Spinal shape modulation in a porcine model by a highly flexible and extendable non-fusion implant system

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Abstract

Purpose In vivo evaluation of scoliosis treatment using a novel approach in which two posterior implants are implanted: XSLAT (eXtendable implant correcting Scoliosis in LAT bending) and XSTOR (eXtendable implant correcting Scoliosis in TORsion). The highly flexible and extendable implants use only small, but continuous lateral forces (XSLAT) and torques (XSTOR), thereby allowing growth and preventing fusion. Methods Since (idiopathic) scoliosis does not occur spontaneously in animals, the device was used to induce a spinal deformity rather than correct it. Six of each implants were tested for their ability to induce scoliotic deformations in 12 growing pigs. Each implant spanned six segments and was attached to three vertebrae using sliding anchors. Radiological and histological assessments were done throughout the 8-week study. Results In all animals, the intended deformation was accomplished. Average Cobb angles were 19° for XSLAT and 6° for XSTOR. Average apical spinal torsion was 0° for XSLAT and 9° for XSTOR. All instrumented segments remained mobile and showed 20 % growth. Moderate degeneration of the facet joints was observed and some debris was found in the surrounding tissue. Conclusions The approach accomplished the intended spinal deformation while allowing growth and preventing fusion.
Original languageEnglish
Pages (from-to)2975-2983
Number of pages9
JournalEuropean spine journal
Volume25
Issue number9
DOIs
Publication statusPublished - 2016

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Torque
Scoliosis
Swine
Growth
Zygapophyseal Joint
Spine
Equipment and Supplies

Keywords

  • METIS-317900
  • IR-104325

Cite this

@article{6d2e4baf3c1b4f3484f6cac715527f10,
title = "Spinal shape modulation in a porcine model by a highly flexible and extendable non-fusion implant system",
abstract = "Purpose In vivo evaluation of scoliosis treatment using a novel approach in which two posterior implants are implanted: XSLAT (eXtendable implant correcting Scoliosis in LAT bending) and XSTOR (eXtendable implant correcting Scoliosis in TORsion). The highly flexible and extendable implants use only small, but continuous lateral forces (XSLAT) and torques (XSTOR), thereby allowing growth and preventing fusion. Methods Since (idiopathic) scoliosis does not occur spontaneously in animals, the device was used to induce a spinal deformity rather than correct it. Six of each implants were tested for their ability to induce scoliotic deformations in 12 growing pigs. Each implant spanned six segments and was attached to three vertebrae using sliding anchors. Radiological and histological assessments were done throughout the 8-week study. Results In all animals, the intended deformation was accomplished. Average Cobb angles were 19° for XSLAT and 6° for XSTOR. Average apical spinal torsion was 0° for XSLAT and 9° for XSTOR. All instrumented segments remained mobile and showed 20 {\%} growth. Moderate degeneration of the facet joints was observed and some debris was found in the surrounding tissue. Conclusions The approach accomplished the intended spinal deformation while allowing growth and preventing fusion.",
keywords = "METIS-317900, IR-104325",
author = "Martijn Wessels and Hekman, {Edsko E.G.} and M.C. Kruyt and R.M. Castelein and Homminga, {Jasper Johan} and Verkerke, {Gijsbertus Jacob}",
note = "Open access",
year = "2016",
doi = "10.1007/s00586-016-4570-9",
language = "English",
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pages = "2975--2983",
journal = "European spine journal",
issn = "0940-6719",
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Spinal shape modulation in a porcine model by a highly flexible and extendable non-fusion implant system. / Wessels, Martijn; Hekman, Edsko E.G.; Kruyt, M.C.; Castelein, R.M.; Homminga, Jasper Johan; Verkerke, Gijsbertus Jacob.

In: European spine journal, Vol. 25, No. 9, 2016, p. 2975-2983.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Spinal shape modulation in a porcine model by a highly flexible and extendable non-fusion implant system

AU - Wessels, Martijn

AU - Hekman, Edsko E.G.

AU - Kruyt, M.C.

AU - Castelein, R.M.

AU - Homminga, Jasper Johan

AU - Verkerke, Gijsbertus Jacob

N1 - Open access

PY - 2016

Y1 - 2016

N2 - Purpose In vivo evaluation of scoliosis treatment using a novel approach in which two posterior implants are implanted: XSLAT (eXtendable implant correcting Scoliosis in LAT bending) and XSTOR (eXtendable implant correcting Scoliosis in TORsion). The highly flexible and extendable implants use only small, but continuous lateral forces (XSLAT) and torques (XSTOR), thereby allowing growth and preventing fusion. Methods Since (idiopathic) scoliosis does not occur spontaneously in animals, the device was used to induce a spinal deformity rather than correct it. Six of each implants were tested for their ability to induce scoliotic deformations in 12 growing pigs. Each implant spanned six segments and was attached to three vertebrae using sliding anchors. Radiological and histological assessments were done throughout the 8-week study. Results In all animals, the intended deformation was accomplished. Average Cobb angles were 19° for XSLAT and 6° for XSTOR. Average apical spinal torsion was 0° for XSLAT and 9° for XSTOR. All instrumented segments remained mobile and showed 20 % growth. Moderate degeneration of the facet joints was observed and some debris was found in the surrounding tissue. Conclusions The approach accomplished the intended spinal deformation while allowing growth and preventing fusion.

AB - Purpose In vivo evaluation of scoliosis treatment using a novel approach in which two posterior implants are implanted: XSLAT (eXtendable implant correcting Scoliosis in LAT bending) and XSTOR (eXtendable implant correcting Scoliosis in TORsion). The highly flexible and extendable implants use only small, but continuous lateral forces (XSLAT) and torques (XSTOR), thereby allowing growth and preventing fusion. Methods Since (idiopathic) scoliosis does not occur spontaneously in animals, the device was used to induce a spinal deformity rather than correct it. Six of each implants were tested for their ability to induce scoliotic deformations in 12 growing pigs. Each implant spanned six segments and was attached to three vertebrae using sliding anchors. Radiological and histological assessments were done throughout the 8-week study. Results In all animals, the intended deformation was accomplished. Average Cobb angles were 19° for XSLAT and 6° for XSTOR. Average apical spinal torsion was 0° for XSLAT and 9° for XSTOR. All instrumented segments remained mobile and showed 20 % growth. Moderate degeneration of the facet joints was observed and some debris was found in the surrounding tissue. Conclusions The approach accomplished the intended spinal deformation while allowing growth and preventing fusion.

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