Synchrony in Parkinson’s disease: importance of intrinsic properties of the external globus pallidus

H. Bergman (Editor), B.C. Schwab, Tjitske Heida, Yan Zhao, Enrico Marani, Stephanus A. van Gils, Richard Jack Anton van Wezel

    Research output: Contribution to journalArticleAcademicpeer-review

    14 Citations (Scopus)

    Abstract

    The mechanisms for the emergence and transmission of synchronized oscillations in Parkinson’s disease, which are potentially causal to motor deficits, remain debated. Aside from the motor cortex and the subthalamic nucleus, the external globus pallidus (GPe) has been shown to be essential for the maintenance of these oscillations and plays a major role in sculpting neural network activity in the basal ganglia (BG). While neural activity of the healthy GPe shows almost no correlations between pairs of neurons, prominent synchronization in the β frequency band arises after dopamine depletion. Several studies have proposed that this shift is due to network interactions between the different BG nuclei, including the GPe. However, recent studies demonstrate an important role for the properties of neurons within the GPe. In this review, we will discuss these intrinsic GPe properties and review proposed mechanisms for activity decorrelation within the dopamine-intact GPe. Failure of the GPe to desynchronize correlated inputs can be a possible explanation for synchronization in the whole BG. Potential triggers of synchronization involve the enhancement of GPe-GPe inhibition and changes in ion channel function in GPe neurons.
    Original languageUndefined
    Pages (from-to)1-7
    Number of pages7
    JournalFrontiers in systems neuroscience
    Volume7
    Issue number60
    DOIs
    Publication statusPublished - 4 Oct 2013

    Keywords

    • GPe-GPe synapses
    • Dopamine Depletion
    • NaF Channels
    • HCN Channels
    • External Globus Pallidus
    • Desynchronization
    • Plasticity
    • EWI-23693
    • METIS-302538
    • IR-87380
    • SK Channels

    Cite this

    @article{1f599e95a2fe49f6b7280a3b952e795c,
    title = "Synchrony in Parkinson’s disease: importance of intrinsic properties of the external globus pallidus",
    abstract = "The mechanisms for the emergence and transmission of synchronized oscillations in Parkinson’s disease, which are potentially causal to motor deficits, remain debated. Aside from the motor cortex and the subthalamic nucleus, the external globus pallidus (GPe) has been shown to be essential for the maintenance of these oscillations and plays a major role in sculpting neural network activity in the basal ganglia (BG). While neural activity of the healthy GPe shows almost no correlations between pairs of neurons, prominent synchronization in the β frequency band arises after dopamine depletion. Several studies have proposed that this shift is due to network interactions between the different BG nuclei, including the GPe. However, recent studies demonstrate an important role for the properties of neurons within the GPe. In this review, we will discuss these intrinsic GPe properties and review proposed mechanisms for activity decorrelation within the dopamine-intact GPe. Failure of the GPe to desynchronize correlated inputs can be a possible explanation for synchronization in the whole BG. Potential triggers of synchronization involve the enhancement of GPe-GPe inhibition and changes in ion channel function in GPe neurons.",
    keywords = "GPe-GPe synapses, Dopamine Depletion, NaF Channels, HCN Channels, External Globus Pallidus, Desynchronization, Plasticity, EWI-23693, METIS-302538, IR-87380, SK Channels",
    author = "H. Bergman and B.C. Schwab and Tjitske Heida and Yan Zhao and Enrico Marani and {van Gils}, {Stephanus A.} and {van Wezel}, {Richard Jack Anton}",
    note = "eemcs-eprint-23693",
    year = "2013",
    month = "10",
    day = "4",
    doi = "10.3389/fnsys.2013.00060",
    language = "Undefined",
    volume = "7",
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    Synchrony in Parkinson’s disease: importance of intrinsic properties of the external globus pallidus. / Bergman, H. (Editor); Schwab, B.C.; Heida, Tjitske; Zhao, Yan; Marani, Enrico; van Gils, Stephanus A.; van Wezel, Richard Jack Anton.

    In: Frontiers in systems neuroscience, Vol. 7, No. 60, 04.10.2013, p. 1-7.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Synchrony in Parkinson’s disease: importance of intrinsic properties of the external globus pallidus

    AU - Schwab, B.C.

    AU - Heida, Tjitske

    AU - Zhao, Yan

    AU - Marani, Enrico

    AU - van Gils, Stephanus A.

    AU - van Wezel, Richard Jack Anton

    A2 - Bergman, H.

    N1 - eemcs-eprint-23693

    PY - 2013/10/4

    Y1 - 2013/10/4

    N2 - The mechanisms for the emergence and transmission of synchronized oscillations in Parkinson’s disease, which are potentially causal to motor deficits, remain debated. Aside from the motor cortex and the subthalamic nucleus, the external globus pallidus (GPe) has been shown to be essential for the maintenance of these oscillations and plays a major role in sculpting neural network activity in the basal ganglia (BG). While neural activity of the healthy GPe shows almost no correlations between pairs of neurons, prominent synchronization in the β frequency band arises after dopamine depletion. Several studies have proposed that this shift is due to network interactions between the different BG nuclei, including the GPe. However, recent studies demonstrate an important role for the properties of neurons within the GPe. In this review, we will discuss these intrinsic GPe properties and review proposed mechanisms for activity decorrelation within the dopamine-intact GPe. Failure of the GPe to desynchronize correlated inputs can be a possible explanation for synchronization in the whole BG. Potential triggers of synchronization involve the enhancement of GPe-GPe inhibition and changes in ion channel function in GPe neurons.

    AB - The mechanisms for the emergence and transmission of synchronized oscillations in Parkinson’s disease, which are potentially causal to motor deficits, remain debated. Aside from the motor cortex and the subthalamic nucleus, the external globus pallidus (GPe) has been shown to be essential for the maintenance of these oscillations and plays a major role in sculpting neural network activity in the basal ganglia (BG). While neural activity of the healthy GPe shows almost no correlations between pairs of neurons, prominent synchronization in the β frequency band arises after dopamine depletion. Several studies have proposed that this shift is due to network interactions between the different BG nuclei, including the GPe. However, recent studies demonstrate an important role for the properties of neurons within the GPe. In this review, we will discuss these intrinsic GPe properties and review proposed mechanisms for activity decorrelation within the dopamine-intact GPe. Failure of the GPe to desynchronize correlated inputs can be a possible explanation for synchronization in the whole BG. Potential triggers of synchronization involve the enhancement of GPe-GPe inhibition and changes in ion channel function in GPe neurons.

    KW - GPe-GPe synapses

    KW - Dopamine Depletion

    KW - NaF Channels

    KW - HCN Channels

    KW - External Globus Pallidus

    KW - Desynchronization

    KW - Plasticity

    KW - EWI-23693

    KW - METIS-302538

    KW - IR-87380

    KW - SK Channels

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    DO - 10.3389/fnsys.2013.00060

    M3 - Article

    VL - 7

    SP - 1

    EP - 7

    JO - Frontiers in systems neuroscience

    JF - Frontiers in systems neuroscience

    SN - 1662-5137

    IS - 60

    ER -