Study of the geometry in a 3D flow-focusing device

Elena Castro-Hernandez, Maarten Kok, Michel Versluis, David Fernandez Rivas

  • 2 Citations

Abstract

We present a numerical and experimental study on a non-planar three-dimensional design of a microfluidic flow-focusing device for the well-controlled generation of monodisperse micron-sized droplets. Three relevant geometric parameters were identified: the distance between the inner inlet channel and the outlet channel, the width of the outlet channel, and its length. Simulation data extracted from a full parameter study and finite element simulations yielded four optimum designs that were then fabricated using soft lithography techniques. Under the predicted operating conditions, micro-droplets of a size of ∼1μm in diameter are obtained from a channel 50μm in width. This work represents an important breakthrough in the practical use of flow-focusing devices delivering a ratio of constriction to droplet size of 50 times, with the advantage of reduced clogging of the micro-channel, greatly improving the control and reliability of the device.
Original languageEnglish
Article number40
Pages (from-to)40-
JournalMicrofluidics and nanofluidics
Volume20
Issue number40
DOIs
StatePublished - 2 Feb 2016

Fingerprint

Microfluidics
Lithography
Geometry

Keywords

  • METIS-315445
  • IR-99198

Cite this

Castro-Hernandez, Elena; Kok, Maarten; Versluis, Michel; Fernandez Rivas, David / Study of the geometry in a 3D flow-focusing device.

In: Microfluidics and nanofluidics, Vol. 20, No. 40, 40, 02.02.2016, p. 40-.

Research output: Scientific - peer-reviewArticle

@article{99d6c04a48b64fb4ab0f7cc0a6ff3cb8,
title = "Study of the geometry in a 3D flow-focusing device",
abstract = "We present a numerical and experimental study on a non-planar three-dimensional design of a microfluidic flow-focusing device for the well-controlled generation of monodisperse micron-sized droplets. Three relevant geometric parameters were identified: the distance between the inner inlet channel and the outlet channel, the width of the outlet channel, and its length. Simulation data extracted from a full parameter study and finite element simulations yielded four optimum designs that were then fabricated using soft lithography techniques. Under the predicted operating conditions, micro-droplets of a size of ∼1μm in diameter are obtained from a channel 50μm in width. This work represents an important breakthrough in the practical use of flow-focusing devices delivering a ratio of constriction to droplet size of 50 times, with the advantage of reduced clogging of the micro-channel, greatly improving the control and reliability of the device.",
keywords = "METIS-315445, IR-99198",
author = "Elena Castro-Hernandez and Maarten Kok and Michel Versluis and {Fernandez Rivas}, David",
year = "2016",
month = "2",
doi = "10.1007/s10404-016-1708-3",
volume = "20",
pages = "40--",
journal = "Microfluidics and nanofluidics",
issn = "1613-4982",
publisher = "Springer Verlag",
number = "40",

}

Study of the geometry in a 3D flow-focusing device. / Castro-Hernandez, Elena; Kok, Maarten; Versluis, Michel; Fernandez Rivas, David.

In: Microfluidics and nanofluidics, Vol. 20, No. 40, 40, 02.02.2016, p. 40-.

Research output: Scientific - peer-reviewArticle

TY - JOUR

T1 - Study of the geometry in a 3D flow-focusing device

AU - Castro-Hernandez,Elena

AU - Kok,Maarten

AU - Versluis,Michel

AU - Fernandez Rivas,David

PY - 2016/2/2

Y1 - 2016/2/2

N2 - We present a numerical and experimental study on a non-planar three-dimensional design of a microfluidic flow-focusing device for the well-controlled generation of monodisperse micron-sized droplets. Three relevant geometric parameters were identified: the distance between the inner inlet channel and the outlet channel, the width of the outlet channel, and its length. Simulation data extracted from a full parameter study and finite element simulations yielded four optimum designs that were then fabricated using soft lithography techniques. Under the predicted operating conditions, micro-droplets of a size of ∼1μm in diameter are obtained from a channel 50μm in width. This work represents an important breakthrough in the practical use of flow-focusing devices delivering a ratio of constriction to droplet size of 50 times, with the advantage of reduced clogging of the micro-channel, greatly improving the control and reliability of the device.

AB - We present a numerical and experimental study on a non-planar three-dimensional design of a microfluidic flow-focusing device for the well-controlled generation of monodisperse micron-sized droplets. Three relevant geometric parameters were identified: the distance between the inner inlet channel and the outlet channel, the width of the outlet channel, and its length. Simulation data extracted from a full parameter study and finite element simulations yielded four optimum designs that were then fabricated using soft lithography techniques. Under the predicted operating conditions, micro-droplets of a size of ∼1μm in diameter are obtained from a channel 50μm in width. This work represents an important breakthrough in the practical use of flow-focusing devices delivering a ratio of constriction to droplet size of 50 times, with the advantage of reduced clogging of the micro-channel, greatly improving the control and reliability of the device.

KW - METIS-315445

KW - IR-99198

U2 - 10.1007/s10404-016-1708-3

DO - 10.1007/s10404-016-1708-3

M3 - Article

VL - 20

SP - 40-

JO - Microfluidics and nanofluidics

T2 - Microfluidics and nanofluidics

JF - Microfluidics and nanofluidics

SN - 1613-4982

IS - 40

M1 - 40

ER -