Stereocomplex mediated gelation of PEG-(PLA)2 and PEG(PLA)8 block copolymers

C. Hiemstra; Zhiyuan Zhong; Pieter J. Dijkstra; Jan Feijen

doi:10.1002/masy.200550611

Stereocomplex mediated gelation of PEG-(PLA)2 and PEG(PLA)8 block copolymers

C. Hiemstra, Zhiyuan Zhong, Pieter J. Dijkstra, Jan Feijen

Research output: Contribution to journal › Article › Academic › peer-review

64 Citations (Scopus)

Abstract

Stereocomplex mediated hydrogels have been prepared by mixing solutions of polymers of opposite chirality of either PEG-(PLA)2 triblock copolymers or PEG-(PLA)8 star block copolymers. The critical gel concentrations of the mixed enantiomer solutions were considerably lower compared to polymer solutions containing only the single enantiomer. Moreover, gel-sol transition temperatures were increased and gel regions were expanded due to stereocomplexation. Rheology measurements showed that stereocomplexed hydrogels based on PEG-(PLA)8 have higher storage moduli compared to those based on PEG-(PLA)2. Stereocomplexed hydrogels prepared from 13 wt% PEG-(PLA)2 solutions in PBS showed a storage modulus of 0.9 kPa at 37 °C, while at similar conditions stereocomplexed hydrogels of PEG-(PLA)8 showed a storage modulus of 1.9 kPa at 10 wt%.

Original language	Undefined
Pages (from-to)	119-132
Journal	Macromolecular symposia
Volume	224
Issue number	1
DOIs	https://doi.org/10.1002/masy.200550611
Publication status	Published - 1 Apr 2005

Keywords

METIS-224367
stereocomplexation
hydrogels
poly(ethylene glycol)-poly(lactide)
Gelation
Biodegradable
Block copolymers
IR-72042

Access to Document

10.1002/masy.200550611

Cite this

Hiemstra, C., Zhong, Z., Dijkstra, P. J., & Feijen, J. (2005). Stereocomplex mediated gelation of PEG-(PLA)2 and PEG(PLA)8 block copolymers. Macromolecular symposia, 224(1), 119-132. https://doi.org/10.1002/masy.200550611

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abstract = "Stereocomplex mediated hydrogels have been prepared by mixing solutions of polymers of opposite chirality of either PEG-(PLA)2 triblock copolymers or PEG-(PLA)8 star block copolymers. The critical gel concentrations of the mixed enantiomer solutions were considerably lower compared to polymer solutions containing only the single enantiomer. Moreover, gel-sol transition temperatures were increased and gel regions were expanded due to stereocomplexation. Rheology measurements showed that stereocomplexed hydrogels based on PEG-(PLA)8 have higher storage moduli compared to those based on PEG-(PLA)2. Stereocomplexed hydrogels prepared from 13 wt{\%} PEG-(PLA)2 solutions in PBS showed a storage modulus of 0.9 kPa at 37 °C, while at similar conditions stereocomplexed hydrogels of PEG-(PLA)8 showed a storage modulus of 1.9 kPa at 10 wt{\%}.",

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author = "C. Hiemstra and Zhiyuan Zhong and Dijkstra, {Pieter J.} and Jan Feijen",

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AU - Hiemstra, C.

AU - Zhong, Zhiyuan

AU - Dijkstra, Pieter J.

AU - Feijen, Jan

N1 - Special Issue: Bio-Based Polymers: Recent Progress

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Stereocomplex mediated hydrogels have been prepared by mixing solutions of polymers of opposite chirality of either PEG-(PLA)2 triblock copolymers or PEG-(PLA)8 star block copolymers. The critical gel concentrations of the mixed enantiomer solutions were considerably lower compared to polymer solutions containing only the single enantiomer. Moreover, gel-sol transition temperatures were increased and gel regions were expanded due to stereocomplexation. Rheology measurements showed that stereocomplexed hydrogels based on PEG-(PLA)8 have higher storage moduli compared to those based on PEG-(PLA)2. Stereocomplexed hydrogels prepared from 13 wt% PEG-(PLA)2 solutions in PBS showed a storage modulus of 0.9 kPa at 37 °C, while at similar conditions stereocomplexed hydrogels of PEG-(PLA)8 showed a storage modulus of 1.9 kPa at 10 wt%.

AB - Stereocomplex mediated hydrogels have been prepared by mixing solutions of polymers of opposite chirality of either PEG-(PLA)2 triblock copolymers or PEG-(PLA)8 star block copolymers. The critical gel concentrations of the mixed enantiomer solutions were considerably lower compared to polymer solutions containing only the single enantiomer. Moreover, gel-sol transition temperatures were increased and gel regions were expanded due to stereocomplexation. Rheology measurements showed that stereocomplexed hydrogels based on PEG-(PLA)8 have higher storage moduli compared to those based on PEG-(PLA)2. Stereocomplexed hydrogels prepared from 13 wt% PEG-(PLA)2 solutions in PBS showed a storage modulus of 0.9 kPa at 37 °C, while at similar conditions stereocomplexed hydrogels of PEG-(PLA)8 showed a storage modulus of 1.9 kPa at 10 wt%.

KW - METIS-224367

KW - stereocomplexation

KW - hydrogels

KW - poly(ethylene glycol)-poly(lactide)

KW - Gelation

KW - Biodegradable

KW - Block copolymers

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