This paper is concerned with the subject of sustained release of drugs from polymeric matrices. Until now only a few examples are available where steroids are covalently bonded to a polymeric system and no data are available about the coupling of steroids to biodegradable polymers. In this paper the authors report a new derivatization of 17 alpha -ethynyl-17 beta -hydroxy steroids which report applicable for attachment to biodegradable poly( alpha -amino acids). The reports covers the following topics - syntheses; in-vivo pharmacokinetic study; in-vitro lability study of carbonate bond between NE and the Spacer Group; in-vitro hydrolysis of compounds VI and VII; in vitro release of drug from compound VIII; immunologic and biocompatibility studies.
|Publication status||Published - 1 Sep 1979|
|Event||Symposium on Polypeptides and Proteins 1979 - Washington, United States|
Duration: 10 Sep 1979 → 14 Sep 1979
|Conference||Symposium on Polypeptides and Proteins 1979|
|Period||10/09/79 → 14/09/79|