Synchronization of the parkinsonian globus pallidus by gap junctions

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    38 Downloads (Pure)

    Abstract

    We introduce pallidal gap junctional coupling as a possible mechanism for synchronization of the GPe after dopamine depletion. In a confocal imaging study, we show the presence of the neural gap junction protein Cx36 in the human GPe, including a possible remodeling process in PD patients. Dopamine has been shown to down-regulate the conductance of gap junctions in different regions of the brain [2,3], making dopamine depletion a possible candidate for increased influence of gap junctional coupling in PD.
    Original languageUndefined
    Title of host publicationTwenty Third Annual Computational Neuroscience Meeting: CNS*2014
    Place of PublicationLondon
    PublisherBioMed Central Ltd.
    PagesO17
    Number of pages1
    ISBN (Print)1471-2202
    DOIs
    Publication statusPublished - 2014

    Publication series

    NameBMC Neuroscience
    PublisherBiomed Central
    Volume15 (Suppl. 1)
    ISSN (Print)1471-2202

    Keywords

    • EWI-24963
    • IR-91589
    • METIS-305974

    Cite this

    Schwab, B. C., Meijer, H. G. E., van Wezel, R. J. A., & van Gils, S. A. (2014). Synchronization of the parkinsonian globus pallidus by gap junctions. In Twenty Third Annual Computational Neuroscience Meeting: CNS*2014 (pp. O17). (BMC Neuroscience; Vol. 15 (Suppl. 1)). London: BioMed Central Ltd.. https://doi.org/10.1186/1471-2202-15-S1-O17
    Schwab, B.C. ; Meijer, Hil Gaétan Ellart ; van Wezel, Richard Jack Anton ; van Gils, Stephanus A. / Synchronization of the parkinsonian globus pallidus by gap junctions. Twenty Third Annual Computational Neuroscience Meeting: CNS*2014. London : BioMed Central Ltd., 2014. pp. O17 (BMC Neuroscience).
    @inproceedings{4a4005cada574610aca875670036336f,
    title = "Synchronization of the parkinsonian globus pallidus by gap junctions",
    abstract = "We introduce pallidal gap junctional coupling as a possible mechanism for synchronization of the GPe after dopamine depletion. In a confocal imaging study, we show the presence of the neural gap junction protein Cx36 in the human GPe, including a possible remodeling process in PD patients. Dopamine has been shown to down-regulate the conductance of gap junctions in different regions of the brain [2,3], making dopamine depletion a possible candidate for increased influence of gap junctional coupling in PD.",
    keywords = "EWI-24963, IR-91589, METIS-305974",
    author = "B.C. Schwab and Meijer, {Hil Ga{\'e}tan Ellart} and {van Wezel}, {Richard Jack Anton} and {van Gils}, {Stephanus A.}",
    note = "10.1186/1471-2202-15-S1-O17",
    year = "2014",
    doi = "10.1186/1471-2202-15-S1-O17",
    language = "Undefined",
    isbn = "1471-2202",
    series = "BMC Neuroscience",
    publisher = "BioMed Central Ltd.",
    pages = "O17",
    booktitle = "Twenty Third Annual Computational Neuroscience Meeting: CNS*2014",
    address = "United Kingdom",

    }

    Schwab, BC, Meijer, HGE, van Wezel, RJA & van Gils, SA 2014, Synchronization of the parkinsonian globus pallidus by gap junctions. in Twenty Third Annual Computational Neuroscience Meeting: CNS*2014. BMC Neuroscience, vol. 15 (Suppl. 1), BioMed Central Ltd., London, pp. O17. https://doi.org/10.1186/1471-2202-15-S1-O17

    Synchronization of the parkinsonian globus pallidus by gap junctions. / Schwab, B.C.; Meijer, Hil Gaétan Ellart; van Wezel, Richard Jack Anton; van Gils, Stephanus A.

    Twenty Third Annual Computational Neuroscience Meeting: CNS*2014. London : BioMed Central Ltd., 2014. p. O17 (BMC Neuroscience; Vol. 15 (Suppl. 1)).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    TY - GEN

    T1 - Synchronization of the parkinsonian globus pallidus by gap junctions

    AU - Schwab, B.C.

    AU - Meijer, Hil Gaétan Ellart

    AU - van Wezel, Richard Jack Anton

    AU - van Gils, Stephanus A.

    N1 - 10.1186/1471-2202-15-S1-O17

    PY - 2014

    Y1 - 2014

    N2 - We introduce pallidal gap junctional coupling as a possible mechanism for synchronization of the GPe after dopamine depletion. In a confocal imaging study, we show the presence of the neural gap junction protein Cx36 in the human GPe, including a possible remodeling process in PD patients. Dopamine has been shown to down-regulate the conductance of gap junctions in different regions of the brain [2,3], making dopamine depletion a possible candidate for increased influence of gap junctional coupling in PD.

    AB - We introduce pallidal gap junctional coupling as a possible mechanism for synchronization of the GPe after dopamine depletion. In a confocal imaging study, we show the presence of the neural gap junction protein Cx36 in the human GPe, including a possible remodeling process in PD patients. Dopamine has been shown to down-regulate the conductance of gap junctions in different regions of the brain [2,3], making dopamine depletion a possible candidate for increased influence of gap junctional coupling in PD.

    KW - EWI-24963

    KW - IR-91589

    KW - METIS-305974

    U2 - 10.1186/1471-2202-15-S1-O17

    DO - 10.1186/1471-2202-15-S1-O17

    M3 - Conference contribution

    SN - 1471-2202

    T3 - BMC Neuroscience

    SP - O17

    BT - Twenty Third Annual Computational Neuroscience Meeting: CNS*2014

    PB - BioMed Central Ltd.

    CY - London

    ER -

    Schwab BC, Meijer HGE, van Wezel RJA, van Gils SA. Synchronization of the parkinsonian globus pallidus by gap junctions. In Twenty Third Annual Computational Neuroscience Meeting: CNS*2014. London: BioMed Central Ltd. 2014. p. O17. (BMC Neuroscience). https://doi.org/10.1186/1471-2202-15-S1-O17