Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1865-1873 |
| Journal | Journal of orthopaedic research |
| Volume | 34 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2016 |
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Keywords
- IR-103536
- METIS-321105
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Submicron-surface structured tricalcium phosphate ceramic enhances the bone regeneration in canine spine environment. / Duan, Rongquan; Barbieri, D.; Luo, Xiaoman; Weng, J.; de Bruijn, Joost Dick; Yuan, Huipin.
In: Journal of orthopaedic research, Vol. 34, No. 11, 2016, p. 1865-1873.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Submicron-surface structured tricalcium phosphate ceramic enhances the bone regeneration in canine spine environment
AU - Duan, Rongquan
AU - Barbieri, D.
AU - Luo, Xiaoman
AU - Weng, J.
AU - de Bruijn, Joost Dick
AU - Yuan, Huipin
PY - 2016
Y1 - 2016
N2 - Calcium phosphate ceramics with submicron-scaled surface structure can trigger bone formation in non-osseous sites and are expected to enhance bone formation in spine environment. In this study, two tricalcium phosphate ceramics having either a submicron-scaled surface structure (TCP-S) or a micron-scaled one (TCP-B) were prepared and characterized regarding their physicochemical properties. Granules (size 1–2 mm) of both materials were implanted on either left or right side of spinous process, between the two lumbar vertebrae (L3-L4), and in paraspinal muscle of eight beagles. After 12 weeks of implantation, ectopic bone was observed in muscle in TCP-S explants (7.7 ± 3.7%), confirming their ability to inductively form bone in non-osseous sites. In contrast, TCP-B implants did not lead to bone formation in muscle. Abundant bone (34.1 ± 6.6%) was formed within TCP-S implants beside the two spinous processes, while limited bone (5.1 ± 4.5%) was seen in TCP-B. Furthermore, the material resorption of TCP-S was more pronounced than that of TCP-B in both the muscle and spine environments. The results herein indicate that the submicron-scaled surface structured tricalcium phosphate ceramic could enhance bone regeneration as compared to the micron-scaled one in spine environment
AB - Calcium phosphate ceramics with submicron-scaled surface structure can trigger bone formation in non-osseous sites and are expected to enhance bone formation in spine environment. In this study, two tricalcium phosphate ceramics having either a submicron-scaled surface structure (TCP-S) or a micron-scaled one (TCP-B) were prepared and characterized regarding their physicochemical properties. Granules (size 1–2 mm) of both materials were implanted on either left or right side of spinous process, between the two lumbar vertebrae (L3-L4), and in paraspinal muscle of eight beagles. After 12 weeks of implantation, ectopic bone was observed in muscle in TCP-S explants (7.7 ± 3.7%), confirming their ability to inductively form bone in non-osseous sites. In contrast, TCP-B implants did not lead to bone formation in muscle. Abundant bone (34.1 ± 6.6%) was formed within TCP-S implants beside the two spinous processes, while limited bone (5.1 ± 4.5%) was seen in TCP-B. Furthermore, the material resorption of TCP-S was more pronounced than that of TCP-B in both the muscle and spine environments. The results herein indicate that the submicron-scaled surface structured tricalcium phosphate ceramic could enhance bone regeneration as compared to the micron-scaled one in spine environment
KW - IR-103536
KW - METIS-321105
U2 - 10.1002/jor.23201
DO - 10.1002/jor.23201
M3 - Article
VL - 34
SP - 1865
EP - 1873
JO - Journal of orthopaedic research
JF - Journal of orthopaedic research
SN - 0736-0266
IS - 11
ER -