Standardized, modular microfluidic building blocks for automated cell culturing systems

Anke Vollertsen; Elsbeth Bossink; Dean de Boer; Jet Spalink; Robert Passier; Albert  van den Berg; Loes Segerink; Andries van der Meer; Mathieu  Odijk

Standardized, modular microfluidic building blocks for automated cell culturing systems

Anke Vollertsen^*, Elsbeth Bossink, Dean de Boer, Jet Spalink, Robert Passier, Albert van den Berg, Loes Segerink, Andries van der Meer, Mathieu Odijk

^*Corresponding author for this work

Applied Stem Cell Technologies

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

We report an emerging toolkit of modular and standardized MicroFluidic Building Blocks (MFBB) to ultimately form a versatile and automated system on a Fluidic Circuit Board (FCB) for high-throughput cell culturing and screening assays. The toolkit is composed of four different MFBBs to meet a total of four different purposes: (1) a metering and mixing MFBB for upstream sample preparation, (2) a gut-on-a-chip MFBB for increased biological complexity, (3) a 64-chamber MFBB for multiplexed cell culturing, and (4) a cell-in-droplet encapsulation MFBB for downstream analysis preparation.

Original language	English
Title of host publication	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
Editors	Petra Diettrich, Emanuelle Delamarche, Andreas Hierlemann
Place of Publication	Basel, Switzerland
Publisher	The Chemical and Biological Microsystems Society
Pages	86-87
Number of pages	2
Edition	23
ISBN (Electronic)	978-1-7334190-0-0
Publication status	Published - 28 Oct 2019
Event	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 - Congress Center Basel, Basel, Switzerland Duration: 27 Oct 2019 → 31 Oct 2019 Conference number: 23 https://cbmsociety.org/microtas/microtas2019/

Conference

Conference	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019
Abbreviated title	MicroTAS 2019
Country/Territory	Switzerland
City	Basel
Period	27/10/19 → 31/10/19
Internet address	https://cbmsociety.org/microtas/microtas2019/

Keywords

Modular
Standardization
automation
Microfluidic building blocks

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uTas2019 - AnkeFinal published version, 765 KBLicence: Taverne

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Vollertsen, A., Bossink, E., de Boer, D., Spalink, J., Passier, R., van den Berg, A., Segerink, L., van der Meer, A., & Odijk, M. (2019). Standardized, modular microfluidic building blocks for automated cell culturing systems. In P. Diettrich, E. Delamarche, & A. Hierlemann (Eds.), 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (23 ed., pp. 86-87). The Chemical and Biological Microsystems Society.

Vollertsen, Anke ; Bossink, Elsbeth ; de Boer, Dean et al. / Standardized, modular microfluidic building blocks for automated cell culturing systems. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. editor / Petra Diettrich ; Emanuelle Delamarche ; Andreas Hierlemann. 23. ed. Basel, Switzerland : The Chemical and Biological Microsystems Society, 2019. pp. 86-87

@inproceedings{cbca7481a9f0426c88974daa30acfe73,

title = "Standardized, modular microfluidic building blocks for automated cell culturing systems",

abstract = "We report an emerging toolkit of modular and standardized MicroFluidic Building Blocks (MFBB) to ultimately form a versatile and automated system on a Fluidic Circuit Board (FCB) for high-throughput cell culturing and screening assays. The toolkit is composed of four different MFBBs to meet a total of four different purposes: (1) a metering and mixing MFBB for upstream sample preparation, (2) a gut-on-a-chip MFBB for increased biological complexity, (3) a 64-chamber MFBB for multiplexed cell culturing, and (4) a cell-in-droplet encapsulation MFBB for downstream analysis preparation.",

keywords = "Modular, Standardization, automation, Microfluidic building blocks",

author = "Anke Vollertsen and Elsbeth Bossink and {de Boer}, Dean and Jet Spalink and Robert Passier and {van den Berg}, Albert and Loes Segerink and {van der Meer}, Andries and Mathieu Odijk",

year = "2019",

month = oct,

day = "28",

language = "English",

pages = "86--87",

editor = "Petra Diettrich and Emanuelle Delamarche and Andreas Hierlemann",

booktitle = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "The Chemical and Biological Microsystems Society",

edition = "23",

note = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019, MicroTAS 2019 ; Conference date: 27-10-2019 Through 31-10-2019",

url = "https://cbmsociety.org/microtas/microtas2019/",

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Vollertsen, A, Bossink, E, de Boer, D, Spalink, J, Passier, R , van den Berg, A , Segerink, L , van der Meer, A & Odijk, M 2019, Standardized, modular microfluidic building blocks for automated cell culturing systems. in P Diettrich, E Delamarche & A Hierlemann (eds), 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23 edn, The Chemical and Biological Microsystems Society, Basel, Switzerland, pp. 86-87, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019, Basel, Switzerland, 27/10/19.

Standardized, modular microfluidic building blocks for automated cell culturing systems. / Vollertsen, Anke; Bossink, Elsbeth; de Boer, Dean et al.
23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. ed. / Petra Diettrich; Emanuelle Delamarche; Andreas Hierlemann. 23. ed. Basel, Switzerland: The Chemical and Biological Microsystems Society, 2019. p. 86-87.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Standardized, modular microfluidic building blocks for automated cell culturing systems

AU - Vollertsen, Anke

AU - Bossink, Elsbeth

AU - de Boer, Dean

AU - Spalink, Jet

AU - Passier, Robert

AU - van den Berg, Albert

AU - Segerink, Loes

AU - van der Meer, Andries

AU - Odijk, Mathieu

N1 - Conference code: 23

PY - 2019/10/28

Y1 - 2019/10/28

N2 - We report an emerging toolkit of modular and standardized MicroFluidic Building Blocks (MFBB) to ultimately form a versatile and automated system on a Fluidic Circuit Board (FCB) for high-throughput cell culturing and screening assays. The toolkit is composed of four different MFBBs to meet a total of four different purposes: (1) a metering and mixing MFBB for upstream sample preparation, (2) a gut-on-a-chip MFBB for increased biological complexity, (3) a 64-chamber MFBB for multiplexed cell culturing, and (4) a cell-in-droplet encapsulation MFBB for downstream analysis preparation.

AB - We report an emerging toolkit of modular and standardized MicroFluidic Building Blocks (MFBB) to ultimately form a versatile and automated system on a Fluidic Circuit Board (FCB) for high-throughput cell culturing and screening assays. The toolkit is composed of four different MFBBs to meet a total of four different purposes: (1) a metering and mixing MFBB for upstream sample preparation, (2) a gut-on-a-chip MFBB for increased biological complexity, (3) a 64-chamber MFBB for multiplexed cell culturing, and (4) a cell-in-droplet encapsulation MFBB for downstream analysis preparation.

KW - Modular

KW - Standardization

KW - automation

KW - Microfluidic building blocks

M3 - Conference contribution

SP - 86

EP - 87

BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences

A2 - Diettrich, Petra

A2 - Delamarche, Emanuelle

A2 - Hierlemann, Andreas

PB - The Chemical and Biological Microsystems Society

CY - Basel, Switzerland

T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019

Y2 - 27 October 2019 through 31 October 2019

ER -

Vollertsen A, Bossink E, de Boer D, Spalink J, Passier R , van den Berg A et al. Standardized, modular microfluidic building blocks for automated cell culturing systems. In Diettrich P, Delamarche E, Hierlemann A, editors, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23 ed. Basel, Switzerland: The Chemical and Biological Microsystems Society. 2019. p. 86-87

Standardized, modular microfluidic building blocks for automated cell culturing systems

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Conference

Keywords

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