Superior photoprotective motifs and mechanisms in eumelanins uncovered

Alice Corani, Jannetje Maria Huijser, Thomas Gustavsson, Dimitra Markovitsi, Per-Ake Malmqvist, Alessandro Pezzella, Marco D'Ischia, Villy Sundström

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)

Abstract

Human pigmentation is a complex phenomenon commonly believed to serve a photoprotective function through the generation and strategic localization of black insoluble eumelanin biopolymers in sun exposed areas of the body. Despite compelling biomedical relevance to skin cancer and melanoma, eumelanin photoprotection is still an enigma: What makes this pigment so efficient in dissipating the excess energy brought by harmful UV-light as heat? Why has Nature selected 5,6-dihydroxyindole-2-carboxylic acid (DHICA) as the major building block of the pigment instead of the decarboxylated derivative (DHI)? By using pico- and femtosecond fluorescence spectroscopy we demonstrate herein that the excited state deactivation in DHICA oligomers is 3 orders of magnitude faster compared to DHI oligomers. This drastic effect is attributed to their specific structural patterns enabling multiple pathways of intra- and interunit proton transfer. The discovery that DHICA-based scaffolds specifically confer uniquely robust photoprotective properties to natural eumelanins settles a fundamental gap in the biology of human pigmentation and opens the doorway to attractive advances and applications
Original languageUndefined
Pages (from-to)11626-11635
JournalJournal of the American Chemical Society
Volume136
Issue number33
DOIs
Publication statusPublished - 2014

Keywords

  • METIS-306864
  • IR-94989

Cite this

Corani, A., Huijser, J. M., Gustavsson, T., Markovitsi, D., Malmqvist, P-A., Pezzella, A., ... Sundström, V. (2014). Superior photoprotective motifs and mechanisms in eumelanins uncovered. Journal of the American Chemical Society, 136(33), 11626-11635. https://doi.org/10.1021/ja501499q
Corani, Alice ; Huijser, Jannetje Maria ; Gustavsson, Thomas ; Markovitsi, Dimitra ; Malmqvist, Per-Ake ; Pezzella, Alessandro ; D'Ischia, Marco ; Sundström, Villy. / Superior photoprotective motifs and mechanisms in eumelanins uncovered. In: Journal of the American Chemical Society. 2014 ; Vol. 136, No. 33. pp. 11626-11635.
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abstract = "Human pigmentation is a complex phenomenon commonly believed to serve a photoprotective function through the generation and strategic localization of black insoluble eumelanin biopolymers in sun exposed areas of the body. Despite compelling biomedical relevance to skin cancer and melanoma, eumelanin photoprotection is still an enigma: What makes this pigment so efficient in dissipating the excess energy brought by harmful UV-light as heat? Why has Nature selected 5,6-dihydroxyindole-2-carboxylic acid (DHICA) as the major building block of the pigment instead of the decarboxylated derivative (DHI)? By using pico- and femtosecond fluorescence spectroscopy we demonstrate herein that the excited state deactivation in DHICA oligomers is 3 orders of magnitude faster compared to DHI oligomers. This drastic effect is attributed to their specific structural patterns enabling multiple pathways of intra- and interunit proton transfer. The discovery that DHICA-based scaffolds specifically confer uniquely robust photoprotective properties to natural eumelanins settles a fundamental gap in the biology of human pigmentation and opens the doorway to attractive advances and applications",
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Corani, A, Huijser, JM, Gustavsson, T, Markovitsi, D, Malmqvist, P-A, Pezzella, A, D'Ischia, M & Sundström, V 2014, 'Superior photoprotective motifs and mechanisms in eumelanins uncovered' Journal of the American Chemical Society, vol. 136, no. 33, pp. 11626-11635. https://doi.org/10.1021/ja501499q

Superior photoprotective motifs and mechanisms in eumelanins uncovered. / Corani, Alice; Huijser, Jannetje Maria; Gustavsson, Thomas; Markovitsi, Dimitra; Malmqvist, Per-Ake; Pezzella, Alessandro; D'Ischia, Marco; Sundström, Villy.

In: Journal of the American Chemical Society, Vol. 136, No. 33, 2014, p. 11626-11635.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Superior photoprotective motifs and mechanisms in eumelanins uncovered

AU - Corani, Alice

AU - Huijser, Jannetje Maria

AU - Gustavsson, Thomas

AU - Markovitsi, Dimitra

AU - Malmqvist, Per-Ake

AU - Pezzella, Alessandro

AU - D'Ischia, Marco

AU - Sundström, Villy

PY - 2014

Y1 - 2014

N2 - Human pigmentation is a complex phenomenon commonly believed to serve a photoprotective function through the generation and strategic localization of black insoluble eumelanin biopolymers in sun exposed areas of the body. Despite compelling biomedical relevance to skin cancer and melanoma, eumelanin photoprotection is still an enigma: What makes this pigment so efficient in dissipating the excess energy brought by harmful UV-light as heat? Why has Nature selected 5,6-dihydroxyindole-2-carboxylic acid (DHICA) as the major building block of the pigment instead of the decarboxylated derivative (DHI)? By using pico- and femtosecond fluorescence spectroscopy we demonstrate herein that the excited state deactivation in DHICA oligomers is 3 orders of magnitude faster compared to DHI oligomers. This drastic effect is attributed to their specific structural patterns enabling multiple pathways of intra- and interunit proton transfer. The discovery that DHICA-based scaffolds specifically confer uniquely robust photoprotective properties to natural eumelanins settles a fundamental gap in the biology of human pigmentation and opens the doorway to attractive advances and applications

AB - Human pigmentation is a complex phenomenon commonly believed to serve a photoprotective function through the generation and strategic localization of black insoluble eumelanin biopolymers in sun exposed areas of the body. Despite compelling biomedical relevance to skin cancer and melanoma, eumelanin photoprotection is still an enigma: What makes this pigment so efficient in dissipating the excess energy brought by harmful UV-light as heat? Why has Nature selected 5,6-dihydroxyindole-2-carboxylic acid (DHICA) as the major building block of the pigment instead of the decarboxylated derivative (DHI)? By using pico- and femtosecond fluorescence spectroscopy we demonstrate herein that the excited state deactivation in DHICA oligomers is 3 orders of magnitude faster compared to DHI oligomers. This drastic effect is attributed to their specific structural patterns enabling multiple pathways of intra- and interunit proton transfer. The discovery that DHICA-based scaffolds specifically confer uniquely robust photoprotective properties to natural eumelanins settles a fundamental gap in the biology of human pigmentation and opens the doorway to attractive advances and applications

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