Stereocomplex mediated gelation of PEG-(PLA)2 and PEG(PLA)8 block copolymers

C. Hiemstra, Zhiyuan Zhong, Pieter J. Dijkstra, Jan Feijen

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Abstract

Stereocomplex mediated hydrogels have been prepared by mixing solutions of polymers of opposite chirality of either PEG-(PLA)2 triblock copolymers or PEG-(PLA)8 star block copolymers. The critical gel concentrations of the mixed enantiomer solutions were considerably lower compared to polymer solutions containing only the single enantiomer. Moreover, gel-sol transition temperatures were increased and gel regions were expanded due to stereocomplexation. Rheology measurements showed that stereocomplexed hydrogels based on PEG-(PLA)8 have higher storage moduli compared to those based on PEG-(PLA)2. Stereocomplexed hydrogels prepared from 13 wt% PEG-(PLA)2 solutions in PBS showed a storage modulus of 0.9 kPa at 37 °C, while at similar conditions stereocomplexed hydrogels of PEG-(PLA)8 showed a storage modulus of 1.9 kPa at 10 wt%.
Original languageUndefined
Pages (from-to)119-132
JournalMacromolecular symposia
Volume224
Issue number1
DOIs
Publication statusPublished - 1 Apr 2005

Keywords

  • METIS-224367
  • stereocomplexation
  • hydrogels
  • poly(ethylene glycol)-poly(lactide)
  • Gelation
  • Biodegradable
  • Block copolymers
  • IR-72042

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