-scan in Alzheimer's disease

AU - Kwa, Vincent I.H.

AU - Weinstein, Henri C.

AU - Posthumus Meyjes, Eelco F.

AU - Van Royen, Eric A.

AU - Bour, Lo J.

AU - Verhoeff, Paul N.L.G.

AU - Ongerboer de Visser, Bram W.

PY - 1993/1/15

Y1 - 1993/1/15

N2 - 99m-technetium-hexamethylpropylene-amineoxine (99m-Tc-HMPAO) single-photon-emission-computer-tomography (SPECT)-scans and spectral analyzed electroencephalogram (EEGs) of 20 patients with Alzheimer's disease (AD) were studied. A significant correlation was found between the temporoparietall-cerebellar-ratio (TP/C-ratio) of the SPECT-scan and the peak frequencies of leads T3-T5, C3-P3, and C4-P4 of the EEG. In addition a significant negative correlation between the TP/C-ratio and the theta/alpha-ratio (t/a-ratio) of leads T3-T5, T4-T6, C3-P3, and C4-P4 was demontrated. Our study demonstrates that slowing of the EEG parallels a decrease in blood flow in the temporoparietall regions in AD-patients. Both findings could be parallel phenomena of regional hypometabolism.

AB - 99m-technetium-hexamethylpropylene-amineoxine (99m-Tc-HMPAO) single-photon-emission-computer-tomography (SPECT)-scans and spectral analyzed electroencephalogram (EEGs) of 20 patients with Alzheimer's disease (AD) were studied. A significant correlation was found between the temporoparietall-cerebellar-ratio (TP/C-ratio) of the SPECT-scan and the peak frequencies of leads T3-T5, C3-P3, and C4-P4 of the EEG. In addition a significant negative correlation between the TP/C-ratio and the theta/alpha-ratio (t/a-ratio) of leads T3-T5, T4-T6, C3-P3, and C4-P4 was demontrated. Our study demonstrates that slowing of the EEG parallels a decrease in blood flow in the temporoparietall regions in AD-patients. Both findings could be parallel phenomena of regional hypometabolism.

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AN - SCOPUS:0027522888

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JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 2

ER -

Spectral analysis of the EEG and 99m-Tc-HMPAO SPECT-scan in Alzheimer's disease

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