Strategies for Zonal Cartilage Repair using Hydrogels

Travis J. Klein, Simone C. Rizzi, Johannes C. Reichert, Nicole Georgi, Jos Malda, Wouter Schuurman, Ross W. Crawford, Dietmar W. Hutmacher

Research output: Contribution to journalArticleAcademic

106 Citations (Scopus)

Abstract

Articular cartilage is a highly hydrated tissue with depth-dependent cellular and matrix properties that provide low-friction load bearing in joints. However, the structure and function are frequently lost and there is insufficient repair response to regenerate high-quality cartilage. Several hydrogel-based tissue-engineering strategies have recently been developed to form constructs with biomimetic zonal variations to improve cartilage repair. Modular hydrogel systems allow for systematic control over hydrogel properties, and advanced fabrication techniques allow for control over construct organization. These technologies have great potential to address many unanswered questions involved in prescribing zonal properties to tissue-engineered constructs for cartilage repair.
Original languageEnglish
Pages (from-to)1049-1058
JournalMacromolecular bioscience
Volume9
Issue number11
DOIs
Publication statusPublished - 2009

Keywords

  • Cartilage
  • Hydrogels
  • Tissue engineering
  • Biological applications of polymers
  • Biomimetic

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