Structure formation and hydrogen bonding in all-aliphatic segmented copolymers with uniform hard segments

Ya I. Odarchenko, N. J. Sijbrandi, M. Rosenthal, A. J. Kimenai, E. P.C. Mes, R. Broos, G. Bar, P. J. Dijkstra, J. Feijen, D. A. Ivanov*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    12 Citations (Scopus)

    Abstract

    Fully aliphatic segmented poly(ether ester amide) copolymers with uniform hard segments prepared by melt polycondensation of α,ω-hydroxyl end-functionalized polytetrahydrofuran and short glycine or β-alanine bisester-bisoxalamide units hold promise for biomedical applications. For polymers with the hard block contents varying from 10% to 27%, differential scanning calorimetry and atomic force microscopy reveal a highly phase-separated morphology, with ribbon-like nanocrystals dispersed in the soft segment matrix. To relate the polymer properties to the structure of the hard segment, the monomers were prepared and studied by optical and X-ray diffraction measurements. It was shown that the glycine and β-alanine carbonyl ester groups are tilted away from the oxalamide plane, which can affect the degradation rate via hydrolysis of the ester bond.

    Original languageEnglish
    Pages (from-to)6143-6149
    Number of pages7
    JournalActa biomaterialia
    Volume9
    Issue number4
    DOIs
    Publication statusPublished - Apr 2013

    Keywords

    • Bisester-bisoxalamide
    • Hydrogen bonding
    • Segmented poly(ether ester amide)s
    • Thermoplastic elastomers
    • X-ray scattering

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