Standardized and modular microfluidic platform for fast Lab on Chip system development

S. Dekker, W. Buesink, M. Blom, M. Alessio, N. Verplanck, M. Hihoud, C. Dehan, W. César, A. Le Nel, A. van den Berg, M. Odijk* (Corresponding Author)

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    4 Citations (Scopus)
    45 Downloads (Pure)

    Abstract

    Since the Lab on a Chip concept was introduced in the 1990s, a lot of scientific advancements have occurred. However, large scale commercial realization of microfluidic technology is being prevented by the lack of standardization. There seems to be a gap between Lab on a Chip systems developed in the lab and those that are manufacturable on a large scale in a fab. In this paper, we propose a modular platform which makes use of standardized parts. Using this platform, a functional-based method of designing microfluidic systems is envisioned. To obtain a certain microfluidic function, a bottom-up design is made. This results in micro fluidic building blocks that perform a microfluidic function. This microfluidic building block is then stored in a library, ready for reuse in the future. Key characteristics are shown for several basic microfluidic building blocks, developed according to a footprint and interconnect standard by various players in the microfluidic world. Such a library of reusable and interoperable microfluidic building blocks is important to fill the gap between lab and fab, as it reduces the time-to-market by lowering prototype time cycles. The wide support of key European players active in microfluidics, which is shown by an ISO workshop agreement (IWA 23:2016), makes this approach more likely to succeed compared to earlier attempts in modular microfluidics.

    Original languageEnglish
    Pages (from-to)468-478
    Number of pages11
    JournalSensors and actuators. B: Chemical
    Volume272
    Early online date22 Apr 2018
    DOIs
    Publication statusPublished - 1 Nov 2018

    Fingerprint

    Microfluidics
    platforms
    chips
    systems-on-a-chip
    reuse
    fluidics
    standardization
    footprints
    Lab-on-a-chip
    prototypes
    cycles
    System-on-chip
    Fluidics
    Standardization

    Keywords

    • Characterization
    • Commercialization
    • Microfluidic design
    • Microfluidic standardization
    • Modular
    • Platform

    Cite this

    Dekker, S. ; Buesink, W. ; Blom, M. ; Alessio, M. ; Verplanck, N. ; Hihoud, M. ; Dehan, C. ; César, W. ; Le Nel, A. ; van den Berg, A. ; Odijk, M. / Standardized and modular microfluidic platform for fast Lab on Chip system development. In: Sensors and actuators. B: Chemical. 2018 ; Vol. 272. pp. 468-478.
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    abstract = "Since the Lab on a Chip concept was introduced in the 1990s, a lot of scientific advancements have occurred. However, large scale commercial realization of microfluidic technology is being prevented by the lack of standardization. There seems to be a gap between Lab on a Chip systems developed in the lab and those that are manufacturable on a large scale in a fab. In this paper, we propose a modular platform which makes use of standardized parts. Using this platform, a functional-based method of designing microfluidic systems is envisioned. To obtain a certain microfluidic function, a bottom-up design is made. This results in micro fluidic building blocks that perform a microfluidic function. This microfluidic building block is then stored in a library, ready for reuse in the future. Key characteristics are shown for several basic microfluidic building blocks, developed according to a footprint and interconnect standard by various players in the microfluidic world. Such a library of reusable and interoperable microfluidic building blocks is important to fill the gap between lab and fab, as it reduces the time-to-market by lowering prototype time cycles. The wide support of key European players active in microfluidics, which is shown by an ISO workshop agreement (IWA 23:2016), makes this approach more likely to succeed compared to earlier attempts in modular microfluidics.",
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    Dekker, S, Buesink, W, Blom, M, Alessio, M, Verplanck, N, Hihoud, M, Dehan, C, César, W, Le Nel, A, van den Berg, A & Odijk, M 2018, 'Standardized and modular microfluidic platform for fast Lab on Chip system development', Sensors and actuators. B: Chemical, vol. 272, pp. 468-478. https://doi.org/10.1016/j.snb.2018.04.005

    Standardized and modular microfluidic platform for fast Lab on Chip system development. / Dekker, S.; Buesink, W.; Blom, M.; Alessio, M.; Verplanck, N.; Hihoud, M.; Dehan, C.; César, W.; Le Nel, A.; van den Berg, A.; Odijk, M. (Corresponding Author).

    In: Sensors and actuators. B: Chemical, Vol. 272, 01.11.2018, p. 468-478.

    Research output: Contribution to journalArticleAcademicpeer-review

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    AU - Blom, M.

    AU - Alessio, M.

    AU - Verplanck, N.

    AU - Hihoud, M.

    AU - Dehan, C.

    AU - César, W.

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