Synthesis and noncovalent protein conjugation of linear-hyperbranched PEG-poly(glycerol) α,ωn-telechelics

Frederik Wurm, Johannes Klos, Hans Joachim Räder, Holger Frey*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

102 Citations (Scopus)

Abstract

(Figure Presented) Linear-hyperbranched, heterobifunctional α,ωn telechelic block copolymers consisting of a linear poly(ethylene glycol) (PEG) chain and a hyperbranched polyglycerol (PG) block have been prepared in five steps, using a protected amino-functional initiator. The polyfunctionality ωn (OH groups) can be adjusted by the degree of polymerization (DPn) of the polyglycerol block. Subsequent introduction of a single biotin unit by amidation in α-position permitted noncovalent bioconjugation with avidin.

Original languageEnglish
Pages (from-to)7954-7955
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number23
DOIs
Publication statusPublished - 17 Jun 2009
Externally publishedYes

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