18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis

Ilse J.E. Kouijzer (Corresponding Author), Marvin A.H. Berrevoets, Erik H.J.G. Aarntzen, Janneke De Vries, Arie P.J. Van Dijk, Wim J.G. Oyen, Lioe Fee De Geus-Oei, Chantal P. Bleeker-Rovers

Research output: Contribution to journalArticle

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Abstract

Objective The aim of the study was to investigate the value of 18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography (18F-FDG-PET/CT) in diagnosing native valve endocarditis (NVE). Patients and methods All patients with bacteremia and suspicion of NVE between January 2013 and June 2016 were identified from the hospitals' register and retrospectively included if echocardiography and 18F-FDG-PET/CT were performed within 14 days. 18F-FDG-PET/CT scans were scored independently by two nuclear medicine physicians. 18F-FDG-PET/CT was compared with the modified-Duke criteria and a multidisciplinary consensus. Results A total of 88 patients were included. In 10 patients with definite NVE according to the modified-Duke criteria, three (30.0%) patients had increased 18F-FDG uptake in or around the heart valves and seven (70.0%) patients had no increased 18F-FDG uptake. In patients without definite NVE according to the modified-Duke criteria, 89.7% (70/78) of the patients had no increased 18F-FDG uptake in or around the heart valves. Of all 20 patients with NVE according to multidisciplinary consensus, nine (45.0%) patients had increased 18F-FDG uptake in or around the heart valves and 11 (55.0%) patients had a normal 18F-FDG-PET/CT result. Conclusion A negative 18F-FDG-PET/CT result should not be interpreted as an exclusion of NVE. In patients with possible or rejected NVE according to the modified-Duke criteria, 18F-FDG-PET/CT could be used in case of sustained suspicion of NVE owing to its high specificity in case of abnormal FDG uptake at the valve region. 18F-FDG-PET/CT is important for detecting metastatic infection which already warrants the need to perform 18F-FDG-PET/CT in all patients with suspected NVE.

LanguageEnglish
Pages747-752
Number of pages6
JournalNuclear medicine communications
Volume39
Issue number8
DOIs
StatePublished - 1 Aug 2018

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Fluorodeoxyglucose F18
Endocarditis
Positron-Emission Tomography
Tomography
Heart Valves
Nuclear Medicine
Bacteremia
Echocardiography

Keywords

  • F-fluorodeoxyglucose positron-emission tomography combined with computed tomography
  • Duke criteria
  • endocarditis
  • native valve
  • Hybride overig

Cite this

Kouijzer, I. J. E., Berrevoets, M. A. H., Aarntzen, E. H. J. G., De Vries, J., Van Dijk, A. P. J., Oyen, W. J. G., ... Bleeker-Rovers, C. P. (2018). 18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis. Nuclear medicine communications, 39(8), 747-752. DOI: 10.1097/MNM.0000000000000864
Kouijzer, Ilse J.E. ; Berrevoets, Marvin A.H. ; Aarntzen, Erik H.J.G. ; De Vries, Janneke ; Van Dijk, Arie P.J. ; Oyen, Wim J.G. ; De Geus-Oei, Lioe Fee ; Bleeker-Rovers, Chantal P./ 18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis. In: Nuclear medicine communications. 2018 ; Vol. 39, No. 8. pp. 747-752
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abstract = "Objective The aim of the study was to investigate the value of 18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography (18F-FDG-PET/CT) in diagnosing native valve endocarditis (NVE). Patients and methods All patients with bacteremia and suspicion of NVE between January 2013 and June 2016 were identified from the hospitals' register and retrospectively included if echocardiography and 18F-FDG-PET/CT were performed within 14 days. 18F-FDG-PET/CT scans were scored independently by two nuclear medicine physicians. 18F-FDG-PET/CT was compared with the modified-Duke criteria and a multidisciplinary consensus. Results A total of 88 patients were included. In 10 patients with definite NVE according to the modified-Duke criteria, three (30.0{\%}) patients had increased 18F-FDG uptake in or around the heart valves and seven (70.0{\%}) patients had no increased 18F-FDG uptake. In patients without definite NVE according to the modified-Duke criteria, 89.7{\%} (70/78) of the patients had no increased 18F-FDG uptake in or around the heart valves. Of all 20 patients with NVE according to multidisciplinary consensus, nine (45.0{\%}) patients had increased 18F-FDG uptake in or around the heart valves and 11 (55.0{\%}) patients had a normal 18F-FDG-PET/CT result. Conclusion A negative 18F-FDG-PET/CT result should not be interpreted as an exclusion of NVE. In patients with possible or rejected NVE according to the modified-Duke criteria, 18F-FDG-PET/CT could be used in case of sustained suspicion of NVE owing to its high specificity in case of abnormal FDG uptake at the valve region. 18F-FDG-PET/CT is important for detecting metastatic infection which already warrants the need to perform 18F-FDG-PET/CT in all patients with suspected NVE.",
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18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis. / Kouijzer, Ilse J.E. (Corresponding Author); Berrevoets, Marvin A.H.; Aarntzen, Erik H.J.G.; De Vries, Janneke; Van Dijk, Arie P.J.; Oyen, Wim J.G.; De Geus-Oei, Lioe Fee; Bleeker-Rovers, Chantal P.

In: Nuclear medicine communications, Vol. 39, No. 8, 01.08.2018, p. 747-752.

Research output: Contribution to journalArticle

TY - JOUR

T1 - 18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography as a diagnostic tool in native valve endocarditis

AU - Kouijzer,Ilse J.E.

AU - Berrevoets,Marvin A.H.

AU - Aarntzen,Erik H.J.G.

AU - De Vries,Janneke

AU - Van Dijk,Arie P.J.

AU - Oyen,Wim J.G.

AU - De Geus-Oei,Lioe Fee

AU - Bleeker-Rovers,Chantal P.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Objective The aim of the study was to investigate the value of 18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography (18F-FDG-PET/CT) in diagnosing native valve endocarditis (NVE). Patients and methods All patients with bacteremia and suspicion of NVE between January 2013 and June 2016 were identified from the hospitals' register and retrospectively included if echocardiography and 18F-FDG-PET/CT were performed within 14 days. 18F-FDG-PET/CT scans were scored independently by two nuclear medicine physicians. 18F-FDG-PET/CT was compared with the modified-Duke criteria and a multidisciplinary consensus. Results A total of 88 patients were included. In 10 patients with definite NVE according to the modified-Duke criteria, three (30.0%) patients had increased 18F-FDG uptake in or around the heart valves and seven (70.0%) patients had no increased 18F-FDG uptake. In patients without definite NVE according to the modified-Duke criteria, 89.7% (70/78) of the patients had no increased 18F-FDG uptake in or around the heart valves. Of all 20 patients with NVE according to multidisciplinary consensus, nine (45.0%) patients had increased 18F-FDG uptake in or around the heart valves and 11 (55.0%) patients had a normal 18F-FDG-PET/CT result. Conclusion A negative 18F-FDG-PET/CT result should not be interpreted as an exclusion of NVE. In patients with possible or rejected NVE according to the modified-Duke criteria, 18F-FDG-PET/CT could be used in case of sustained suspicion of NVE owing to its high specificity in case of abnormal FDG uptake at the valve region. 18F-FDG-PET/CT is important for detecting metastatic infection which already warrants the need to perform 18F-FDG-PET/CT in all patients with suspected NVE.

AB - Objective The aim of the study was to investigate the value of 18F-fluorodeoxyglucose positron-emission tomography combined with computed tomography (18F-FDG-PET/CT) in diagnosing native valve endocarditis (NVE). Patients and methods All patients with bacteremia and suspicion of NVE between January 2013 and June 2016 were identified from the hospitals' register and retrospectively included if echocardiography and 18F-FDG-PET/CT were performed within 14 days. 18F-FDG-PET/CT scans were scored independently by two nuclear medicine physicians. 18F-FDG-PET/CT was compared with the modified-Duke criteria and a multidisciplinary consensus. Results A total of 88 patients were included. In 10 patients with definite NVE according to the modified-Duke criteria, three (30.0%) patients had increased 18F-FDG uptake in or around the heart valves and seven (70.0%) patients had no increased 18F-FDG uptake. In patients without definite NVE according to the modified-Duke criteria, 89.7% (70/78) of the patients had no increased 18F-FDG uptake in or around the heart valves. Of all 20 patients with NVE according to multidisciplinary consensus, nine (45.0%) patients had increased 18F-FDG uptake in or around the heart valves and 11 (55.0%) patients had a normal 18F-FDG-PET/CT result. Conclusion A negative 18F-FDG-PET/CT result should not be interpreted as an exclusion of NVE. In patients with possible or rejected NVE according to the modified-Duke criteria, 18F-FDG-PET/CT could be used in case of sustained suspicion of NVE owing to its high specificity in case of abnormal FDG uptake at the valve region. 18F-FDG-PET/CT is important for detecting metastatic infection which already warrants the need to perform 18F-FDG-PET/CT in all patients with suspected NVE.

KW - F-fluorodeoxyglucose positron-emission tomography combined with computed tomography

KW - Duke criteria

KW - endocarditis

KW - native valve

KW - Hybride overig

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U2 - 10.1097/MNM.0000000000000864

DO - 10.1097/MNM.0000000000000864

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JO - Nuclear medicine communications

T2 - Nuclear medicine communications

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