We introduce pallidal gap junctional coupling as a possible mechanism for synchronization of the GPe after dopamine depletion. In a confocal imaging study, we show the presence of the neural gap junction protein Cx36 in the human GPe, including a possible remodeling process in PD patients. Dopamine has been shown to down-regulate the conductance of gap junctions in different regions of the brain [2,3], making dopamine depletion a possible candidate for increased influence of gap junctional coupling in PD.
|Volume||15 (Suppl. 1)|
|Conference||23rd Annual Computational Neuroscience Meeting, CNS 2014|
|Period||26/07/14 → 31/07/14|
|Other||26-31 July 2014|