Synchrony in Parkinson’s disease: importance of intrinsic properties of the external globus pallidus

H. Bergman (Editor), B.C. Schwab, Tjitske Heida, Yan Zhao, Enrico Marani, Stephanus A. van Gils, Richard Jack Anton van Wezel

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Abstract

The mechanisms for the emergence and transmission of synchronized oscillations in Parkinson’s disease, which are potentially causal to motor deficits, remain debated. Aside from the motor cortex and the subthalamic nucleus, the external globus pallidus (GPe) has been shown to be essential for the maintenance of these oscillations and plays a major role in sculpting neural network activity in the basal ganglia (BG). While neural activity of the healthy GPe shows almost no correlations between pairs of neurons, prominent synchronization in the β frequency band arises after dopamine depletion. Several studies have proposed that this shift is due to network interactions between the different BG nuclei, including the GPe. However, recent studies demonstrate an important role for the properties of neurons within the GPe. In this review, we will discuss these intrinsic GPe properties and review proposed mechanisms for activity decorrelation within the dopamine-intact GPe. Failure of the GPe to desynchronize correlated inputs can be a possible explanation for synchronization in the whole BG. Potential triggers of synchronization involve the enhancement of GPe-GPe inhibition and changes in ion channel function in GPe neurons.
Original languageUndefined
Pages (from-to)1-7
Number of pages7
JournalFrontiers in systems neuroscience
Volume7
Issue number60
DOIs
Publication statusPublished - 4 Oct 2013

Keywords

  • GPe-GPe synapses
  • Dopamine Depletion
  • NaF Channels
  • HCN Channels
  • External Globus Pallidus
  • Desynchronization
  • Plasticity
  • EWI-23693
  • METIS-302538
  • IR-87380
  • SK Channels

Cite this

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title = "Synchrony in Parkinson’s disease: importance of intrinsic properties of the external globus pallidus",
abstract = "The mechanisms for the emergence and transmission of synchronized oscillations in Parkinson’s disease, which are potentially causal to motor deficits, remain debated. Aside from the motor cortex and the subthalamic nucleus, the external globus pallidus (GPe) has been shown to be essential for the maintenance of these oscillations and plays a major role in sculpting neural network activity in the basal ganglia (BG). While neural activity of the healthy GPe shows almost no correlations between pairs of neurons, prominent synchronization in the β frequency band arises after dopamine depletion. Several studies have proposed that this shift is due to network interactions between the different BG nuclei, including the GPe. However, recent studies demonstrate an important role for the properties of neurons within the GPe. In this review, we will discuss these intrinsic GPe properties and review proposed mechanisms for activity decorrelation within the dopamine-intact GPe. Failure of the GPe to desynchronize correlated inputs can be a possible explanation for synchronization in the whole BG. Potential triggers of synchronization involve the enhancement of GPe-GPe inhibition and changes in ion channel function in GPe neurons.",
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Synchrony in Parkinson’s disease: importance of intrinsic properties of the external globus pallidus. / Bergman, H. (Editor); Schwab, B.C.; Heida, Tjitske; Zhao, Yan; Marani, Enrico; van Gils, Stephanus A.; van Wezel, Richard Jack Anton.

In: Frontiers in systems neuroscience, Vol. 7, No. 60, 04.10.2013, p. 1-7.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Synchrony in Parkinson’s disease: importance of intrinsic properties of the external globus pallidus

AU - Schwab, B.C.

AU - Heida, Tjitske

AU - Zhao, Yan

AU - Marani, Enrico

AU - van Gils, Stephanus A.

AU - van Wezel, Richard Jack Anton

A2 - Bergman, H.

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N2 - The mechanisms for the emergence and transmission of synchronized oscillations in Parkinson’s disease, which are potentially causal to motor deficits, remain debated. Aside from the motor cortex and the subthalamic nucleus, the external globus pallidus (GPe) has been shown to be essential for the maintenance of these oscillations and plays a major role in sculpting neural network activity in the basal ganglia (BG). While neural activity of the healthy GPe shows almost no correlations between pairs of neurons, prominent synchronization in the β frequency band arises after dopamine depletion. Several studies have proposed that this shift is due to network interactions between the different BG nuclei, including the GPe. However, recent studies demonstrate an important role for the properties of neurons within the GPe. In this review, we will discuss these intrinsic GPe properties and review proposed mechanisms for activity decorrelation within the dopamine-intact GPe. Failure of the GPe to desynchronize correlated inputs can be a possible explanation for synchronization in the whole BG. Potential triggers of synchronization involve the enhancement of GPe-GPe inhibition and changes in ion channel function in GPe neurons.

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KW - METIS-302538

KW - IR-87380

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