Abstract
In DMF or acetonitrile with NaH as a base at room temperature the tetraalkylation of calix[4]arenes 1a and 1b proceeds via the syn-1,2-disubstituted products to the tetraalkylated calix[4]arenes in the cone conformation. With KH as a base the tetraalkylated calix[4]arenes are predominantly formed in the partial cone conformation, and the reaction proceeds via both the syn-1,3-di and the syn-1,2-disubstituted products. Also the solvent influences the pathway via which tetraalkylation takes place. The syn-1,2-disubstituted calix[4]arenes 4-6 can be isolated in 15-55 % from the NaH/DMF or MeCN reactions when only 2.2 equiv of the electrophile are used.
Original language | Undefined |
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Pages (from-to) | 2675-2678 |
Number of pages | 4 |
Journal | Tetrahedron letters |
Volume | 0 |
Issue number | 32 |
DOIs | |
Publication status | Published - 1991 |
Keywords
- METIS-106698
- IR-12508