Synthesis and aqueous phase behavior of thermoresponsive biodegradable poly(D,L-3-methylglycolide)-block-poly(ethyelene glycol)-block-poly(D,L-3-methylglycolide) triblock copolymers

Zhiyuan Zhong, Pieter J. Dijkstra, Jan Feijen, Young-Min Kwon, You Han Bae, Sung Wan Kim

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)

Abstract

Novel biodegradable thermosensitive triblock copolymers of poly(D,L-3-methylglycolide)-block-poly(ethylene glycol)-block-poly(D,L-3-methylglycolide) (PMG-PEG-PMG) have been synthesized. Ring-opening polymerization of D,L-3-methyl-glycolide (MG) initiated with poly(ethylene glycol) (PEG) and Ca[N(SiMe3)2]2(THF)2 provided triblock copolymers with alternating lactyl/glycolyl sequences of controlled molecular weight, low polydispersity index and uniform chain structure. At relatively low temperatures (≈10 °C) these copolymers formed clear solutions in water up to high concentrations (50 wt.-%). Depending on molecular mass ratios of PMG and PEG blocks, a sol-gel transition or an increase in viscosity without gel formation was observed upon increasing the temperature of the aqueous solutions. The temperature-induced gelation was ascertained by rheology and dynamic differential scanning calorimetry (DDSC).
Original languageUndefined
Pages (from-to)1797-1803
JournalMacromolecular chemistry and physics
Volume203
Issue number12
DOIs
Publication statusPublished - 2002

Keywords

  • sol-gel transition
  • METIS-210931
  • IR-71846
  • Biodegradable
  • Block copolymers
  • Ring-opening polymerization
  • stimuli-sensitive polymers

Cite this

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title = "Synthesis and aqueous phase behavior of thermoresponsive biodegradable poly(D,L-3-methylglycolide)-block-poly(ethyelene glycol)-block-poly(D,L-3-methylglycolide) triblock copolymers",
abstract = "Novel biodegradable thermosensitive triblock copolymers of poly(D,L-3-methylglycolide)-block-poly(ethylene glycol)-block-poly(D,L-3-methylglycolide) (PMG-PEG-PMG) have been synthesized. Ring-opening polymerization of D,L-3-methyl-glycolide (MG) initiated with poly(ethylene glycol) (PEG) and Ca[N(SiMe3)2]2(THF)2 provided triblock copolymers with alternating lactyl/glycolyl sequences of controlled molecular weight, low polydispersity index and uniform chain structure. At relatively low temperatures (≈10 °C) these copolymers formed clear solutions in water up to high concentrations (50 wt.-{\%}). Depending on molecular mass ratios of PMG and PEG blocks, a sol-gel transition or an increase in viscosity without gel formation was observed upon increasing the temperature of the aqueous solutions. The temperature-induced gelation was ascertained by rheology and dynamic differential scanning calorimetry (DDSC).",
keywords = "sol-gel transition, METIS-210931, IR-71846, Biodegradable, Block copolymers, Ring-opening polymerization, stimuli-sensitive polymers",
author = "Zhiyuan Zhong and Dijkstra, {Pieter J.} and Jan Feijen and Young-Min Kwon and Bae, {You Han} and Kim, {Sung Wan}",
year = "2002",
doi = "10.1002/1521-3935(200208)203:12<1797::AID-MACP1797>3.0.CO;2-A",
language = "Undefined",
volume = "203",
pages = "1797--1803",
journal = "Macromolecular chemistry and physics",
issn = "1022-1352",
publisher = "Wiley-VCH Verlag",
number = "12",

}

Synthesis and aqueous phase behavior of thermoresponsive biodegradable poly(D,L-3-methylglycolide)-block-poly(ethyelene glycol)-block-poly(D,L-3-methylglycolide) triblock copolymers. / Zhong, Zhiyuan; Dijkstra, Pieter J.; Feijen, Jan; Kwon, Young-Min; Bae, You Han; Kim, Sung Wan.

In: Macromolecular chemistry and physics, Vol. 203, No. 12, 2002, p. 1797-1803.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Synthesis and aqueous phase behavior of thermoresponsive biodegradable poly(D,L-3-methylglycolide)-block-poly(ethyelene glycol)-block-poly(D,L-3-methylglycolide) triblock copolymers

AU - Zhong, Zhiyuan

AU - Dijkstra, Pieter J.

AU - Feijen, Jan

AU - Kwon, Young-Min

AU - Bae, You Han

AU - Kim, Sung Wan

PY - 2002

Y1 - 2002

N2 - Novel biodegradable thermosensitive triblock copolymers of poly(D,L-3-methylglycolide)-block-poly(ethylene glycol)-block-poly(D,L-3-methylglycolide) (PMG-PEG-PMG) have been synthesized. Ring-opening polymerization of D,L-3-methyl-glycolide (MG) initiated with poly(ethylene glycol) (PEG) and Ca[N(SiMe3)2]2(THF)2 provided triblock copolymers with alternating lactyl/glycolyl sequences of controlled molecular weight, low polydispersity index and uniform chain structure. At relatively low temperatures (≈10 °C) these copolymers formed clear solutions in water up to high concentrations (50 wt.-%). Depending on molecular mass ratios of PMG and PEG blocks, a sol-gel transition or an increase in viscosity without gel formation was observed upon increasing the temperature of the aqueous solutions. The temperature-induced gelation was ascertained by rheology and dynamic differential scanning calorimetry (DDSC).

AB - Novel biodegradable thermosensitive triblock copolymers of poly(D,L-3-methylglycolide)-block-poly(ethylene glycol)-block-poly(D,L-3-methylglycolide) (PMG-PEG-PMG) have been synthesized. Ring-opening polymerization of D,L-3-methyl-glycolide (MG) initiated with poly(ethylene glycol) (PEG) and Ca[N(SiMe3)2]2(THF)2 provided triblock copolymers with alternating lactyl/glycolyl sequences of controlled molecular weight, low polydispersity index and uniform chain structure. At relatively low temperatures (≈10 °C) these copolymers formed clear solutions in water up to high concentrations (50 wt.-%). Depending on molecular mass ratios of PMG and PEG blocks, a sol-gel transition or an increase in viscosity without gel formation was observed upon increasing the temperature of the aqueous solutions. The temperature-induced gelation was ascertained by rheology and dynamic differential scanning calorimetry (DDSC).

KW - sol-gel transition

KW - METIS-210931

KW - IR-71846

KW - Biodegradable

KW - Block copolymers

KW - Ring-opening polymerization

KW - stimuli-sensitive polymers

U2 - 10.1002/1521-3935(200208)203:12<1797::AID-MACP1797>3.0.CO;2-A

DO - 10.1002/1521-3935(200208)203:12<1797::AID-MACP1797>3.0.CO;2-A

M3 - Article

VL - 203

SP - 1797

EP - 1803

JO - Macromolecular chemistry and physics

JF - Macromolecular chemistry and physics

SN - 1022-1352

IS - 12

ER -