Structural substrates for resting network disruption in temporal lobe epilepsy

N.L. Voets, Christian Beckmann, D.M. Cole, S. Hong, A. Bernasconi, N. Bernasconi

Research output: Contribution to journalArticleAcademicpeer-review

90 Citations (Scopus)

Abstract

Magnetic resonance imaging methods that measure interregional brain signalling at rest have been advanced as powerful tools to probe organizational properties of functional networks. In drug-resistant temporal lobe epilepsy, resting functional magnetic resonance imaging studies have primarily employed region of interest approaches that preclude a comprehensive evaluation of large-scale functional interactions. In line with the distributed nature of structural damage in this condition, we set out to quantify connectivity across the entire range of resting networks. Furthermore, we assessed whether connectivity is driven by co-localized structural pathology. We obtained resting state, diffusion tensor and anatomical imaging data in 35 patients with temporal lobe epilepsy and 20 healthy subjects on a 3 T scanner. Resting state networks were identified using independent component analysis, which allows an objective whole-brain quantification of functional connectivity. We performed group comparisons before and after correcting for voxel-wise grey matter density. In addition, we identified voxel-wise associations between resting connectivity and white matter coherence indexed by fractional anisotropy. Compared with controls, patients showed altered (typically reduced) functional connectivity between the hippocampus, anterior temporal, precentral cortices and the default mode and sensorimotor networks. Reduced network integration of the hippocampus was explained by variations in grey matter density, while functional connectivity of the parahippocampus, and frontal and temporal neocortices showed atypical associations with white matter coherence within pathways carrying connections of these regions. Our multimodal imaging study suggests that in temporal lobe epilepsy, cortical atrophy and microstructural white matter damage impact functional resting connectivity
Original languageEnglish
Pages (from-to)2350-2357
JournalBrain
Volume135
Issue number8
DOIs
Publication statusPublished - 2012

Fingerprint

Temporal Lobe Epilepsy
Hippocampus
Multimodal Imaging
Magnetic Resonance Imaging
Diffusion Tensor Imaging
Neocortex
Anisotropy
Brain
Temporal Lobe
Atrophy
Healthy Volunteers
Pathology
White Matter
Gray Matter

Keywords

  • METIS-292334
  • IR-83012

Cite this

Voets, N. L., Beckmann, C., Cole, D. M., Hong, S., Bernasconi, A., & Bernasconi, N. (2012). Structural substrates for resting network disruption in temporal lobe epilepsy. Brain, 135(8), 2350-2357. https://doi.org/10.1093/brain/aws137
Voets, N.L. ; Beckmann, Christian ; Cole, D.M. ; Hong, S. ; Bernasconi, A. ; Bernasconi, N. / Structural substrates for resting network disruption in temporal lobe epilepsy. In: Brain. 2012 ; Vol. 135, No. 8. pp. 2350-2357.
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Voets, NL, Beckmann, C, Cole, DM, Hong, S, Bernasconi, A & Bernasconi, N 2012, 'Structural substrates for resting network disruption in temporal lobe epilepsy' Brain, vol. 135, no. 8, pp. 2350-2357. https://doi.org/10.1093/brain/aws137

Structural substrates for resting network disruption in temporal lobe epilepsy. / Voets, N.L.; Beckmann, Christian; Cole, D.M.; Hong, S.; Bernasconi, A.; Bernasconi, N.

In: Brain, Vol. 135, No. 8, 2012, p. 2350-2357.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Structural substrates for resting network disruption in temporal lobe epilepsy

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Voets NL, Beckmann C, Cole DM, Hong S, Bernasconi A, Bernasconi N. Structural substrates for resting network disruption in temporal lobe epilepsy. Brain. 2012;135(8):2350-2357. https://doi.org/10.1093/brain/aws137