Subthalamic and pallidal neurons are modulated during externally cued movements in Parkinson's disease

Stephanie Tran, Tjitske C. Heida, Janne J.A. Heijs, Tameem Al-Ozzi, Srdjan Sumarac, Frhan I. Alanazi, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Luka Milosevic, Robert Chen, William D. Hutchison*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

External sensory cues can reduce freezing of gait in people with Parkinson's disease (PD), yet the role of the basal ganglia in these movements is unclear. We used microelectrode recordings to examine modulations in single unit (SU) and oscillatory local field potentials (LFP) during auditory-cued rhythmic pedaling movements of the feet. We tested five blocks of increasing cue frequencies (1 Hz, 1.5 Hz, 2 Hz, 2.5 Hz, and 3 Hz) in 24 people with PD undergoing deep brain stimulation surgery of the subthalamic nucleus (STN) or globus pallidus internus (GPi). Single unit firing and beta band LFPs (13–30 Hz) in response to movement onsets or cue onsets were examined. We found that the timing accuracy of foot pedaling decreased with faster cue frequencies. Increasing cue frequencies also attenuated firing rates in both STN and GPi neurons. Peak beta power in the GPi and STN showed different responses to the task. GPi beta power showed persistent suppression with fast cues and phasic modulation with slow cues. STN beta power showed enhanced beta synchronization following movement. STN beta power also correlated with rate of pedaling. Overall, we showed task-related responses in the GPi and STN during auditory-cued movements with differential roles in sensory and motor control. The results suggest a role for both input and output basal ganglia nuclei in auditory rhythmic pacing of gait-like movements in PD.
Original languageEnglish
Article number106384
Number of pages9
JournalNeurobiology of disease
Volume190
Early online date20 Dec 2023
DOIs
Publication statusPublished - Jan 2024

Keywords

  • Intraoperative recording
  • Locomotion
  • Basal ganglia
  • Deep brain stimulation

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