Synchronization of the parkinsonian globus pallidus by gap junctions

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Abstract

We introduce pallidal gap junctional coupling as a possible mechanism for synchronization of the GPe after dopamine depletion. In a confocal imaging study, we show the presence of the neural gap junction protein Cx36 in the human GPe, including a possible remodeling process in PD patients. Dopamine has been shown to down-regulate the conductance of gap junctions in different regions of the brain [2,3], making dopamine depletion a possible candidate for increased influence of gap junctional coupling in PD.
Original languageUndefined
Title of host publicationTwenty Third Annual Computational Neuroscience Meeting: CNS*2014
Place of PublicationLondon
PublisherBioMed Central Ltd.
PagesO17
Number of pages1
ISBN (Print)1471-2202
DOIs
Publication statusPublished - 2014

Publication series

NameBMC Neuroscience
PublisherBiomed Central
Volume15 (Suppl. 1)
ISSN (Print)1471-2202

Keywords

  • EWI-24963
  • IR-91589
  • METIS-305974

Cite this

Schwab, B. C., Meijer, H. G. E., van Wezel, R. J. A., & van Gils, S. A. (2014). Synchronization of the parkinsonian globus pallidus by gap junctions. In Twenty Third Annual Computational Neuroscience Meeting: CNS*2014 (pp. O17). (BMC Neuroscience; Vol. 15 (Suppl. 1)). London: BioMed Central Ltd.. https://doi.org/10.1186/1471-2202-15-S1-O17
Schwab, B.C. ; Meijer, Hil Gaétan Ellart ; van Wezel, Richard Jack Anton ; van Gils, Stephanus A. / Synchronization of the parkinsonian globus pallidus by gap junctions. Twenty Third Annual Computational Neuroscience Meeting: CNS*2014. London : BioMed Central Ltd., 2014. pp. O17 (BMC Neuroscience).
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abstract = "We introduce pallidal gap junctional coupling as a possible mechanism for synchronization of the GPe after dopamine depletion. In a confocal imaging study, we show the presence of the neural gap junction protein Cx36 in the human GPe, including a possible remodeling process in PD patients. Dopamine has been shown to down-regulate the conductance of gap junctions in different regions of the brain [2,3], making dopamine depletion a possible candidate for increased influence of gap junctional coupling in PD.",
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Schwab, BC, Meijer, HGE, van Wezel, RJA & van Gils, SA 2014, Synchronization of the parkinsonian globus pallidus by gap junctions. in Twenty Third Annual Computational Neuroscience Meeting: CNS*2014. BMC Neuroscience, vol. 15 (Suppl. 1), BioMed Central Ltd., London, pp. O17. https://doi.org/10.1186/1471-2202-15-S1-O17

Synchronization of the parkinsonian globus pallidus by gap junctions. / Schwab, B.C.; Meijer, Hil Gaétan Ellart; van Wezel, Richard Jack Anton; van Gils, Stephanus A.

Twenty Third Annual Computational Neuroscience Meeting: CNS*2014. London : BioMed Central Ltd., 2014. p. O17 (BMC Neuroscience; Vol. 15 (Suppl. 1)).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

TY - GEN

T1 - Synchronization of the parkinsonian globus pallidus by gap junctions

AU - Schwab, B.C.

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AU - van Gils, Stephanus A.

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AB - We introduce pallidal gap junctional coupling as a possible mechanism for synchronization of the GPe after dopamine depletion. In a confocal imaging study, we show the presence of the neural gap junction protein Cx36 in the human GPe, including a possible remodeling process in PD patients. Dopamine has been shown to down-regulate the conductance of gap junctions in different regions of the brain [2,3], making dopamine depletion a possible candidate for increased influence of gap junctional coupling in PD.

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Schwab BC, Meijer HGE, van Wezel RJA, van Gils SA. Synchronization of the parkinsonian globus pallidus by gap junctions. In Twenty Third Annual Computational Neuroscience Meeting: CNS*2014. London: BioMed Central Ltd. 2014. p. O17. (BMC Neuroscience). https://doi.org/10.1186/1471-2202-15-S1-O17