Synchronization of the parkinsonian globus pallidus by gap junctions

B.C. Schwab; Hil Gaétan Ellart Meijer; Richard Jack Anton van Wezel; Stephanus A. van Gils

doi:10.1186/1471-2202-15-S1-O17

Synchronization of the parkinsonian globus pallidus by gap junctions

B.C. Schwab, Hil Gaétan Ellart Meijer, Richard Jack Anton van Wezel, Stephanus A. van Gils

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

We introduce pallidal gap junctional coupling as a possible mechanism for synchronization of the GPe after dopamine depletion. In a confocal imaging study, we show the presence of the neural gap junction protein Cx36 in the human GPe, including a possible remodeling process in PD patients. Dopamine has been shown to down-regulate the conductance of gap junctions in different regions of the brain [2,3], making dopamine depletion a possible candidate for increased influence of gap junctional coupling in PD.

Original language	Undefined
Title of host publication	Twenty Third Annual Computational Neuroscience Meeting: CNS*2014
Place of Publication	London
Publisher	BioMed Central
Pages	O17
Number of pages	1
ISBN (Print)	1471-2202
DOIs	https://doi.org/10.1186/1471-2202-15-S1-O17
Publication status	Published - 2014
Event	23rd Annual Computational Neuroscience Meeting, CNS 2014 - Québec, Canada Duration: 26 Jul 2014 → 31 Jul 2014

Publication series

Name	BMC Neuroscience
Publisher	Biomed Central
Volume	15 (Suppl. 1)
ISSN (Print)	1471-2202

Conference

Conference	23rd Annual Computational Neuroscience Meeting, CNS 2014
Period	26/07/14 → 31/07/14
Other	26-31 July 2014

Keywords

EWI-24963
IR-91589
METIS-305974

Access to Document

10.1186/1471-2202-15-S1-O17

schwab14CNS

http://eprints.eemcs.utwente.nl/secure2/24963/01/schwab14CNS.pdf

Cite this

@inproceedings{4a4005cada574610aca875670036336f,

title = "Synchronization of the parkinsonian globus pallidus by gap junctions",

abstract = "We introduce pallidal gap junctional coupling as a possible mechanism for synchronization of the GPe after dopamine depletion. In a confocal imaging study, we show the presence of the neural gap junction protein Cx36 in the human GPe, including a possible remodeling process in PD patients. Dopamine has been shown to down-regulate the conductance of gap junctions in different regions of the brain [2,3], making dopamine depletion a possible candidate for increased influence of gap junctional coupling in PD.",

keywords = "EWI-24963, IR-91589, METIS-305974",

author = "B.C. Schwab and Meijer, {Hil Ga{\'e}tan Ellart} and {van Wezel}, {Richard Jack Anton} and {van Gils}, {Stephanus A.}",

note = "10.1186/1471-2202-15-S1-O17 ; 23rd Annual Computational Neuroscience Meeting, CNS 2014 ; Conference date: 26-07-2014 Through 31-07-2014",

year = "2014",

doi = "10.1186/1471-2202-15-S1-O17",

language = "Undefined",

isbn = "1471-2202",

series = "BMC Neuroscience",

publisher = "BioMed Central",

pages = "O17",

booktitle = "Twenty Third Annual Computational Neuroscience Meeting: CNS*2014",

address = "United Kingdom",

}

Schwab, BC , Meijer, HGE , van Wezel, RJA & van Gils, SA 2014, Synchronization of the parkinsonian globus pallidus by gap junctions. in Twenty Third Annual Computational Neuroscience Meeting: CNS*2014. BMC Neuroscience, vol. 15 (Suppl. 1), BioMed Central, London, pp. O17, 23rd Annual Computational Neuroscience Meeting, CNS 2014, 26/07/14. https://doi.org/10.1186/1471-2202-15-S1-O17

Synchronization of the parkinsonian globus pallidus by gap junctions. / Schwab, B.C.; Meijer, Hil Gaétan Ellart ; van Wezel, Richard Jack Anton et al.
Twenty Third Annual Computational Neuroscience Meeting: CNS*2014. London: BioMed Central, 2014. p. O17 (BMC Neuroscience; Vol. 15 (Suppl. 1)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

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AU - Schwab, B.C.

AU - Meijer, Hil Gaétan Ellart

AU - van Wezel, Richard Jack Anton

AU - van Gils, Stephanus A.

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AB - We introduce pallidal gap junctional coupling as a possible mechanism for synchronization of the GPe after dopamine depletion. In a confocal imaging study, we show the presence of the neural gap junction protein Cx36 in the human GPe, including a possible remodeling process in PD patients. Dopamine has been shown to down-regulate the conductance of gap junctions in different regions of the brain [2,3], making dopamine depletion a possible candidate for increased influence of gap junctional coupling in PD.

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