Superselective arterial spin labeling applied for flow territory mapping in various cerebrovascular diseases

Michael Helle*, Susanne Rüfer, Matthias J.P. Van Osch, Arya Nabavi, Karsten Alfke, David G. Norris, Olav Jansen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)


In three example patients suffering from internal carotid artery occlusion, intracranial steno-occlusive disease, and symptomatic arteriovenous malformation (AVM), a new method named superselective pseudo-continuous arterial spin labeling (pCASL) was used in addition to clinical routine measurements. The capabilities of this method are demonstrated to gain important information in diagnosis, risk analysis, and treatment monitoring that are neither accessible by digital subtraction angiography nor by existing selective arterial spin labeling methods and thus to propose future applications in clinical routine. In all cases superselective pCASL enabled the assessment of tissue viability and of territorial brain perfusion at different levels starting from major brain feeding vessels to collateral circulation at the level of the Circle of Willis to even distal branching arteries. This made it possible to estimate the contribution of an extracranial-intracranial bypass to the brain perfusion; to depict individual arteries to important functional brain areas; to identify en-passant feeding vessels of an AVM and to track possible changes in their perfusion territories after intervention. © 2013 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)496-503
Number of pages8
JournalJournal of magnetic resonance imaging
Issue number2
Early online date22 Mar 2013
Publication statusPublished - Aug 2013
Externally publishedYes


  • arterial spin labeling
  • arteriovenous malformation
  • cerebrovascular disease
  • flow territories
  • perfusion
  • n/a OA procedure


Dive into the research topics of 'Superselective arterial spin labeling applied for flow territory mapping in various cerebrovascular diseases'. Together they form a unique fingerprint.

Cite this