Stabilization of inverse miniemulsions by silyl-protected homopolymers

Sarah Wald, Frederik R. Wurm, Katharina Landfester*, Daniel Crespy*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
3 Downloads (Pure)


Inverse (water-in-oil) miniemulsions are an important method to encapsulate hydrophilic payloads such as oligonucleotides or peptides. However, the stabilization of inverse miniemulsions usually requires block copolymers that are difficult to synthesize and/or cannot be easily removed after transfer from a hydrophobic continuous phase to an aqueous continuous phase. We describe here a new strategy for the synthesis of a surfactant for inverse miniemulsions by radical addition-fragmentation chain transfer (RAFT) polymerization, which consists in a homopolymer with triisopropylsilyl protecting groups. The protecting groups ensure the efficient stabilization of the inverse (water-in-oil, w/o) miniemulsions. Nanocapsules can be formed and the protecting group can be subsequently cleaved for the re-dispersion of nanocapsules in an aqueous medium with a minimal amount of additional surfactant.

Original languageEnglish
Article number303
Issue number8
Publication statusPublished - 12 Aug 2016
Externally publishedYes


  • Miniemulsion
  • Nanocapsules
  • Phase transfer
  • Radical addition fragmentation transfer polymerization
  • Surfactant


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