Standardized, modular microfluidic building blocks for automated cell culturing systems

Anke Vollertsen*, Elsbeth Bossink, Dean de Boer, Jet Spalink, Robert Passier, Albert van den Berg, Loes Segerink, Andries van der Meer, Mathieu Odijk

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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Abstract

We report an emerging toolkit of modular and standardized MicroFluidic Building Blocks (MFBB) to ultimately form a versatile and automated system on a Fluidic Circuit Board (FCB) for high-throughput cell culturing and screening assays. The toolkit is composed of four different MFBBs to meet a total of four different purposes: (1) a metering and mixing MFBB for upstream sample preparation, (2) a gut-on-a-chip MFBB for increased biological complexity, (3) a 64-chamber MFBB for multiplexed cell culturing, and (4) a cell-in-droplet encapsulation MFBB for downstream analysis preparation.
Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
EditorsPetra Diettrich, Emanuelle Delamarche, Andreas Hierlemann
Place of PublicationBasel, Switzerland
PublisherChemical and Biological Micro Systems Society
Pages86-87
Number of pages2
Edition23
ISBN (Electronic)978-1-7334190-0-0
Publication statusPublished - 28 Oct 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 - Congress Center Basel, Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019
Conference number: 23
https://cbmsociety.org/microtas/microtas2019/

Publication series

Name
ISSN (Print)1556-5904

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019
Abbreviated titleMicroTAS 2019
CountrySwitzerland
CityBasel
Period27/10/1931/10/19
Internet address

Fingerprint

Microfluidics
Fluidics
Encapsulation
Assays
Screening
Throughput
Networks (circuits)

Keywords

  • Modular
  • Standardization
  • automation
  • Microfluidic building blocks

Cite this

Vollertsen, A., Bossink, E., de Boer, D., Spalink, J., Passier, R., van den Berg, A., ... Odijk, M. (2019). Standardized, modular microfluidic building blocks for automated cell culturing systems. In P. Diettrich, E. Delamarche, & A. Hierlemann (Eds.), 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (23 ed., pp. 86-87). Basel, Switzerland: Chemical and Biological Micro Systems Society.
Vollertsen, Anke ; Bossink, Elsbeth ; de Boer, Dean ; Spalink, Jet ; Passier, Robert ; van den Berg, Albert ; Segerink, Loes ; van der Meer, Andries ; Odijk, Mathieu . / Standardized, modular microfluidic building blocks for automated cell culturing systems. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. editor / Petra Diettrich ; Emanuelle Delamarche ; Andreas Hierlemann. 23. ed. Basel, Switzerland : Chemical and Biological Micro Systems Society, 2019. pp. 86-87
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title = "Standardized, modular microfluidic building blocks for automated cell culturing systems",
abstract = "We report an emerging toolkit of modular and standardized MicroFluidic Building Blocks (MFBB) to ultimately form a versatile and automated system on a Fluidic Circuit Board (FCB) for high-throughput cell culturing and screening assays. The toolkit is composed of four different MFBBs to meet a total of four different purposes: (1) a metering and mixing MFBB for upstream sample preparation, (2) a gut-on-a-chip MFBB for increased biological complexity, (3) a 64-chamber MFBB for multiplexed cell culturing, and (4) a cell-in-droplet encapsulation MFBB for downstream analysis preparation.",
keywords = "Modular, Standardization, automation, Microfluidic building blocks",
author = "Anke Vollertsen and Elsbeth Bossink and {de Boer}, Dean and Jet Spalink and Robert Passier and {van den Berg}, Albert and Loes Segerink and {van der Meer}, Andries and Mathieu Odijk",
year = "2019",
month = "10",
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publisher = "Chemical and Biological Micro Systems Society",
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Vollertsen, A, Bossink, E, de Boer, D, Spalink, J, Passier, R, van den Berg, A, Segerink, L, van der Meer, A & Odijk, M 2019, Standardized, modular microfluidic building blocks for automated cell culturing systems. in P Diettrich, E Delamarche & A Hierlemann (eds), 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23 edn, Chemical and Biological Micro Systems Society, Basel, Switzerland, pp. 86-87, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019, Basel, Switzerland, 27/10/19.

Standardized, modular microfluidic building blocks for automated cell culturing systems. / Vollertsen, Anke; Bossink, Elsbeth; de Boer, Dean; Spalink, Jet; Passier, Robert; van den Berg, Albert ; Segerink, Loes; van der Meer, Andries; Odijk, Mathieu .

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. ed. / Petra Diettrich; Emanuelle Delamarche; Andreas Hierlemann. 23. ed. Basel, Switzerland : Chemical and Biological Micro Systems Society, 2019. p. 86-87.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

TY - GEN

T1 - Standardized, modular microfluidic building blocks for automated cell culturing systems

AU - Vollertsen, Anke

AU - Bossink, Elsbeth

AU - de Boer, Dean

AU - Spalink, Jet

AU - Passier, Robert

AU - van den Berg, Albert

AU - Segerink, Loes

AU - van der Meer, Andries

AU - Odijk, Mathieu

PY - 2019/10/28

Y1 - 2019/10/28

N2 - We report an emerging toolkit of modular and standardized MicroFluidic Building Blocks (MFBB) to ultimately form a versatile and automated system on a Fluidic Circuit Board (FCB) for high-throughput cell culturing and screening assays. The toolkit is composed of four different MFBBs to meet a total of four different purposes: (1) a metering and mixing MFBB for upstream sample preparation, (2) a gut-on-a-chip MFBB for increased biological complexity, (3) a 64-chamber MFBB for multiplexed cell culturing, and (4) a cell-in-droplet encapsulation MFBB for downstream analysis preparation.

AB - We report an emerging toolkit of modular and standardized MicroFluidic Building Blocks (MFBB) to ultimately form a versatile and automated system on a Fluidic Circuit Board (FCB) for high-throughput cell culturing and screening assays. The toolkit is composed of four different MFBBs to meet a total of four different purposes: (1) a metering and mixing MFBB for upstream sample preparation, (2) a gut-on-a-chip MFBB for increased biological complexity, (3) a 64-chamber MFBB for multiplexed cell culturing, and (4) a cell-in-droplet encapsulation MFBB for downstream analysis preparation.

KW - Modular

KW - Standardization

KW - automation

KW - Microfluidic building blocks

M3 - Conference contribution

SP - 86

EP - 87

BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences

A2 - Diettrich, Petra

A2 - Delamarche, Emanuelle

A2 - Hierlemann, Andreas

PB - Chemical and Biological Micro Systems Society

CY - Basel, Switzerland

ER -

Vollertsen A, Bossink E, de Boer D, Spalink J, Passier R, van den Berg A et al. Standardized, modular microfluidic building blocks for automated cell culturing systems. In Diettrich P, Delamarche E, Hierlemann A, editors, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23 ed. Basel, Switzerland: Chemical and Biological Micro Systems Society. 2019. p. 86-87