18F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques

H. Hop; S.A. de Boer; M. Reijrink; P.W. Kamphuisen; M.H. de Borst; R.A. Pol; C.J. Zeebregts; J.L. Hillebrands; R.H.J.A. Slart; H.H. Boersma; J. Doorduin; D.J. Mulder

doi:10.1007/s12350-018-1325-5

¹⁸F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques

H. Hop^*, S.A. de Boer, M. Reijrink, P.W. Kamphuisen, M.H. de Borst, R.A. Pol, C.J. Zeebregts, J.L. Hillebrands, R.H.J.A. Slart, H.H. Boersma, J. Doorduin, D.J. Mulder

^*Corresponding author for this work

Biomedical Photonic Imaging

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Abstract

Background: ¹⁸F-NaF positron emission tomography (PET) targets microcalcifications. We compared in vitro microPET assessed ¹⁸F-NaF uptake between culprit and non-culprit human carotid plaques. Furthermore, we compared ¹⁸F-NaF uptake with calcification visualized on microcomputed tomography (microCT).

Methods: Carotid plaques from stroke patients undergoing surgery were incubated in ¹⁸F-NaF and scanned using a microPET and a microCT scan. The average PET assessed ¹⁸F-NaF uptake was expressed as percentage of the incubation dose per gram (%Inc/g). ¹⁸F-NaF PET volume of interest (VOI) was compared with CT calcification VOI.

Results: 23 carotid plaques (17 culprit, 6 non-culprit) were included. The average ¹⁸F-NaF uptake in culprit carotid plaques was comparable with the uptake in non-culprit carotid plaques (median 2.32 %Inc/g [IQR 1.98 to 2.81] vs. median 2.35 %Inc/g [IQR 1.77 to 3.00], P = 0.916). Only a median of 10% (IQR 4 to 25) of CT calcification VOI showed increased ¹⁸F-NaF uptake, while merely a median of 35% (IQR 6 to 42) of ¹⁸F-NaF PET VOI showed calcification on CT.

Conclusions: ¹⁸F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed ¹⁸F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development.

Original language	English
Pages (from-to)	1064-1075
Number of pages	12
Journal	Journal of nuclear cardiology
Volume	26
Issue number	4
DOIs	https://doi.org/10.1007/s12350-018-1325-5
Publication status	Published - 15 Aug 2019

Keywords

F-sodium fluoride (F-NaF)
Calcification
Carotid artery stenosis
PET/CT imaging
Vulnerable atherosclerotic plaque

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Cite this

Hop, H., de Boer, S. A., Reijrink, M., Kamphuisen, P. W., de Borst, M. H., Pol, R. A., Zeebregts, C. J., Hillebrands, J. L., Slart, R. H. J. A., Boersma, H. H., Doorduin, J., & Mulder, D. J. (2019). ¹⁸F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques. Journal of nuclear cardiology, 26(4), 1064-1075. https://doi.org/10.1007/s12350-018-1325-5

@article{a1513fb093294abd9632df315be8f80c,

title = "18F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques",

abstract = "Background: 18F-NaF positron emission tomography (PET) targets microcalcifications. We compared in vitro microPET assessed 18F-NaF uptake between culprit and non-culprit human carotid plaques. Furthermore, we compared 18F-NaF uptake with calcification visualized on microcomputed tomography (microCT).Methods: Carotid plaques from stroke patients undergoing surgery were incubated in 18F-NaF and scanned using a microPET and a microCT scan. The average PET assessed 18F-NaF uptake was expressed as percentage of the incubation dose per gram (%Inc/g). 18F-NaF PET volume of interest (VOI) was compared with CT calcification VOI.Results: 23 carotid plaques (17 culprit, 6 non-culprit) were included. The average 18F-NaF uptake in culprit carotid plaques was comparable with the uptake in non-culprit carotid plaques (median 2.32 %Inc/g [IQR 1.98 to 2.81] vs. median 2.35 %Inc/g [IQR 1.77 to 3.00], P = 0.916). Only a median of 10% (IQR 4 to 25) of CT calcification VOI showed increased 18F-NaF uptake, while merely a median of 35% (IQR 6 to 42) of 18F-NaF PET VOI showed calcification on CT.Conclusions: 18F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed 18F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development.",

keywords = "F-sodium fluoride (F-NaF), Calcification, Carotid artery stenosis, PET/CT imaging, Vulnerable atherosclerotic plaque",

author = "H. Hop and {de Boer}, S.A. and M. Reijrink and P.W. Kamphuisen and {de Borst}, M.H. and R.A. Pol and C.J. Zeebregts and J.L. Hillebrands and R.H.J.A. Slart and H.H. Boersma and J. Doorduin and D.J. Mulder",

year = "2019",

month = aug,

day = "15",

doi = "10.1007/s12350-018-1325-5",

language = "English",

volume = "26",

pages = "1064--1075",

journal = "Journal of nuclear cardiology",

issn = "1071-3581",

publisher = "American Society of Nuclear Cardiology",

number = "4",

}

Hop, H, de Boer, SA, Reijrink, M, Kamphuisen, PW, de Borst, MH, Pol, RA, Zeebregts, CJ, Hillebrands, JL, Slart, RHJA, Boersma, HH, Doorduin, J & Mulder, DJ 2019, '¹⁸F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques', Journal of nuclear cardiology, vol. 26, no. 4, pp. 1064-1075. https://doi.org/10.1007/s12350-018-1325-5

TY - JOUR

T1 - 18F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques

AU - Hop, H.

AU - de Boer, S.A.

AU - Reijrink, M.

AU - Kamphuisen, P.W.

AU - de Borst, M.H.

AU - Pol, R.A.

AU - Zeebregts, C.J.

AU - Hillebrands, J.L.

AU - Slart, R.H.J.A.

AU - Boersma, H.H.

AU - Doorduin, J.

AU - Mulder, D.J.

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Background: 18F-NaF positron emission tomography (PET) targets microcalcifications. We compared in vitro microPET assessed 18F-NaF uptake between culprit and non-culprit human carotid plaques. Furthermore, we compared 18F-NaF uptake with calcification visualized on microcomputed tomography (microCT).Methods: Carotid plaques from stroke patients undergoing surgery were incubated in 18F-NaF and scanned using a microPET and a microCT scan. The average PET assessed 18F-NaF uptake was expressed as percentage of the incubation dose per gram (%Inc/g). 18F-NaF PET volume of interest (VOI) was compared with CT calcification VOI.Results: 23 carotid plaques (17 culprit, 6 non-culprit) were included. The average 18F-NaF uptake in culprit carotid plaques was comparable with the uptake in non-culprit carotid plaques (median 2.32 %Inc/g [IQR 1.98 to 2.81] vs. median 2.35 %Inc/g [IQR 1.77 to 3.00], P = 0.916). Only a median of 10% (IQR 4 to 25) of CT calcification VOI showed increased 18F-NaF uptake, while merely a median of 35% (IQR 6 to 42) of 18F-NaF PET VOI showed calcification on CT.Conclusions: 18F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed 18F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development.

AB - Background: 18F-NaF positron emission tomography (PET) targets microcalcifications. We compared in vitro microPET assessed 18F-NaF uptake between culprit and non-culprit human carotid plaques. Furthermore, we compared 18F-NaF uptake with calcification visualized on microcomputed tomography (microCT).Methods: Carotid plaques from stroke patients undergoing surgery were incubated in 18F-NaF and scanned using a microPET and a microCT scan. The average PET assessed 18F-NaF uptake was expressed as percentage of the incubation dose per gram (%Inc/g). 18F-NaF PET volume of interest (VOI) was compared with CT calcification VOI.Results: 23 carotid plaques (17 culprit, 6 non-culprit) were included. The average 18F-NaF uptake in culprit carotid plaques was comparable with the uptake in non-culprit carotid plaques (median 2.32 %Inc/g [IQR 1.98 to 2.81] vs. median 2.35 %Inc/g [IQR 1.77 to 3.00], P = 0.916). Only a median of 10% (IQR 4 to 25) of CT calcification VOI showed increased 18F-NaF uptake, while merely a median of 35% (IQR 6 to 42) of 18F-NaF PET VOI showed calcification on CT.Conclusions: 18F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed 18F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development.

KW - F-sodium fluoride (F-NaF)

KW - Calcification

KW - Carotid artery stenosis

KW - PET/CT imaging

KW - Vulnerable atherosclerotic plaque

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U2 - 10.1007/s12350-018-1325-5

DO - 10.1007/s12350-018-1325-5

M3 - Article

C2 - 29943142

AN - SCOPUS:85049000064

SN - 1071-3581

VL - 26

SP - 1064

EP - 1075

JO - Journal of nuclear cardiology

JF - Journal of nuclear cardiology

IS - 4

ER -