Spectroscopic low coherence interferometry

Nienke Bosschaart, Ton van Leeuwen, M.C.G. Aalders, B. Hermann, W. Drexler, D.J. Faber

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

Low-coherence interferometry (LCI) allows high-resolution volumetric imaging of tissue morphology and provides localized optical properties that can be related to the physiological status of tissue. This chapter discusses the combination of spatial and spectroscopic information by means of spectroscopic OCT (sOCT) and low-coherence spectroscopy (LCS). We describe the theory behind these modalities for the assessment of spatially resolved optical absorption and (back)scattering coefficient spectra. These spectra can be used for the highly localized quantification of chromophore concentrations and assessment of tissue organization on (sub)cellular scales. This leads to a wealth of potential clinical applications, ranging from neonatology for the determination of billibrubin concentrations, to oncology for the optical assessment of the aggressiveness of a cancerous lesion
Original languageEnglish
Title of host publicationOptical Coherence Tomography
EditorsW. Drexler, J.G. Fujimoto
PublisherSpringer
Pages1163-1187
Number of pages25
ISBN (Print)978-3-319-06418-5
DOIs
Publication statusPublished - 2015

Publication series

Name
PublisherSpringer International Publishing

Fingerprint

Interferometry
Tissue
Oncology
Chromophores
Light absorption
Optical properties
Spectroscopy
Scattering
Imaging techniques

Keywords

  • METIS-311598
  • IR-97566

Cite this

Bosschaart, N., van Leeuwen, T., Aalders, M. C. G., Hermann, B., Drexler, W., & Faber, D. J. (2015). Spectroscopic low coherence interferometry. In W. Drexler, & J. G. Fujimoto (Eds.), Optical Coherence Tomography (pp. 1163-1187). Springer. https://doi.org/10.1007/978-3-319-06419-2_37
Bosschaart, Nienke ; van Leeuwen, Ton ; Aalders, M.C.G. ; Hermann, B. ; Drexler, W. ; Faber, D.J. / Spectroscopic low coherence interferometry. Optical Coherence Tomography. editor / W. Drexler ; J.G. Fujimoto. Springer, 2015. pp. 1163-1187
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Bosschaart, N, van Leeuwen, T, Aalders, MCG, Hermann, B, Drexler, W & Faber, DJ 2015, Spectroscopic low coherence interferometry. in W Drexler & JG Fujimoto (eds), Optical Coherence Tomography. Springer, pp. 1163-1187. https://doi.org/10.1007/978-3-319-06419-2_37

Spectroscopic low coherence interferometry. / Bosschaart, Nienke; van Leeuwen, Ton; Aalders, M.C.G.; Hermann, B.; Drexler, W.; Faber, D.J.

Optical Coherence Tomography. ed. / W. Drexler; J.G. Fujimoto. Springer, 2015. p. 1163-1187.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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T1 - Spectroscopic low coherence interferometry

AU - Bosschaart, Nienke

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AU - Faber, D.J.

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N2 - Low-coherence interferometry (LCI) allows high-resolution volumetric imaging of tissue morphology and provides localized optical properties that can be related to the physiological status of tissue. This chapter discusses the combination of spatial and spectroscopic information by means of spectroscopic OCT (sOCT) and low-coherence spectroscopy (LCS). We describe the theory behind these modalities for the assessment of spatially resolved optical absorption and (back)scattering coefficient spectra. These spectra can be used for the highly localized quantification of chromophore concentrations and assessment of tissue organization on (sub)cellular scales. This leads to a wealth of potential clinical applications, ranging from neonatology for the determination of billibrubin concentrations, to oncology for the optical assessment of the aggressiveness of a cancerous lesion

AB - Low-coherence interferometry (LCI) allows high-resolution volumetric imaging of tissue morphology and provides localized optical properties that can be related to the physiological status of tissue. This chapter discusses the combination of spatial and spectroscopic information by means of spectroscopic OCT (sOCT) and low-coherence spectroscopy (LCS). We describe the theory behind these modalities for the assessment of spatially resolved optical absorption and (back)scattering coefficient spectra. These spectra can be used for the highly localized quantification of chromophore concentrations and assessment of tissue organization on (sub)cellular scales. This leads to a wealth of potential clinical applications, ranging from neonatology for the determination of billibrubin concentrations, to oncology for the optical assessment of the aggressiveness of a cancerous lesion

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Bosschaart N, van Leeuwen T, Aalders MCG, Hermann B, Drexler W, Faber DJ. Spectroscopic low coherence interferometry. In Drexler W, Fujimoto JG, editors, Optical Coherence Tomography. Springer. 2015. p. 1163-1187 https://doi.org/10.1007/978-3-319-06419-2_37