STUDIES ON NORETHINDRONE COVALENTLY BONDED TO POLY-N**5(3-HYDROXYPROPYL)-L-GLUTAMINE.

R. v. Petersen*, J. M. Anderson, S. M. Fang, J. Feijen, D. E. Gregonis, S. W. Kim

*Corresponding author for this work

    Research output: Contribution to conferencePaper

    7 Citations (Scopus)

    Abstract

    This paper is concerned with the subject of sustained release of drugs from polymeric matrices. Until now only a few examples are available where steroids are covalently bonded to a polymeric system and no data are available about the coupling of steroids to biodegradable polymers. In this paper the authors report a new derivatization of 17 alpha -ethynyl-17 beta -hydroxy steroids which report applicable for attachment to biodegradable poly( alpha -amino acids). The reports covers the following topics - syntheses; in-vivo pharmacokinetic study; in-vitro lability study of carbonate bond between NE and the Spacer Group; in-vitro hydrolysis of compounds VI and VII; in vitro release of drug from compound VIII; immunologic and biocompatibility studies.

    Original languageEnglish
    Pages20-23 ACPPAY
    Publication statusPublished - 1 Sep 1979
    EventSymposium on Polypeptides and Proteins 1979 - Washington, United States
    Duration: 10 Sep 197914 Sep 1979

    Conference

    ConferenceSymposium on Polypeptides and Proteins 1979
    CountryUnited States
    CityWashington
    Period10/09/7914/09/79

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    Cite this

    Petersen, R. V., Anderson, J. M., Fang, S. M., Feijen, J., Gregonis, D. E., & Kim, S. W. (1979). STUDIES ON NORETHINDRONE COVALENTLY BONDED TO POLY-N**5(3-HYDROXYPROPYL)-L-GLUTAMINE.. 20-23 ACPPAY. Paper presented at Symposium on Polypeptides and Proteins 1979, Washington, United States.