Synthesis and noncovalent protein conjugation of linear-hyperbranched PEG-poly(glycerol) α,ωn-telechelics

Frederik Wurm; Johannes Klos; Hans Joachim Räder; Holger Frey

doi:10.1021/ja9019148

Synthesis and noncovalent protein conjugation of linear-hyperbranched PEG-poly(glycerol) α,ω_n-telechelics

Frederik Wurm, Johannes Klos, Hans Joachim Räder, Holger Frey^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

109 Citations (Scopus)

Abstract

(Figure Presented) Linear-hyperbranched, heterobifunctional α,ω_n telechelic block copolymers consisting of a linear poly(ethylene glycol) (PEG) chain and a hyperbranched polyglycerol (PG) block have been prepared in five steps, using a protected amino-functional initiator. The polyfunctionality ω_n (OH groups) can be adjusted by the degree of polymerization (DP_n) of the polyglycerol block. Subsequent introduction of a single biotin unit by amidation in α-position permitted noncovalent bioconjugation with avidin.

Original language	English
Pages (from-to)	7954-7955
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	131
Issue number	23
DOIs	https://doi.org/10.1021/ja9019148
Publication status	Published - 17 Jun 2009
Externally published	Yes

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abstract = "(Figure Presented) Linear-hyperbranched, heterobifunctional α,ωn telechelic block copolymers consisting of a linear poly(ethylene glycol) (PEG) chain and a hyperbranched polyglycerol (PG) block have been prepared in five steps, using a protected amino-functional initiator. The polyfunctionality ωn (OH groups) can be adjusted by the degree of polymerization (DPn) of the polyglycerol block. Subsequent introduction of a single biotin unit by amidation in α-position permitted noncovalent bioconjugation with avidin.",

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T1 - Synthesis and noncovalent protein conjugation of linear-hyperbranched PEG-poly(glycerol) α,ωn-telechelics

AU - Wurm, Frederik

AU - Klos, Johannes

AU - Räder, Hans Joachim

AU - Frey, Holger

PY - 2009/6/17

Y1 - 2009/6/17

N2 - (Figure Presented) Linear-hyperbranched, heterobifunctional α,ωn telechelic block copolymers consisting of a linear poly(ethylene glycol) (PEG) chain and a hyperbranched polyglycerol (PG) block have been prepared in five steps, using a protected amino-functional initiator. The polyfunctionality ωn (OH groups) can be adjusted by the degree of polymerization (DPn) of the polyglycerol block. Subsequent introduction of a single biotin unit by amidation in α-position permitted noncovalent bioconjugation with avidin.

AB - (Figure Presented) Linear-hyperbranched, heterobifunctional α,ωn telechelic block copolymers consisting of a linear poly(ethylene glycol) (PEG) chain and a hyperbranched polyglycerol (PG) block have been prepared in five steps, using a protected amino-functional initiator. The polyfunctionality ωn (OH groups) can be adjusted by the degree of polymerization (DPn) of the polyglycerol block. Subsequent introduction of a single biotin unit by amidation in α-position permitted noncovalent bioconjugation with avidin.

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IS - 23

ER -

Synthesis and noncovalent protein conjugation of linear-hyperbranched PEG-poly(glycerol) α,ω_n-telechelics

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