STUDIES ON NORETHINDRONE COVALENTLY BONDED TO POLY-N**5(3-HYDROXYPROPYL)-L-GLUTAMINE.

R. v. Petersen; J. M. Anderson; S. M. Fang; J. Feijen; D. E. Gregonis; S. W. Kim

STUDIES ON NORETHINDRONE COVALENTLY BONDED TO POLY-N**5(3-HYDROXYPROPYL)-L-GLUTAMINE.

R. v. Petersen^*, J. M. Anderson, S. M. Fang, J. Feijen, D. E. Gregonis, S. W. Kim

^*Corresponding author for this work

Research output: Contribution to conference › Paper › peer-review

7 Citations (Scopus)

Abstract

This paper is concerned with the subject of sustained release of drugs from polymeric matrices. Until now only a few examples are available where steroids are covalently bonded to a polymeric system and no data are available about the coupling of steroids to biodegradable polymers. In this paper the authors report a new derivatization of 17 alpha -ethynyl-17 beta -hydroxy steroids which report applicable for attachment to biodegradable poly( alpha -amino acids). The reports covers the following topics - syntheses; in-vivo pharmacokinetic study; in-vitro lability study of carbonate bond between NE and the Spacer Group; in-vitro hydrolysis of compounds VI and VII; in vitro release of drug from compound VIII; immunologic and biocompatibility studies.

Original language	English
Pages	20-23 ACPPAY
Publication status	Published - 1 Sept 1979
Event	Symposium on Polypeptides and Proteins 1979 - Washington, United States Duration: 10 Sept 1979 → 14 Sept 1979

Conference

Conference	Symposium on Polypeptides and Proteins 1979
Country/Territory	United States
City	Washington
Period	10/09/79 → 14/09/79

Cite this

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title = "STUDIES ON NORETHINDRONE COVALENTLY BONDED TO POLY-N**5(3-HYDROXYPROPYL)-L-GLUTAMINE.",

abstract = "This paper is concerned with the subject of sustained release of drugs from polymeric matrices. Until now only a few examples are available where steroids are covalently bonded to a polymeric system and no data are available about the coupling of steroids to biodegradable polymers. In this paper the authors report a new derivatization of 17 alpha -ethynyl-17 beta -hydroxy steroids which report applicable for attachment to biodegradable poly( alpha -amino acids). The reports covers the following topics - syntheses; in-vivo pharmacokinetic study; in-vitro lability study of carbonate bond between NE and the Spacer Group; in-vitro hydrolysis of compounds VI and VII; in vitro release of drug from compound VIII; immunologic and biocompatibility studies.",

author = "Petersen, {R. v.} and Anderson, {J. M.} and Fang, {S. M.} and J. Feijen and Gregonis, {D. E.} and Kim, {S. W.}",

year = "1979",

month = sep,

day = "1",

language = "English",

pages = "20--23 ACPPAY",

note = "Symposium on Polypeptides and Proteins 1979 ; Conference date: 10-09-1979 Through 14-09-1979",

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T1 - STUDIES ON NORETHINDRONE COVALENTLY BONDED TO POLY-N**5(3-HYDROXYPROPYL)-L-GLUTAMINE.

AU - Petersen, R. v.

AU - Anderson, J. M.

AU - Fang, S. M.

AU - Feijen, J.

AU - Gregonis, D. E.

AU - Kim, S. W.

PY - 1979/9/1

Y1 - 1979/9/1

N2 - This paper is concerned with the subject of sustained release of drugs from polymeric matrices. Until now only a few examples are available where steroids are covalently bonded to a polymeric system and no data are available about the coupling of steroids to biodegradable polymers. In this paper the authors report a new derivatization of 17 alpha -ethynyl-17 beta -hydroxy steroids which report applicable for attachment to biodegradable poly( alpha -amino acids). The reports covers the following topics - syntheses; in-vivo pharmacokinetic study; in-vitro lability study of carbonate bond between NE and the Spacer Group; in-vitro hydrolysis of compounds VI and VII; in vitro release of drug from compound VIII; immunologic and biocompatibility studies.

AB - This paper is concerned with the subject of sustained release of drugs from polymeric matrices. Until now only a few examples are available where steroids are covalently bonded to a polymeric system and no data are available about the coupling of steroids to biodegradable polymers. In this paper the authors report a new derivatization of 17 alpha -ethynyl-17 beta -hydroxy steroids which report applicable for attachment to biodegradable poly( alpha -amino acids). The reports covers the following topics - syntheses; in-vivo pharmacokinetic study; in-vitro lability study of carbonate bond between NE and the Spacer Group; in-vitro hydrolysis of compounds VI and VII; in vitro release of drug from compound VIII; immunologic and biocompatibility studies.

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M3 - Paper

AN - SCOPUS:0018521734

SP - 20-23 ACPPAY

T2 - Symposium on Polypeptides and Proteins 1979

Y2 - 10 September 1979 through 14 September 1979

ER -

STUDIES ON NORETHINDRONE COVALENTLY BONDED TO POLY-N**5(3-HYDROXYPROPYL)-L-GLUTAMINE.

Abstract

Conference

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