Stereocomplex mediated gelation of PEG-(PLA)2 and PEG(PLA)8 block copolymers

C. Hiemstra; Zhiyuan Zhong; Pieter J. Dijkstra; Jan Feijen

doi:10.1002/masy.200550611

Stereocomplex mediated gelation of PEG-(PLA)2 and PEG(PLA)8 block copolymers

C. Hiemstra, Zhiyuan Zhong, Pieter J. Dijkstra, Jan Feijen

Research output: Contribution to journal › Article › Academic › peer-review

66 Citations (Scopus)

Abstract

Stereocomplex mediated hydrogels have been prepared by mixing solutions of polymers of opposite chirality of either PEG-(PLA)2 triblock copolymers or PEG-(PLA)8 star block copolymers. The critical gel concentrations of the mixed enantiomer solutions were considerably lower compared to polymer solutions containing only the single enantiomer. Moreover, gel-sol transition temperatures were increased and gel regions were expanded due to stereocomplexation. Rheology measurements showed that stereocomplexed hydrogels based on PEG-(PLA)8 have higher storage moduli compared to those based on PEG-(PLA)2. Stereocomplexed hydrogels prepared from 13 wt% PEG-(PLA)2 solutions in PBS showed a storage modulus of 0.9 kPa at 37 °C, while at similar conditions stereocomplexed hydrogels of PEG-(PLA)8 showed a storage modulus of 1.9 kPa at 10 wt%.

Original language	Undefined
Pages (from-to)	119-132
Journal	Macromolecular symposia
Volume	224
Issue number	1
DOIs	https://doi.org/10.1002/masy.200550611
Publication status	Published - 1 Apr 2005

Keywords

METIS-224367
stereocomplexation
hydrogels
poly(ethylene glycol)-poly(lactide)
Gelation
Biodegradable
Block copolymers
IR-72042

Access to Document

10.1002/masy.200550611

Cite this

@article{a28924c862db429a8e6d66ba876419d2,

title = "Stereocomplex mediated gelation of PEG-(PLA)2 and PEG(PLA)8 block copolymers",

abstract = "Stereocomplex mediated hydrogels have been prepared by mixing solutions of polymers of opposite chirality of either PEG-(PLA)2 triblock copolymers or PEG-(PLA)8 star block copolymers. The critical gel concentrations of the mixed enantiomer solutions were considerably lower compared to polymer solutions containing only the single enantiomer. Moreover, gel-sol transition temperatures were increased and gel regions were expanded due to stereocomplexation. Rheology measurements showed that stereocomplexed hydrogels based on PEG-(PLA)8 have higher storage moduli compared to those based on PEG-(PLA)2. Stereocomplexed hydrogels prepared from 13 wt% PEG-(PLA)2 solutions in PBS showed a storage modulus of 0.9 kPa at 37 °C, while at similar conditions stereocomplexed hydrogels of PEG-(PLA)8 showed a storage modulus of 1.9 kPa at 10 wt%.",

keywords = "METIS-224367, stereocomplexation, hydrogels, poly(ethylene glycol)-poly(lactide), Gelation, Biodegradable, Block copolymers, IR-72042",

author = "C. Hiemstra and Zhiyuan Zhong and Dijkstra, {Pieter J.} and Jan Feijen",

note = "Special Issue: Bio-Based Polymers: Recent Progress ",

year = "2005",

month = apr,

day = "1",

doi = "10.1002/masy.200550611",

language = "Undefined",

volume = "224",

pages = "119--132",

journal = "Macromolecular symposia",

issn = "1022-1360",

publisher = "Wiley-VCH Verlag",

number = "1",

}

TY - JOUR

T1 - Stereocomplex mediated gelation of PEG-(PLA)2 and PEG(PLA)8 block copolymers

AU - Hiemstra, C.

AU - Zhong, Zhiyuan

AU - Dijkstra, Pieter J.

AU - Feijen, Jan

N1 - Special Issue: Bio-Based Polymers: Recent Progress

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Stereocomplex mediated hydrogels have been prepared by mixing solutions of polymers of opposite chirality of either PEG-(PLA)2 triblock copolymers or PEG-(PLA)8 star block copolymers. The critical gel concentrations of the mixed enantiomer solutions were considerably lower compared to polymer solutions containing only the single enantiomer. Moreover, gel-sol transition temperatures were increased and gel regions were expanded due to stereocomplexation. Rheology measurements showed that stereocomplexed hydrogels based on PEG-(PLA)8 have higher storage moduli compared to those based on PEG-(PLA)2. Stereocomplexed hydrogels prepared from 13 wt% PEG-(PLA)2 solutions in PBS showed a storage modulus of 0.9 kPa at 37 °C, while at similar conditions stereocomplexed hydrogels of PEG-(PLA)8 showed a storage modulus of 1.9 kPa at 10 wt%.

AB - Stereocomplex mediated hydrogels have been prepared by mixing solutions of polymers of opposite chirality of either PEG-(PLA)2 triblock copolymers or PEG-(PLA)8 star block copolymers. The critical gel concentrations of the mixed enantiomer solutions were considerably lower compared to polymer solutions containing only the single enantiomer. Moreover, gel-sol transition temperatures were increased and gel regions were expanded due to stereocomplexation. Rheology measurements showed that stereocomplexed hydrogels based on PEG-(PLA)8 have higher storage moduli compared to those based on PEG-(PLA)2. Stereocomplexed hydrogels prepared from 13 wt% PEG-(PLA)2 solutions in PBS showed a storage modulus of 0.9 kPa at 37 °C, while at similar conditions stereocomplexed hydrogels of PEG-(PLA)8 showed a storage modulus of 1.9 kPa at 10 wt%.

KW - METIS-224367

KW - stereocomplexation

KW - hydrogels

KW - poly(ethylene glycol)-poly(lactide)

KW - Gelation

KW - Biodegradable

KW - Block copolymers

KW - IR-72042

U2 - 10.1002/masy.200550611

DO - 10.1002/masy.200550611

M3 - Article

VL - 224

SP - 119

EP - 132

JO - Macromolecular symposia

JF - Macromolecular symposia

SN - 1022-1360

IS - 1

ER -