Submicron-surface structured tricalcium phosphate ceramic enhances the bone regeneration in canine spine environment

Rongquan Duan, D. Barbieri, Xiaoman Luo, J. Weng, Joost Dick de Bruijn, Huipin Yuan

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Abstract

Calcium phosphate ceramics with submicron-scaled surface structure can trigger bone formation in non-osseous sites and are expected to enhance bone formation in spine environment. In this study, two tricalcium phosphate ceramics having either a submicron-scaled surface structure (TCP-S) or a micron-scaled one (TCP-B) were prepared and characterized regarding their physicochemical properties. Granules (size 1–2 mm) of both materials were implanted on either left or right side of spinous process, between the two lumbar vertebrae (L3-L4), and in paraspinal muscle of eight beagles. After 12 weeks of implantation, ectopic bone was observed in muscle in TCP-S explants (7.7 ± 3.7%), confirming their ability to inductively form bone in non-osseous sites. In contrast, TCP-B implants did not lead to bone formation in muscle. Abundant bone (34.1 ± 6.6%) was formed within TCP-S implants beside the two spinous processes, while limited bone (5.1 ± 4.5%) was seen in TCP-B. Furthermore, the material resorption of TCP-S was more pronounced than that of TCP-B in both the muscle and spine environments. The results herein indicate that the submicron-scaled surface structured tricalcium phosphate ceramic could enhance bone regeneration as compared to the micron-scaled one in spine environment
Original languageEnglish
Pages (from-to)1865-1873
JournalJournal of orthopaedic research
Volume34
Issue number11
DOIs
Publication statusPublished - 2016

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Bone Regeneration
Canidae
Spine
Osteogenesis
Bone and Bones
Muscles
Paraspinal Muscles
Lumbar Vertebrae
Ceramics
tricalcium phosphate

Keywords

  • IR-103536
  • METIS-321105

Cite this

Duan, Rongquan ; Barbieri, D. ; Luo, Xiaoman ; Weng, J. ; de Bruijn, Joost Dick ; Yuan, Huipin. / Submicron-surface structured tricalcium phosphate ceramic enhances the bone regeneration in canine spine environment. In: Journal of orthopaedic research. 2016 ; Vol. 34, No. 11. pp. 1865-1873.
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abstract = "Calcium phosphate ceramics with submicron-scaled surface structure can trigger bone formation in non-osseous sites and are expected to enhance bone formation in spine environment. In this study, two tricalcium phosphate ceramics having either a submicron-scaled surface structure (TCP-S) or a micron-scaled one (TCP-B) were prepared and characterized regarding their physicochemical properties. Granules (size 1–2 mm) of both materials were implanted on either left or right side of spinous process, between the two lumbar vertebrae (L3-L4), and in paraspinal muscle of eight beagles. After 12 weeks of implantation, ectopic bone was observed in muscle in TCP-S explants (7.7 ± 3.7{\%}), confirming their ability to inductively form bone in non-osseous sites. In contrast, TCP-B implants did not lead to bone formation in muscle. Abundant bone (34.1 ± 6.6{\%}) was formed within TCP-S implants beside the two spinous processes, while limited bone (5.1 ± 4.5{\%}) was seen in TCP-B. Furthermore, the material resorption of TCP-S was more pronounced than that of TCP-B in both the muscle and spine environments. The results herein indicate that the submicron-scaled surface structured tricalcium phosphate ceramic could enhance bone regeneration as compared to the micron-scaled one in spine environment",
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Submicron-surface structured tricalcium phosphate ceramic enhances the bone regeneration in canine spine environment. / Duan, Rongquan; Barbieri, D.; Luo, Xiaoman; Weng, J.; de Bruijn, Joost Dick; Yuan, Huipin.

In: Journal of orthopaedic research, Vol. 34, No. 11, 2016, p. 1865-1873.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Submicron-surface structured tricalcium phosphate ceramic enhances the bone regeneration in canine spine environment

AU - Duan, Rongquan

AU - Barbieri, D.

AU - Luo, Xiaoman

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AU - de Bruijn, Joost Dick

AU - Yuan, Huipin

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N2 - Calcium phosphate ceramics with submicron-scaled surface structure can trigger bone formation in non-osseous sites and are expected to enhance bone formation in spine environment. In this study, two tricalcium phosphate ceramics having either a submicron-scaled surface structure (TCP-S) or a micron-scaled one (TCP-B) were prepared and characterized regarding their physicochemical properties. Granules (size 1–2 mm) of both materials were implanted on either left or right side of spinous process, between the two lumbar vertebrae (L3-L4), and in paraspinal muscle of eight beagles. After 12 weeks of implantation, ectopic bone was observed in muscle in TCP-S explants (7.7 ± 3.7%), confirming their ability to inductively form bone in non-osseous sites. In contrast, TCP-B implants did not lead to bone formation in muscle. Abundant bone (34.1 ± 6.6%) was formed within TCP-S implants beside the two spinous processes, while limited bone (5.1 ± 4.5%) was seen in TCP-B. Furthermore, the material resorption of TCP-S was more pronounced than that of TCP-B in both the muscle and spine environments. The results herein indicate that the submicron-scaled surface structured tricalcium phosphate ceramic could enhance bone regeneration as compared to the micron-scaled one in spine environment

AB - Calcium phosphate ceramics with submicron-scaled surface structure can trigger bone formation in non-osseous sites and are expected to enhance bone formation in spine environment. In this study, two tricalcium phosphate ceramics having either a submicron-scaled surface structure (TCP-S) or a micron-scaled one (TCP-B) were prepared and characterized regarding their physicochemical properties. Granules (size 1–2 mm) of both materials were implanted on either left or right side of spinous process, between the two lumbar vertebrae (L3-L4), and in paraspinal muscle of eight beagles. After 12 weeks of implantation, ectopic bone was observed in muscle in TCP-S explants (7.7 ± 3.7%), confirming their ability to inductively form bone in non-osseous sites. In contrast, TCP-B implants did not lead to bone formation in muscle. Abundant bone (34.1 ± 6.6%) was formed within TCP-S implants beside the two spinous processes, while limited bone (5.1 ± 4.5%) was seen in TCP-B. Furthermore, the material resorption of TCP-S was more pronounced than that of TCP-B in both the muscle and spine environments. The results herein indicate that the submicron-scaled surface structured tricalcium phosphate ceramic could enhance bone regeneration as compared to the micron-scaled one in spine environment

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