Abstract
DNA sequencing in a lab-on-a-chip aims at providing cheap, high-speed analysis of low reagent volumes to, e.g., identify genomic deletions or insertions associated with genetic illnesses. Detecting single base-pair insertions or deletions from DNA fragments in the diagnostically relevant range of 150-1000 base-pairs requires a sizing accuracy of S < 10^-3, while only S < 10^-2 were reported. Here we demonstrate a sizing accuracy of S = 4 x 10^-4, thereby paving the way for the envisaged applications.
Original language | Undefined |
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Pages | Page 26 |
Number of pages | 1 |
Publication status | Published - Sep 2014 |
Event | 40th International Conference on Micro & Nano Engineering, MNE 2014 - Lausanne, Switzerland Duration: 22 Sep 2014 → 26 Sep 2014 Conference number: 40 |
Conference
Conference | 40th International Conference on Micro & Nano Engineering, MNE 2014 |
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Abbreviated title | MNE |
Country/Territory | Switzerland |
City | Lausanne |
Period | 22/09/14 → 26/09/14 |
Keywords
- Capillary electrophoresis
- femtosecond laser writing
- EWI-25107
- microfluidic chip
- IR-91972
- IOMS-SNS: SENSORS
- DNA separation