Abstract
Stereocomplex mediated hydrogels have been prepared by mixing solutions of polymers of opposite chirality of either PEG-(PLA)2 triblock copolymers or PEG-(PLA)8 star block copolymers. The critical gel concentrations of the mixed enantiomer solutions were considerably lower compared to polymer solutions containing only the single enantiomer. Moreover, gel-sol transition temperatures were increased and gel regions were expanded due to stereocomplexation. Rheology measurements showed that stereocomplexed hydrogels based on PEG-(PLA)8 have higher storage moduli compared to those based on PEG-(PLA)2. Stereocomplexed hydrogels prepared from 13 wt% PEG-(PLA)2 solutions in PBS showed a storage modulus of 0.9 kPa at 37 °C, while at similar conditions stereocomplexed hydrogels of PEG-(PLA)8 showed a storage modulus of 1.9 kPa at 10 wt%.
Original language | Undefined |
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Pages (from-to) | 119-132 |
Journal | Macromolecular symposia |
Volume | 224 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Apr 2005 |
Keywords
- METIS-224367
- stereocomplexation
- hydrogels
- poly(ethylene glycol)-poly(lactide)
- Gelation
- Biodegradable
- Block copolymers
- IR-72042