Studies on tableting properties of lactose. Part III. The consolidation behaviour of sieve fractions of crystalline a-lactose monohydrate

A.H. de Boer, H. Vromans, C.F. Lerk, G.K. Bolhuis, K.D. Kussendrager, H. Bosch

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Abstract

The consolidation and compaction behaviour of sieve fractions of crystalline α-lactose monohydrate were studied. From mercury porosimetry measurements tablet pore surface areas were derived. At a certain compaction load it appeared that tablets compressed from small particles were generally stronger and showed a larger surface area than compacts prepared from coarse sieve fractions. By plotting compact strength against pore surface area, a unique linear relationship was obtained. From these results it can be concluded that the actual tablet surface area, being a function of both the initial particle size and applied compaction pressure, is responsible for the compact strength.
Original languageUndefined
Pages (from-to)145-150
JournalPharmaceutisch weekblad
Volume8
Issue number2
DOIs
Publication statusPublished - 1986

Keywords

  • Fragmentation
  • Lactose
  • Particle size
  • Porosity
  • Compaction
  • Consolidation
  • IR-85802
  • Crushing strength
  • Tablets

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