Stabilization of nanoparticles synthesized by miniemulsion polymerization using "green" amino-acid based surfactants

Grit Baier, Abdulkader Baki, Stephanie Tomcin, Volker Mailänder, Evandro Alexandrino, Frederik Wurm, Katharina Landfester*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)


In this study biocompatible amino-acid based surfactants were used for the stabilization of polystyrene (PS), poly(L-lactide) (PLLA) and polyphosphate (PP) nanoparticles (NPs). The formation of the nanoparticles was achieved either by radical polymerization in miniemulsion for polystyrene nanoparticles or by using a combination of solvent evaporation and miniemulsion approach for poly(L-lactide) or polyphosphate nanoparticles. The influence of the three different amino-acid based surfactants, which were used with different amounts, on the NPs' stability, size, size distribution, zeta potential, morphology and surface tension is discussed. Cell experiments with HeLa cells were performed for the determination of the toxicity. For comparison, sodium dodecyl sulfate (SDS) stabilized NPs were synthesized, and all results obtained from the amino-acid based surfactant stabilized NPs were compared and discussed with the SDS stabilized NPs.

Original languageEnglish
Pages (from-to)9-17
Number of pages9
JournalMacromolecular symposia
Issue number1
Publication statusPublished - Mar 2014
Externally publishedYes


  • miniemulsion polymerization
  • polystyrene
  • stabilization
  • surfactants


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