Spectroscopic low coherence interferometry

Nienke Bosschaart, Ton van Leeuwen, M.C.G. Aalders, B. Hermann, W. Drexler, D.J. Faber

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

1 Citation (Scopus)


Low-coherence interferometry (LCI) allows high-resolution volumetric imaging of tissue morphology and provides localized optical properties that can be related to the physiological status of tissue. This chapter discusses the combination of spatial and spectroscopic information by means of spectroscopic OCT (sOCT) and low-coherence spectroscopy (LCS). We describe the theory behind these modalities for the assessment of spatially resolved optical absorption and (back)scattering coefficient spectra. These spectra can be used for the highly localized quantification of chromophore concentrations and assessment of tissue organization on (sub)cellular scales. This leads to a wealth of potential clinical applications, ranging from neonatology for the determination of billibrubin concentrations, to oncology for the optical assessment of the aggressiveness of a cancerous lesion
Original languageEnglish
Title of host publicationOptical Coherence Tomography
EditorsW. Drexler, J.G. Fujimoto
Number of pages25
ISBN (Print)978-3-319-06418-5
Publication statusPublished - 2015

Publication series

PublisherSpringer International Publishing


  • NLA


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