Synchronization of the parkinsonian globus pallidus by gap junctions

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    Abstract

    We introduce pallidal gap junctional coupling as a possible mechanism for synchronization of the GPe after dopamine depletion. In a confocal imaging study, we show the presence of the neural gap junction protein Cx36 in the human GPe, including a possible remodeling process in PD patients. Dopamine has been shown to down-regulate the conductance of gap junctions in different regions of the brain [2,3], making dopamine depletion a possible candidate for increased influence of gap junctional coupling in PD.
    Original languageUndefined
    Title of host publicationTwenty Third Annual Computational Neuroscience Meeting: CNS*2014
    Place of PublicationLondon
    PublisherBioMed Central Ltd.
    PagesO17
    Number of pages1
    ISBN (Print)1471-2202
    DOIs
    Publication statusPublished - 2014
    Event23rd Annual Computational Neuroscience Meeting, CNS 2014 - Québec, Canada
    Duration: 26 Jul 201431 Jul 2014

    Publication series

    NameBMC Neuroscience
    PublisherBiomed Central
    Volume15 (Suppl. 1)
    ISSN (Print)1471-2202

    Conference

    Conference23rd Annual Computational Neuroscience Meeting, CNS 2014
    Period26/07/1431/07/14
    Other26-31 July 2014

    Keywords

    • EWI-24963
    • IR-91589
    • METIS-305974

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