Stereocomplex mediated hydrogels have been prepared by mixing solutions of polymers of opposite chirality of either PEG-(PLA)2 triblock copolymers or PEG-(PLA)8 star block copolymers. The critical gel concentrations of the mixed enantiomer solutions were considerably lower compared to polymer solutions containing only the single enantiomer. Moreover, gel-sol transition temperatures were increased and gel regions were expanded due to stereocomplexation. Rheology measurements showed that stereocomplexed hydrogels based on PEG-(PLA)8 have higher storage moduli compared to those based on PEG-(PLA)2. Stereocomplexed hydrogels prepared from 13 wt% PEG-(PLA)2 solutions in PBS showed a storage modulus of 0.9 kPa at 37 °C, while at similar conditions stereocomplexed hydrogels of PEG-(PLA)8 showed a storage modulus of 1.9 kPa at 10 wt%.
- poly(ethylene glycol)-poly(lactide)
- Block copolymers
Hiemstra, C., Zhong, Z., Dijkstra, P. J., & Feijen, J. (2005). Stereocomplex mediated gelation of PEG-(PLA)2 and PEG(PLA)8 block copolymers. Macromolecular symposia, 224(1), 119-132. https://doi.org/10.1002/masy.200550611