Abstract
| Original language | Undefined |
|---|---|
| Pages (from-to) | 3239-3252 |
| Number of pages | 14 |
| Journal | Journal of the Acoustical Society of America |
| Volume | 128 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2010 |
Keywords
- lipid bilayers
- METIS-269537
- bioacoustics
- Bubbles
- IR-79274
- ultrasonic imaging
Cite this
}
Subharmonic behavior of phospholipid-coated ultrasound contrast agent microbubbles. / Sijl, J.; Dollet, B.; Overvelde, M.L.J.; Garbin, V.; Garbin, Valeria; Rozendal, Timo; de Jong, N.; Lohse, Detlef; Versluis, Michel.
In: Journal of the Acoustical Society of America, Vol. 128, No. 5, 2010, p. 3239-3252.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Subharmonic behavior of phospholipid-coated ultrasound contrast agent microbubbles
AU - Sijl, J.
AU - Dollet, B.
AU - Overvelde, M.L.J.
AU - Garbin, V.
AU - Garbin, Valeria
AU - Rozendal, Timo
AU - de Jong, N.
AU - Lohse, Detlef
AU - Versluis, Michel
PY - 2010
Y1 - 2010
N2 - Coated microbubbles, unlike tissue are able to scatter sound subharmonically. Therefore, the subharmonic behavior of coated microbubbles can be used to enhance the contrast in ultrasound contrast imaging. Theoretically, a threshold amplitude of the driving pressure can be calculated above which subharmonic oscillations of microbubbles are initiated. Interestingly, earlier experimental studies on coated microbubbles demonstrated that the threshold for these bubbles is much lower than predicted by the traditional linear viscoelastic shell models. This paper presents an experimental study on the subharmonic behavior of differently sized individual phospholipid coated microbubbles. The radial subharmonic response of the microbubbles was recorded with the Brandaris ultra high-speed camera as a function of both the amplitude and the frequency of the driving pulse. Threshold pressures for subharmonic generation as low as 5 kPa were found near a driving frequency equal to twice the resonance frequency of the bubble. An explanation for this low threshold pressure is provided by the shell buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499–3505 (2005)] . It is shown that the change in the elasticity of the bubble shell as a function of bubble radius as proposed in this model, enhances the subharmonic behavior of the microbubbles.
AB - Coated microbubbles, unlike tissue are able to scatter sound subharmonically. Therefore, the subharmonic behavior of coated microbubbles can be used to enhance the contrast in ultrasound contrast imaging. Theoretically, a threshold amplitude of the driving pressure can be calculated above which subharmonic oscillations of microbubbles are initiated. Interestingly, earlier experimental studies on coated microbubbles demonstrated that the threshold for these bubbles is much lower than predicted by the traditional linear viscoelastic shell models. This paper presents an experimental study on the subharmonic behavior of differently sized individual phospholipid coated microbubbles. The radial subharmonic response of the microbubbles was recorded with the Brandaris ultra high-speed camera as a function of both the amplitude and the frequency of the driving pulse. Threshold pressures for subharmonic generation as low as 5 kPa were found near a driving frequency equal to twice the resonance frequency of the bubble. An explanation for this low threshold pressure is provided by the shell buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499–3505 (2005)] . It is shown that the change in the elasticity of the bubble shell as a function of bubble radius as proposed in this model, enhances the subharmonic behavior of the microbubbles.
KW - lipid bilayers
KW - METIS-269537
KW - bioacoustics
KW - Bubbles
KW - IR-79274
KW - ultrasonic imaging
U2 - 10.1121/1.3493443
DO - 10.1121/1.3493443
M3 - Article
VL - 128
SP - 3239
EP - 3252
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
SN - 0001-4966
IS - 5
ER -