Stimuli-responsive soft untethered grippers for drug delivery and robotic surgery

Arijit Ghosh, ChangKyu Yoon, F. Ongaro, Stefano Scheggi, Florin M Selaru, Sarthak Misra, David H. Gracias

    Research output: Contribution to journalReview articleAcademicpeer-review

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    Abstract

    Untethered microtools that can be precisely navigated into deep in vivo locations are important for clinical procedures pertinent to minimally invasive surgery and targeted drug delivery. In this mini-review, untethered soft grippers are discussed, with an emphasis on a class of autonomous stimuli-responsive gripping soft tools that can be used to excise tissues and release drugs in a controlled manner. The grippers are composed of polymers and hydrogels and are thus compliant to soft tissues. They can be navigated using magnetic fields and controlled by robotic path-planning strategies to carry out tasks like pick-and-place of microspheres and biological materials either with user assistance, or in a fully autonomous manner. It is envisioned that the use of these untethered soft grippers will translate from laboratory experiments to clinical scenarios and the challenges that need to be overcome to make this transition are discussed.
    Original languageEnglish
    Article number7
    JournalFrontiers in Mechanical Engineering
    Volume3
    DOIs
    Publication statusPublished - 26 Jul 2017

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    Robotics
    Hydrogels
    Minimally Invasive Surgical Procedures
    Magnetic Fields
    Microspheres
    Pharmaceutical Preparations
    Polymers
    Drug Liberation

    Cite this

    Ghosh, Arijit ; Yoon, ChangKyu ; Ongaro, F. ; Scheggi, Stefano ; Selaru, Florin M ; Misra, Sarthak ; Gracias, David H. / Stimuli-responsive soft untethered grippers for drug delivery and robotic surgery. In: Frontiers in Mechanical Engineering. 2017 ; Vol. 3.
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    abstract = "Untethered microtools that can be precisely navigated into deep in vivo locations are important for clinical procedures pertinent to minimally invasive surgery and targeted drug delivery. In this mini-review, untethered soft grippers are discussed, with an emphasis on a class of autonomous stimuli-responsive gripping soft tools that can be used to excise tissues and release drugs in a controlled manner. The grippers are composed of polymers and hydrogels and are thus compliant to soft tissues. They can be navigated using magnetic fields and controlled by robotic path-planning strategies to carry out tasks like pick-and-place of microspheres and biological materials either with user assistance, or in a fully autonomous manner. It is envisioned that the use of these untethered soft grippers will translate from laboratory experiments to clinical scenarios and the challenges that need to be overcome to make this transition are discussed.",
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    Stimuli-responsive soft untethered grippers for drug delivery and robotic surgery. / Ghosh, Arijit; Yoon, ChangKyu; Ongaro, F.; Scheggi, Stefano; Selaru, Florin M; Misra, Sarthak; Gracias, David H.

    In: Frontiers in Mechanical Engineering, Vol. 3, 7, 26.07.2017.

    Research output: Contribution to journalReview articleAcademicpeer-review

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    AU - Ghosh, Arijit

    AU - Yoon, ChangKyu

    AU - Ongaro, F.

    AU - Scheggi, Stefano

    AU - Selaru, Florin M

    AU - Misra, Sarthak

    AU - Gracias, David H.

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    AB - Untethered microtools that can be precisely navigated into deep in vivo locations are important for clinical procedures pertinent to minimally invasive surgery and targeted drug delivery. In this mini-review, untethered soft grippers are discussed, with an emphasis on a class of autonomous stimuli-responsive gripping soft tools that can be used to excise tissues and release drugs in a controlled manner. The grippers are composed of polymers and hydrogels and are thus compliant to soft tissues. They can be navigated using magnetic fields and controlled by robotic path-planning strategies to carry out tasks like pick-and-place of microspheres and biological materials either with user assistance, or in a fully autonomous manner. It is envisioned that the use of these untethered soft grippers will translate from laboratory experiments to clinical scenarios and the challenges that need to be overcome to make this transition are discussed.

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