Regenerative medicine aims at replacing, engineering or regenerating human cells and tissues. There is a need for novel biomaterials to function as a temporal replacement of damaged tissues or organs. Synthetic biodegradable polymer networks can be such materials, since they offer benefits such as superior mechanical properties and the ease of tailoring physical properties when compared to natural materials. The selection of new polymeric biomaterial candidates can be accelerated by combinatorial chemistry, a very efficient strategy to obtain new materials with desired characteristics that could never be designed using conventional synthesis methods. This thesis presents the results of research on the photo-crosslinking of combinatorial mixtures of di-methacrylate functionalized PTMC, PDLLA, PCL and PEG oligomers.