Standardized and modular microfluidic platform for fast Lab on Chip system development

S. Dekker, W. Buesink, M. Blom, M. Alessio, N. Verplanck, M. Hihoud, C. Dehan, W. César, A. Le Nel, A. van den Berg, M. Odijk* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Since the Lab on a Chip concept was introduced in the 1990s, a lot of scientific advancements have occurred. However, large scale commercial realization of microfluidic technology is being prevented by the lack of standardization. There seems to be a gap between Lab on a Chip systems developed in the lab and those that are manufacturable on a large scale in a fab. In this paper, we propose a modular platform which makes use of standardized parts. Using this platform, a functional-based method of designing microfluidic systems is envisioned. To obtain a certain microfluidic function, a bottom-up design is made. This results in micro fluidic building blocks that perform a microfluidic function. This microfluidic building block is then stored in a library, ready for reuse in the future. Key characteristics are shown for several basic microfluidic building blocks, developed according to a footprint and interconnect standard by various players in the microfluidic world. Such a library of reusable and interoperable microfluidic building blocks is important to fill the gap between lab and fab, as it reduces the time-to-market by lowering prototype time cycles. The wide support of key European players active in microfluidics, which is shown by an ISO workshop agreement (IWA 23:2016), makes this approach more likely to succeed compared to earlier attempts in modular microfluidics.

Original languageEnglish
Pages (from-to)468-478
Number of pages11
JournalSensors and actuators. B: Chemical
Early online date22 Apr 2018
Publication statusPublished - 1 Nov 2018


  • Characterization
  • Commercialization
  • Microfluidic design
  • Microfluidic standardization
  • Modular
  • Platform

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