Subharmonic behavior of phospholipid-coated ultrasound contrast agent microbubbles

J. Sijl, B. Dollet, M.L.J. Overvelde, V. Garbin, Valeria Garbin, Timo Rozendal, N. de Jong, Detlef Lohse, Michel Versluis

Research output: Contribution to journalArticleAcademicpeer-review

72 Citations (Scopus)

Abstract

Coated microbubbles, unlike tissue are able to scatter sound subharmonically. Therefore, the subharmonic behavior of coated microbubbles can be used to enhance the contrast in ultrasound contrast imaging. Theoretically, a threshold amplitude of the driving pressure can be calculated above which subharmonic oscillations of microbubbles are initiated. Interestingly, earlier experimental studies on coated microbubbles demonstrated that the threshold for these bubbles is much lower than predicted by the traditional linear viscoelastic shell models. This paper presents an experimental study on the subharmonic behavior of differently sized individual phospholipid coated microbubbles. The radial subharmonic response of the microbubbles was recorded with the Brandaris ultra high-speed camera as a function of both the amplitude and the frequency of the driving pulse. Threshold pressures for subharmonic generation as low as 5 kPa were found near a driving frequency equal to twice the resonance frequency of the bubble. An explanation for this low threshold pressure is provided by the shell buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499–3505 (2005)] . It is shown that the change in the elasticity of the bubble shell as a function of bubble radius as proposed in this model, enhances the subharmonic behavior of the microbubbles.
Original languageUndefined
Pages (from-to)3239-3252
Number of pages14
JournalJournal of the Acoustical Society of America
Volume128
Issue number5
DOIs
Publication statusPublished - 2010

Keywords

  • lipid bilayers
  • METIS-269537
  • bioacoustics
  • Bubbles
  • IR-79274
  • ultrasonic imaging

Cite this

Sijl, J. ; Dollet, B. ; Overvelde, M.L.J. ; Garbin, V. ; Garbin, Valeria ; Rozendal, Timo ; de Jong, N. ; Lohse, Detlef ; Versluis, Michel. / Subharmonic behavior of phospholipid-coated ultrasound contrast agent microbubbles. In: Journal of the Acoustical Society of America. 2010 ; Vol. 128, No. 5. pp. 3239-3252.
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abstract = "Coated microbubbles, unlike tissue are able to scatter sound subharmonically. Therefore, the subharmonic behavior of coated microbubbles can be used to enhance the contrast in ultrasound contrast imaging. Theoretically, a threshold amplitude of the driving pressure can be calculated above which subharmonic oscillations of microbubbles are initiated. Interestingly, earlier experimental studies on coated microbubbles demonstrated that the threshold for these bubbles is much lower than predicted by the traditional linear viscoelastic shell models. This paper presents an experimental study on the subharmonic behavior of differently sized individual phospholipid coated microbubbles. The radial subharmonic response of the microbubbles was recorded with the Brandaris ultra high-speed camera as a function of both the amplitude and the frequency of the driving pulse. Threshold pressures for subharmonic generation as low as 5 kPa were found near a driving frequency equal to twice the resonance frequency of the bubble. An explanation for this low threshold pressure is provided by the shell buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499–3505 (2005)] . It is shown that the change in the elasticity of the bubble shell as a function of bubble radius as proposed in this model, enhances the subharmonic behavior of the microbubbles.",
keywords = "lipid bilayers, METIS-269537, bioacoustics, Bubbles, IR-79274, ultrasonic imaging",
author = "J. Sijl and B. Dollet and M.L.J. Overvelde and V. Garbin and Valeria Garbin and Timo Rozendal and {de Jong}, N. and Detlef Lohse and Michel Versluis",
year = "2010",
doi = "10.1121/1.3493443",
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volume = "128",
pages = "3239--3252",
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Sijl, J, Dollet, B, Overvelde, MLJ, Garbin, V, Garbin, V, Rozendal, T, de Jong, N, Lohse, D & Versluis, M 2010, 'Subharmonic behavior of phospholipid-coated ultrasound contrast agent microbubbles' Journal of the Acoustical Society of America, vol. 128, no. 5, pp. 3239-3252. https://doi.org/10.1121/1.3493443

Subharmonic behavior of phospholipid-coated ultrasound contrast agent microbubbles. / Sijl, J.; Dollet, B.; Overvelde, M.L.J.; Garbin, V.; Garbin, Valeria; Rozendal, Timo; de Jong, N.; Lohse, Detlef; Versluis, Michel.

In: Journal of the Acoustical Society of America, Vol. 128, No. 5, 2010, p. 3239-3252.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Subharmonic behavior of phospholipid-coated ultrasound contrast agent microbubbles

AU - Sijl, J.

AU - Dollet, B.

AU - Overvelde, M.L.J.

AU - Garbin, V.

AU - Garbin, Valeria

AU - Rozendal, Timo

AU - de Jong, N.

AU - Lohse, Detlef

AU - Versluis, Michel

PY - 2010

Y1 - 2010

N2 - Coated microbubbles, unlike tissue are able to scatter sound subharmonically. Therefore, the subharmonic behavior of coated microbubbles can be used to enhance the contrast in ultrasound contrast imaging. Theoretically, a threshold amplitude of the driving pressure can be calculated above which subharmonic oscillations of microbubbles are initiated. Interestingly, earlier experimental studies on coated microbubbles demonstrated that the threshold for these bubbles is much lower than predicted by the traditional linear viscoelastic shell models. This paper presents an experimental study on the subharmonic behavior of differently sized individual phospholipid coated microbubbles. The radial subharmonic response of the microbubbles was recorded with the Brandaris ultra high-speed camera as a function of both the amplitude and the frequency of the driving pulse. Threshold pressures for subharmonic generation as low as 5 kPa were found near a driving frequency equal to twice the resonance frequency of the bubble. An explanation for this low threshold pressure is provided by the shell buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499–3505 (2005)] . It is shown that the change in the elasticity of the bubble shell as a function of bubble radius as proposed in this model, enhances the subharmonic behavior of the microbubbles.

AB - Coated microbubbles, unlike tissue are able to scatter sound subharmonically. Therefore, the subharmonic behavior of coated microbubbles can be used to enhance the contrast in ultrasound contrast imaging. Theoretically, a threshold amplitude of the driving pressure can be calculated above which subharmonic oscillations of microbubbles are initiated. Interestingly, earlier experimental studies on coated microbubbles demonstrated that the threshold for these bubbles is much lower than predicted by the traditional linear viscoelastic shell models. This paper presents an experimental study on the subharmonic behavior of differently sized individual phospholipid coated microbubbles. The radial subharmonic response of the microbubbles was recorded with the Brandaris ultra high-speed camera as a function of both the amplitude and the frequency of the driving pulse. Threshold pressures for subharmonic generation as low as 5 kPa were found near a driving frequency equal to twice the resonance frequency of the bubble. An explanation for this low threshold pressure is provided by the shell buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499–3505 (2005)] . It is shown that the change in the elasticity of the bubble shell as a function of bubble radius as proposed in this model, enhances the subharmonic behavior of the microbubbles.

KW - lipid bilayers

KW - METIS-269537

KW - bioacoustics

KW - Bubbles

KW - IR-79274

KW - ultrasonic imaging

U2 - 10.1121/1.3493443

DO - 10.1121/1.3493443

M3 - Article

VL - 128

SP - 3239

EP - 3252

JO - Journal of the Acoustical Society of America

JF - Journal of the Acoustical Society of America

SN - 0001-4966

IS - 5

ER -