Stratified breast cancer follow-up using a partially observable Markov decision process

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Abstract

Frequency and duration of follow-up for patients with breast cancer is still under discussion. Current follow-up consists of annual mammography for the first five years after treatment and does not depend on the personal risk of developing a locoregional recurrence (LRR) or second primary tumor. Aim of this study is to gain insight in how to allocate resources for optimal and personal follow-up. We formulate a discrete-time Partially Observable Markov Decision Process (POMDP) with a finite horzion in which we aim to maximize the total expected number of quality-adjusted life years (QALYs). Transition probabilities were obtained from data from the Netherlands Cancer Registry (NCR). Twice a year the decision is made whether or not a mammography will be performed. Recurrent disease can be detected by both mammography or women themselves (self-detection). The optimal policies were determined for three risk categories based on differentiation of the primary tumor. Our results suggest a slightly more intensive follow-up for patients with a high risk and poorly differentiated tumor, and a less intensive schedule for the other risk groups.
Original languageEnglish
Title of host publicationMarkov Decision Processes in Practice
EditorsRichard J. Boucherie, Nico M. van Dijk
Place of PublicationCham
PublisherSpringer
Pages223-244
Number of pages22
ISBN (Electronic)978-3-319-47766-4
ISBN (Print)978-3-319-47764-0
DOIs
Publication statusPublished - Mar 2017

Publication series

NameInternational Series in Operations Research & Management Science
PublisherSpringer International Publishing
Volume248
ISSN (Print)0884-8289

Fingerprint

Markov Chains
Mammography
Breast Neoplasms
Neoplasms
Quality-Adjusted Life Years
Netherlands
Registries
Appointments and Schedules
Recurrence
Therapeutics

Keywords

  • Partially observable markov decision process
  • Breast cancer
  • Optimal policies
  • Stratified follow-up

Cite this

Otten, J. W. M., Witteveen, A., Vliegen, I. M. H., Siesling, S., Timmer, J. B., & IJzerman, M. J. (2017). Stratified breast cancer follow-up using a partially observable Markov decision process. In R. J. Boucherie, & N. M. van Dijk (Eds.), Markov Decision Processes in Practice (pp. 223-244). (International Series in Operations Research & Management Science; Vol. 248). Cham: Springer. https://doi.org/10.1007/978-3-319-47766-4_7
Otten, J.W.M. ; Witteveen, A. ; Vliegen, I.M.H. ; Siesling, S. ; Timmer, J.B. ; IJzerman, M.J. / Stratified breast cancer follow-up using a partially observable Markov decision process. Markov Decision Processes in Practice. editor / Richard J. Boucherie ; Nico M. van Dijk. Cham : Springer, 2017. pp. 223-244 (International Series in Operations Research & Management Science).
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Otten, JWM, Witteveen, A, Vliegen, IMH, Siesling, S, Timmer, JB & IJzerman, MJ 2017, Stratified breast cancer follow-up using a partially observable Markov decision process. in RJ Boucherie & NM van Dijk (eds), Markov Decision Processes in Practice. International Series in Operations Research & Management Science, vol. 248, Springer, Cham, pp. 223-244. https://doi.org/10.1007/978-3-319-47766-4_7

Stratified breast cancer follow-up using a partially observable Markov decision process. / Otten, J.W.M.; Witteveen, A.; Vliegen, I.M.H.; Siesling, S.; Timmer, J.B.; IJzerman, M.J.

Markov Decision Processes in Practice. ed. / Richard J. Boucherie; Nico M. van Dijk. Cham : Springer, 2017. p. 223-244 (International Series in Operations Research & Management Science; Vol. 248).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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Otten JWM, Witteveen A, Vliegen IMH, Siesling S, Timmer JB, IJzerman MJ. Stratified breast cancer follow-up using a partially observable Markov decision process. In Boucherie RJ, van Dijk NM, editors, Markov Decision Processes in Practice. Cham: Springer. 2017. p. 223-244. (International Series in Operations Research & Management Science). https://doi.org/10.1007/978-3-319-47766-4_7