Studying Nanoparticle Penetration in 3D Multicellular Tumour Models On-Chip

Jean-Baptiste Blondé, Dwi Priwitaningrum, Jai Prakash, Séverine le Gac

Research output: Contribution to conferencePoster

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Abstract

Here, we report a breast tumour-on-a-chip platform to evaluate the penetration of nanomedicines in 3D tumour spheroids, as a function of the tumour spheroid cellular composition. Mouse multicellular tumour mono-culture spheroids and cancer cell-fibroblast co-culture spheroids were exposed to silica nanoparticles (NPs) (30 or 100nm) or liposomes (100nm) at various flowrates, mimicking the shear stress levels found in vivo. Results revealed that the NP penetration was influenced by the shear stress, and that the presence of fibroblasts in the tumour spheroids greatly reduced the penetration depth of the nanoparticles.
Original languageEnglish
Publication statusPublished - Oct 2018
EventNanoBioTech Montreux 2018 - Montreux, France
Duration: 29 Oct 201831 Oct 2018

Conference

ConferenceNanoBioTech Montreux 2018
CountryFrance
CityMontreux
Period29/10/1831/10/18

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Keywords

  • Microfluidics
  • Tumour Spheroid
  • Nanomedicine

Cite this

Blondé, J-B., Priwitaningrum, D., Prakash, J., & le Gac, S. (2018). Studying Nanoparticle Penetration in 3D Multicellular Tumour Models On-Chip. Poster session presented at NanoBioTech Montreux 2018, Montreux, France.