Synthesis and Characterization of hydrogen-bonded assemblies: toward the generation of binding site diversity

David N. Reinhoudt; P. Timmerman; F. Cardullo; M. Crego-Calama

doi:10.1007/978-94-011-4554-1_10

Synthesis and Characterization of hydrogen-bonded assemblies: toward the generation of binding site diversity

David N. Reinhoudt, P. Timmerman, F. Cardullo, M. Crego-Calama

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

Abstract

Discrete assemblies of nano-size dimensions were synthesized by non-covalent chemistry. Calix[4]arenes, diametrically substituted at the upper rim with two melamine units, form stable box-like assemblies in solution in the presence of two equivalents of 5,5-diethylbarbituric acid (DEB). Various techniques, such as NMR spectroscopy, MALDI-TOF mass spectrometry, and X-rays crystallography have been used for the characterization of these assemblies held together by 36 hydrogen bonds. Furthermore, assemblies with different types of functionalities at the upper rim of the calix[4]arene and at the melamine units were prepared. The effect of these functional groups on the stability of the assembly has been investigated. Small libraries of functionalized assemblies were formed by mixing the individual components under thermodynamically controlled conditions. This strategy provides access to functional group diversity.

Original language	English
Title of host publication	Supramolecular Science
Subtitle of host publication	Where It Is and Where It Is Going
Editors	Rocco Ungaro, Enrico Dalcanale
Place of Publication	Dordrecht
Publisher	Kluwer Academic Publishers
Pages	181-195
ISBN (Electronic)	978-94-011-4554-1
ISBN (Print)	978-0-7923-5656-1, 978-94-010-5933-6
DOIs	https://doi.org/10.1007/978-94-011-4554-1_10
Publication status	Published - 1999

Publication series

Name	Nato Science Series C
Publisher	Springer
Volume	527
ISSN (Print)	1389-2185

Access to Document

10.1007/978-94-011-4554-1_10

Cite this

Reinhoudt, D. N., Timmerman, P., Cardullo, F., & Crego-Calama, M. (1999). Synthesis and Characterization of hydrogen-bonded assemblies: toward the generation of binding site diversity. In R. Ungaro, & E. Dalcanale (Eds.), Supramolecular Science: Where It Is and Where It Is Going (pp. 181-195). (Nato Science Series C; Vol. 527). Kluwer Academic Publishers. https://doi.org/10.1007/978-94-011-4554-1_10

@inbook{4e7c72b8d07f4f49b6ba621ddf6f30ef,

title = "Synthesis and Characterization of hydrogen-bonded assemblies: toward the generation of binding site diversity",

abstract = "Discrete assemblies of nano-size dimensions were synthesized by non-covalent chemistry. Calix[4]arenes, diametrically substituted at the upper rim with two melamine units, form stable box-like assemblies in solution in the presence of two equivalents of 5,5-diethylbarbituric acid (DEB). Various techniques, such as NMR spectroscopy, MALDI-TOF mass spectrometry, and X-rays crystallography have been used for the characterization of these assemblies held together by 36 hydrogen bonds. Furthermore, assemblies with different types of functionalities at the upper rim of the calix[4]arene and at the melamine units were prepared. The effect of these functional groups on the stability of the assembly has been investigated. Small libraries of functionalized assemblies were formed by mixing the individual components under thermodynamically controlled conditions. This strategy provides access to functional group diversity.",

author = "Reinhoudt, \{David N.\} and P. Timmerman and F. Cardullo and M. Crego-Calama",

year = "1999",

doi = "10.1007/978-94-011-4554-1\_10",

language = "English",

isbn = "978-0-7923-5656-1",

series = "Nato Science Series C",

publisher = "Kluwer Academic Publishers",

pages = "181--195",

editor = "Rocco Ungaro and Enrico Dalcanale",

booktitle = "Supramolecular Science",

address = "Netherlands",

}

Reinhoudt, DN, Timmerman, P, Cardullo, F & Crego-Calama, M 1999, Synthesis and Characterization of hydrogen-bonded assemblies: toward the generation of binding site diversity. in R Ungaro & E Dalcanale (eds), Supramolecular Science: Where It Is and Where It Is Going. Nato Science Series C, vol. 527, Kluwer Academic Publishers, Dordrecht, pp. 181-195. https://doi.org/10.1007/978-94-011-4554-1_10

Synthesis and Characterization of hydrogen-bonded assemblies: toward the generation of binding site diversity. / Reinhoudt, David N.; Timmerman, P.; Cardullo, F. et al.
Supramolecular Science: Where It Is and Where It Is Going. ed. / Rocco Ungaro; Enrico Dalcanale. Dordrecht: Kluwer Academic Publishers, 1999. p. 181-195 (Nato Science Series C; Vol. 527).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

TY - CHAP

T1 - Synthesis and Characterization of hydrogen-bonded assemblies

T2 - toward the generation of binding site diversity

AU - Reinhoudt, David N.

AU - Timmerman, P.

AU - Cardullo, F.

AU - Crego-Calama, M.

PY - 1999

Y1 - 1999

N2 - Discrete assemblies of nano-size dimensions were synthesized by non-covalent chemistry. Calix[4]arenes, diametrically substituted at the upper rim with two melamine units, form stable box-like assemblies in solution in the presence of two equivalents of 5,5-diethylbarbituric acid (DEB). Various techniques, such as NMR spectroscopy, MALDI-TOF mass spectrometry, and X-rays crystallography have been used for the characterization of these assemblies held together by 36 hydrogen bonds. Furthermore, assemblies with different types of functionalities at the upper rim of the calix[4]arene and at the melamine units were prepared. The effect of these functional groups on the stability of the assembly has been investigated. Small libraries of functionalized assemblies were formed by mixing the individual components under thermodynamically controlled conditions. This strategy provides access to functional group diversity.

AB - Discrete assemblies of nano-size dimensions were synthesized by non-covalent chemistry. Calix[4]arenes, diametrically substituted at the upper rim with two melamine units, form stable box-like assemblies in solution in the presence of two equivalents of 5,5-diethylbarbituric acid (DEB). Various techniques, such as NMR spectroscopy, MALDI-TOF mass spectrometry, and X-rays crystallography have been used for the characterization of these assemblies held together by 36 hydrogen bonds. Furthermore, assemblies with different types of functionalities at the upper rim of the calix[4]arene and at the melamine units were prepared. The effect of these functional groups on the stability of the assembly has been investigated. Small libraries of functionalized assemblies were formed by mixing the individual components under thermodynamically controlled conditions. This strategy provides access to functional group diversity.

U2 - 10.1007/978-94-011-4554-1_10

DO - 10.1007/978-94-011-4554-1_10

M3 - Chapter

SN - 978-0-7923-5656-1

SN - 978-94-010-5933-6

T3 - Nato Science Series C

SP - 181

EP - 195

BT - Supramolecular Science

A2 - Ungaro, Rocco

A2 - Dalcanale, Enrico

PB - Kluwer Academic Publishers

CY - Dordrecht

ER -

Reinhoudt DN, Timmerman P, Cardullo F, Crego-Calama M. Synthesis and Characterization of hydrogen-bonded assemblies: toward the generation of binding site diversity. In Ungaro R, Dalcanale E, editors, Supramolecular Science: Where It Is and Where It Is Going. Dordrecht: Kluwer Academic Publishers. 1999. p. 181-195. (Nato Science Series C). doi: 10.1007/978-94-011-4554-1_10

Synthesis and Characterization of hydrogen-bonded assemblies: toward the generation of binding site diversity

Abstract

Publication series

Access to Document

Fingerprint

Cite this