Abstract
The consolidation and compaction behaviour of sieve fractions of crystalline α-lactose monohydrate were studied. From mercury porosimetry measurements tablet pore surface areas were derived. At a certain compaction load it appeared that tablets compressed from small particles were generally stronger and showed a larger surface area than compacts prepared from coarse sieve fractions. By plotting compact strength against pore surface area, a unique linear relationship was obtained. From these results it can be concluded that the actual tablet surface area, being a function of both the initial particle size and applied compaction pressure, is responsible for the compact strength.
Original language | Undefined |
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Pages (from-to) | 145-150 |
Journal | Pharmaceutisch weekblad |
Volume | 8 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1986 |
Keywords
- Fragmentation
- Lactose
- Particle size
- Porosity
- Compaction
- Consolidation
- IR-85802
- Crushing strength
- Tablets