Subharmonic spectroscopy of ultrasound contrast agents

Telli Faez*, Marcia Emmer, Margreet Docter, Michel Versluis, Nico De Jong

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

3 Citations (Scopus)


We have investigated the subharmonic vibration of BR14 (Bracco Research S.A., Geneva, Switzerland) contrast agent microbubbles between 8-11 MHz. The response of the bubbles is recorded optically with the ultrafast recording camera (Brandaris 128) at three acoustic pressures 50, 100 and 120 kPa. The vibration of the microbubbles as a function of excitation frequency is measured and frequency content is determined. 40% of studied bubbles show subharmonic oscillations. For bubbles smaller than 3m in diameter the driving frequency of maximum subharmonic response increases for increasing pressures opposite to what has been reported for larger bubbles (>3μm).

Original languageEnglish
Title of host publication2010 IEEE International Ultrasonics Symposium, IUS 2010
Number of pages3
Publication statusPublished - 1 Dec 2010
EventIEEE International Ultrasonics Symposium, IUS 2010 - San Diego, United States
Duration: 11 Oct 201014 Oct 2010

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117


ConferenceIEEE International Ultrasonics Symposium, IUS 2010
Abbreviated titleIUS
Country/TerritoryUnited States
CitySan Diego


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