18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis

Ilse J.E. Kouijzer; Marvin A.H. Berrevoets; Erik H.J.G. Aarntzen; Janneke De Vries; Arie P.J. Van Dijk; Wim J.G. Oyen; Lioe Fee de Geus-Oei; Chantal P. Bleeker-Rovers

doi:10.1097/MNM.0000000000000864

¹⁸F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis

Ilse J.E. Kouijzer^* (Corresponding Author), Marvin A.H. Berrevoets, Erik H.J.G. Aarntzen, Janneke De Vries, Arie P.J. Van Dijk, Wim J.G. Oyen, Lioe Fee de Geus-Oei, Chantal P. Bleeker-Rovers

^*Corresponding author for this work

Biomedical Photonic Imaging

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Abstract

Objective The aim of the study was to investigate the value of ¹⁸F-fluorodeoxyglucose positron-emission tomography combined with computed tomography (¹⁸F-FDG-PET/CT) in diagnosing native valve endocarditis (NVE). Patients and methods All patients with bacteremia and suspicion of NVE between January 2013 and June 2016 were identified from the hospitals' register and retrospectively included if echocardiography and ¹⁸F-FDG-PET/CT were performed within 14 days. ¹⁸F-FDG-PET/CT scans were scored independently by two nuclear medicine physicians. ¹⁸F-FDG-PET/CT was compared with the modified-Duke criteria and a multidisciplinary consensus. Results A total of 88 patients were included. In 10 patients with definite NVE according to the modified-Duke criteria, three (30.0%) patients had increased ¹⁸F-FDG uptake in or around the heart valves and seven (70.0%) patients had no increased ¹⁸F-FDG uptake. In patients without definite NVE according to the modified-Duke criteria, 89.7% (70/78) of the patients had no increased ¹⁸F-FDG uptake in or around the heart valves. Of all 20 patients with NVE according to multidisciplinary consensus, nine (45.0%) patients had increased ¹⁸F-FDG uptake in or around the heart valves and 11 (55.0%) patients had a normal ¹⁸F-FDG-PET/CT result. Conclusion A negative ¹⁸F-FDG-PET/CT result should not be interpreted as an exclusion of NVE. In patients with possible or rejected NVE according to the modified-Duke criteria, ¹⁸F-FDG-PET/CT could be used in case of sustained suspicion of NVE owing to its high specificity in case of abnormal FDG uptake at the valve region. ¹⁸F-FDG-PET/CT is important for detecting metastatic infection which already warrants the need to perform ¹⁸F-FDG-PET/CT in all patients with suspected NVE.

Original language	English
Pages (from-to)	747-752
Number of pages	6
Journal	Nuclear medicine communications
Volume	39
Issue number	8
DOIs	https://doi.org/10.1097/MNM.0000000000000864
Publication status	Published - 1 Aug 2018

Keywords

F-fluorodeoxyglucose positron-emission tomography combined with computed tomography
Duke criteria
Endocarditis
Native valve
n/a OA procedure

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10.1097/MNM.0000000000000864

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Kouijzer, I. J. E., Berrevoets, M. A. H., Aarntzen, E. H. J. G., De Vries, J., Van Dijk, A. P. J., Oyen, W. J. G., de Geus-Oei, L. F., & Bleeker-Rovers, C. P. (2018). ¹⁸F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis. Nuclear medicine communications, 39(8), 747-752. https://doi.org/10.1097/MNM.0000000000000864

@article{8e0ea7a24eb84f04afd5317b47665dcb,

title = "18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis",

abstract = "Objective The aim of the study was to investigate the value of 18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography (18F-FDG-PET/CT) in diagnosing native valve endocarditis (NVE). Patients and methods All patients with bacteremia and suspicion of NVE between January 2013 and June 2016 were identified from the hospitals' register and retrospectively included if echocardiography and 18F-FDG-PET/CT were performed within 14 days. 18F-FDG-PET/CT scans were scored independently by two nuclear medicine physicians. 18F-FDG-PET/CT was compared with the modified-Duke criteria and a multidisciplinary consensus. Results A total of 88 patients were included. In 10 patients with definite NVE according to the modified-Duke criteria, three (30.0%) patients had increased 18F-FDG uptake in or around the heart valves and seven (70.0%) patients had no increased 18F-FDG uptake. In patients without definite NVE according to the modified-Duke criteria, 89.7% (70/78) of the patients had no increased 18F-FDG uptake in or around the heart valves. Of all 20 patients with NVE according to multidisciplinary consensus, nine (45.0%) patients had increased 18F-FDG uptake in or around the heart valves and 11 (55.0%) patients had a normal 18F-FDG-PET/CT result. Conclusion A negative 18F-FDG-PET/CT result should not be interpreted as an exclusion of NVE. In patients with possible or rejected NVE according to the modified-Duke criteria, 18F-FDG-PET/CT could be used in case of sustained suspicion of NVE owing to its high specificity in case of abnormal FDG uptake at the valve region. 18F-FDG-PET/CT is important for detecting metastatic infection which already warrants the need to perform 18F-FDG-PET/CT in all patients with suspected NVE.",

keywords = "F-fluorodeoxyglucose positron-emission tomography combined with computed tomography, Duke criteria, Endocarditis, Native valve, n/a OA procedure",

author = "Kouijzer, {Ilse J.E.} and Berrevoets, {Marvin A.H.} and Aarntzen, {Erik H.J.G.} and {De Vries}, Janneke and {Van Dijk}, {Arie P.J.} and Oyen, {Wim J.G.} and {de Geus-Oei}, {Lioe Fee} and Bleeker-Rovers, {Chantal P.}",

year = "2018",

month = aug,

day = "1",

doi = "10.1097/MNM.0000000000000864",

language = "English",

volume = "39",

pages = "747--752",

journal = "Nuclear medicine communications",

issn = "0143-3636",

publisher = "Lippincott Williams & Wilkins",

number = "8",

}

Kouijzer, IJE, Berrevoets, MAH, Aarntzen, EHJG, De Vries, J, Van Dijk, APJ, Oyen, WJG, de Geus-Oei, LF & Bleeker-Rovers, CP 2018, '¹⁸F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis', Nuclear medicine communications, vol. 39, no. 8, pp. 747-752. https://doi.org/10.1097/MNM.0000000000000864

¹⁸F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis. / Kouijzer, Ilse J.E. (Corresponding Author); Berrevoets, Marvin A.H.; Aarntzen, Erik H.J.G. et al.
In: Nuclear medicine communications, Vol. 39, No. 8, 01.08.2018, p. 747-752.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - 18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis

AU - Kouijzer, Ilse J.E.

AU - Berrevoets, Marvin A.H.

AU - Aarntzen, Erik H.J.G.

AU - De Vries, Janneke

AU - Van Dijk, Arie P.J.

AU - Oyen, Wim J.G.

AU - de Geus-Oei, Lioe Fee

AU - Bleeker-Rovers, Chantal P.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Objective The aim of the study was to investigate the value of 18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography (18F-FDG-PET/CT) in diagnosing native valve endocarditis (NVE). Patients and methods All patients with bacteremia and suspicion of NVE between January 2013 and June 2016 were identified from the hospitals' register and retrospectively included if echocardiography and 18F-FDG-PET/CT were performed within 14 days. 18F-FDG-PET/CT scans were scored independently by two nuclear medicine physicians. 18F-FDG-PET/CT was compared with the modified-Duke criteria and a multidisciplinary consensus. Results A total of 88 patients were included. In 10 patients with definite NVE according to the modified-Duke criteria, three (30.0%) patients had increased 18F-FDG uptake in or around the heart valves and seven (70.0%) patients had no increased 18F-FDG uptake. In patients without definite NVE according to the modified-Duke criteria, 89.7% (70/78) of the patients had no increased 18F-FDG uptake in or around the heart valves. Of all 20 patients with NVE according to multidisciplinary consensus, nine (45.0%) patients had increased 18F-FDG uptake in or around the heart valves and 11 (55.0%) patients had a normal 18F-FDG-PET/CT result. Conclusion A negative 18F-FDG-PET/CT result should not be interpreted as an exclusion of NVE. In patients with possible or rejected NVE according to the modified-Duke criteria, 18F-FDG-PET/CT could be used in case of sustained suspicion of NVE owing to its high specificity in case of abnormal FDG uptake at the valve region. 18F-FDG-PET/CT is important for detecting metastatic infection which already warrants the need to perform 18F-FDG-PET/CT in all patients with suspected NVE.

AB - Objective The aim of the study was to investigate the value of 18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography (18F-FDG-PET/CT) in diagnosing native valve endocarditis (NVE). Patients and methods All patients with bacteremia and suspicion of NVE between January 2013 and June 2016 were identified from the hospitals' register and retrospectively included if echocardiography and 18F-FDG-PET/CT were performed within 14 days. 18F-FDG-PET/CT scans were scored independently by two nuclear medicine physicians. 18F-FDG-PET/CT was compared with the modified-Duke criteria and a multidisciplinary consensus. Results A total of 88 patients were included. In 10 patients with definite NVE according to the modified-Duke criteria, three (30.0%) patients had increased 18F-FDG uptake in or around the heart valves and seven (70.0%) patients had no increased 18F-FDG uptake. In patients without definite NVE according to the modified-Duke criteria, 89.7% (70/78) of the patients had no increased 18F-FDG uptake in or around the heart valves. Of all 20 patients with NVE according to multidisciplinary consensus, nine (45.0%) patients had increased 18F-FDG uptake in or around the heart valves and 11 (55.0%) patients had a normal 18F-FDG-PET/CT result. Conclusion A negative 18F-FDG-PET/CT result should not be interpreted as an exclusion of NVE. In patients with possible or rejected NVE according to the modified-Duke criteria, 18F-FDG-PET/CT could be used in case of sustained suspicion of NVE owing to its high specificity in case of abnormal FDG uptake at the valve region. 18F-FDG-PET/CT is important for detecting metastatic infection which already warrants the need to perform 18F-FDG-PET/CT in all patients with suspected NVE.

KW - F-fluorodeoxyglucose positron-emission tomography combined with computed tomography

KW - Duke criteria

KW - Endocarditis

KW - Native valve

KW - n/a OA procedure

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U2 - 10.1097/MNM.0000000000000864

DO - 10.1097/MNM.0000000000000864

M3 - Article

AN - SCOPUS:85049196366

SN - 0143-3636

VL - 39

SP - 747

EP - 752

JO - Nuclear medicine communications

JF - Nuclear medicine communications

IS - 8

ER -

¹⁸F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis

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