Survival of adhering cortical neurons on polyethylenimine micropatterns

T.G. Ruardij, M.H. Goedbloed, Wim Rutten

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    Abstract

    The influence of neuron-adhesive pattern geometry on long-term survival of cortical neural tissue (rat brain) was studied over a time period of 15 days. Microwells (depth 0.5 /spl mu/m) with diameters of 25, 50, 100 and 150 /spl mu/m and inter-microwell distances of 15, 30, 60 and 90 /spl mu/m, were etched in a neuron-repellent fluorocarbon (FC)-layer and coated with neuron-adhesive polyethylenimine (PEI). Results showed that the survival of neural tissue was geometry-independent after 1, 4 and 8 days but was favored on 150 /spl mu/m wells after 15 days.
    Original languageUndefined
    Title of host publicationProceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Isyanbul, Turkey
    Place of PublicationPiscattaway, USA
    PublisherIEEE
    Pages-
    Number of pages4
    ISBN (Print)0-7803-7213-1
    Publication statusPublished - 25 Oct 2001
    Event23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2001 - Istanbul, Turkey
    Duration: 25 Oct 200128 Oct 2001
    Conference number: 23

    Publication series

    Name
    PublisherIEEE
    Volume1

    Conference

    Conference23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2001
    Abbreviated titleEMBC
    CountryTurkey
    CityIstanbul
    Period25/10/0128/10/01

    Keywords

    • METIS-200709
    • IR-42182

    Cite this

    Ruardij, T. G., Goedbloed, M. H., & Rutten, W. (2001). Survival of adhering cortical neurons on polyethylenimine micropatterns. In Proceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Isyanbul, Turkey (pp. -). Piscattaway, USA: IEEE.