Synchronization of the parkinsonian globus pallidus by gap junctions

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    Abstract

    We introduce pallidal gap junctional coupling as a possible mechanism for synchronization of the GPe after dopamine depletion. In a confocal imaging study, we show the presence of the neural gap junction protein Cx36 in the human GPe, including a possible remodeling process in PD patients. Dopamine has been shown to down-regulate the conductance of gap junctions in different regions of the brain [2,3], making dopamine depletion a possible candidate for increased influence of gap junctional coupling in PD.
    Original languageUndefined
    Title of host publicationTwenty Third Annual Computational Neuroscience Meeting: CNS*2014
    Place of PublicationLondon
    PublisherBioMed Central Ltd.
    PagesO17
    Number of pages1
    ISBN (Print)1471-2202
    DOIs
    Publication statusPublished - 2014

    Publication series

    NameBMC Neuroscience
    PublisherBiomed Central
    Volume15 (Suppl. 1)
    ISSN (Print)1471-2202

    Keywords

    • EWI-24963
    • IR-91589
    • METIS-305974

    Cite this

    Schwab, B. C., Meijer, H. G. E., van Wezel, R. J. A., & van Gils, S. A. (2014). Synchronization of the parkinsonian globus pallidus by gap junctions. In Twenty Third Annual Computational Neuroscience Meeting: CNS*2014 (pp. O17). (BMC Neuroscience; Vol. 15 (Suppl. 1)). London: BioMed Central Ltd.. https://doi.org/10.1186/1471-2202-15-S1-O17