Substantial rate enhancements of the esterification reaction of phthalic anhydride with methanol at high pressure and using supercritical CO2 as a co-solvent in a glass microreactor

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Abstract

The esterification reaction of phthalic anhydride with methanol was performed at different temperatures in a continuous flow glass microreactor at pressures up to 110 bar and using supercritical CO2 as a co-solvent. The design is such that supercritical CO2 can be generated inside the microreactor. Substantial rate enhancements were obtained, viz. a 53-fold increase was obtained at 110 bar and 60 °C. Supercritical CO2 as a co-solvent gave rise to a 5400-fold increase (both with respect to batch experiments at 1 bar at the same temperature).
Original languageUndefined
Pages (from-to)1345-1351
Number of pages7
JournalLab on a chip
Volume7
DOIs
Publication statusPublished - 2007

Keywords

  • METIS-241456
  • IR-74657

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