Synthesis, characterization and in vitro toxicity of paramagnetic Au nanorods

Jealemy Galindo Millan, Jordi Cabanas Danés, David Reinhoudt, Pascal Jonkheijm, M.S.T. Koay, Jurriaan Huskens, Aldrik Velders, Jeroen Johannes Lambertus Maria Cornelissen

Research output: Contribution to conferenceAbstractOther research output

5 Downloads (Pure)

Abstract

Coated Au nanorods are widely known for their absorption in the near infrared1, making them excellent candidates for near infrared imaging and photo thermal therapy2. Furthermore, recent studies have shown that these nanomaterials are excellent candidates for Magnetic Resonance Imaging (MRI) since they can be used as T1 contrast agents when functionalized with Gd3+-containing moieties and as multimodal agents for MR-CT3 and MR-plasmonic4 imaging. In this context, our aim is to explore the possible incorporation of Gd3+ complexes to these nanosystems in order to use them as T1 contrast agents for MRI and, in a more advanced stage, as multimodal imaging agents. Here we describe the synthesis, characterization, properties and in vitro toxicity of paramagnetic nanorods coated, in one step, with combinations of thiol functionalized Gd3+ complexes of a 1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid) (DO3A)-based ligand and polyethylene glycol (PEG). Preliminary results show that these paramagnetic Au nanorods are biocompatible, show T1 contrast at low Gd3+ concentrations and are envisioned to become excellent candidates for multimodal purposes.
Original languageEnglish
Pages-
Number of pages1
Publication statusPublished - 25 Mar 2012
Event243rd ACS National Meeting & Exposition 2012: Chemistry of Life - San Diego, United States
Duration: 25 Mar 201229 Mar 2012
Conference number: 243

Conference

Conference243rd ACS National Meeting & Exposition 2012
CountryUnited States
CitySan Diego
Period25/03/1229/03/12

Fingerprint

Nanorods
Toxicity
Contrast Media
Nanosystems
Imaging techniques
Infrared imaging
Sulfhydryl Compounds
Nanostructured materials
Acetic Acid
Ligands
Magnetic Resonance Imaging

Keywords

  • METIS-293515
  • IR-85024

Cite this

Galindo Millan, J., Cabanas Danés, J., Reinhoudt, D., Jonkheijm, P., Koay, M. S. T., Huskens, J., ... Cornelissen, J. J. L. M. (2012). Synthesis, characterization and in vitro toxicity of paramagnetic Au nanorods. -. Abstract from 243rd ACS National Meeting & Exposition 2012, San Diego, United States.
Galindo Millan, Jealemy ; Cabanas Danés, Jordi ; Reinhoudt, David ; Jonkheijm, Pascal ; Koay, M.S.T. ; Huskens, Jurriaan ; Velders, Aldrik ; Cornelissen, Jeroen Johannes Lambertus Maria. / Synthesis, characterization and in vitro toxicity of paramagnetic Au nanorods. Abstract from 243rd ACS National Meeting & Exposition 2012, San Diego, United States.1 p.
@conference{b8c58dcb2c804a46a167b6469bd01392,
title = "Synthesis, characterization and in vitro toxicity of paramagnetic Au nanorods",
abstract = "Coated Au nanorods are widely known for their absorption in the near infrared1, making them excellent candidates for near infrared imaging and photo thermal therapy2. Furthermore, recent studies have shown that these nanomaterials are excellent candidates for Magnetic Resonance Imaging (MRI) since they can be used as T1 contrast agents when functionalized with Gd3+-containing moieties and as multimodal agents for MR-CT3 and MR-plasmonic4 imaging. In this context, our aim is to explore the possible incorporation of Gd3+ complexes to these nanosystems in order to use them as T1 contrast agents for MRI and, in a more advanced stage, as multimodal imaging agents. Here we describe the synthesis, characterization, properties and in vitro toxicity of paramagnetic nanorods coated, in one step, with combinations of thiol functionalized Gd3+ complexes of a 1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid) (DO3A)-based ligand and polyethylene glycol (PEG). Preliminary results show that these paramagnetic Au nanorods are biocompatible, show T1 contrast at low Gd3+ concentrations and are envisioned to become excellent candidates for multimodal purposes.",
keywords = "METIS-293515, IR-85024",
author = "{Galindo Millan}, Jealemy and {Cabanas Dan{\'e}s}, Jordi and David Reinhoudt and Pascal Jonkheijm and M.S.T. Koay and Jurriaan Huskens and Aldrik Velders and Cornelissen, {Jeroen Johannes Lambertus Maria}",
year = "2012",
month = "3",
day = "25",
language = "English",
pages = "--",
note = "243rd ACS National Meeting & Exposition 2012 : Chemistry of Life ; Conference date: 25-03-2012 Through 29-03-2012",

}

Galindo Millan, J, Cabanas Danés, J, Reinhoudt, D, Jonkheijm, P, Koay, MST, Huskens, J, Velders, A & Cornelissen, JJLM 2012, 'Synthesis, characterization and in vitro toxicity of paramagnetic Au nanorods' 243rd ACS National Meeting & Exposition 2012, San Diego, United States, 25/03/12 - 29/03/12, pp. -.

Synthesis, characterization and in vitro toxicity of paramagnetic Au nanorods. / Galindo Millan, Jealemy; Cabanas Danés, Jordi; Reinhoudt, David; Jonkheijm, Pascal; Koay, M.S.T.; Huskens, Jurriaan; Velders, Aldrik; Cornelissen, Jeroen Johannes Lambertus Maria.

2012. - Abstract from 243rd ACS National Meeting & Exposition 2012, San Diego, United States.

Research output: Contribution to conferenceAbstractOther research output

TY - CONF

T1 - Synthesis, characterization and in vitro toxicity of paramagnetic Au nanorods

AU - Galindo Millan, Jealemy

AU - Cabanas Danés, Jordi

AU - Reinhoudt, David

AU - Jonkheijm, Pascal

AU - Koay, M.S.T.

AU - Huskens, Jurriaan

AU - Velders, Aldrik

AU - Cornelissen, Jeroen Johannes Lambertus Maria

PY - 2012/3/25

Y1 - 2012/3/25

N2 - Coated Au nanorods are widely known for their absorption in the near infrared1, making them excellent candidates for near infrared imaging and photo thermal therapy2. Furthermore, recent studies have shown that these nanomaterials are excellent candidates for Magnetic Resonance Imaging (MRI) since they can be used as T1 contrast agents when functionalized with Gd3+-containing moieties and as multimodal agents for MR-CT3 and MR-plasmonic4 imaging. In this context, our aim is to explore the possible incorporation of Gd3+ complexes to these nanosystems in order to use them as T1 contrast agents for MRI and, in a more advanced stage, as multimodal imaging agents. Here we describe the synthesis, characterization, properties and in vitro toxicity of paramagnetic nanorods coated, in one step, with combinations of thiol functionalized Gd3+ complexes of a 1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid) (DO3A)-based ligand and polyethylene glycol (PEG). Preliminary results show that these paramagnetic Au nanorods are biocompatible, show T1 contrast at low Gd3+ concentrations and are envisioned to become excellent candidates for multimodal purposes.

AB - Coated Au nanorods are widely known for their absorption in the near infrared1, making them excellent candidates for near infrared imaging and photo thermal therapy2. Furthermore, recent studies have shown that these nanomaterials are excellent candidates for Magnetic Resonance Imaging (MRI) since they can be used as T1 contrast agents when functionalized with Gd3+-containing moieties and as multimodal agents for MR-CT3 and MR-plasmonic4 imaging. In this context, our aim is to explore the possible incorporation of Gd3+ complexes to these nanosystems in order to use them as T1 contrast agents for MRI and, in a more advanced stage, as multimodal imaging agents. Here we describe the synthesis, characterization, properties and in vitro toxicity of paramagnetic nanorods coated, in one step, with combinations of thiol functionalized Gd3+ complexes of a 1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid) (DO3A)-based ligand and polyethylene glycol (PEG). Preliminary results show that these paramagnetic Au nanorods are biocompatible, show T1 contrast at low Gd3+ concentrations and are envisioned to become excellent candidates for multimodal purposes.

KW - METIS-293515

KW - IR-85024

M3 - Abstract

SP - -

ER -

Galindo Millan J, Cabanas Danés J, Reinhoudt D, Jonkheijm P, Koay MST, Huskens J et al. Synthesis, characterization and in vitro toxicity of paramagnetic Au nanorods. 2012. Abstract from 243rd ACS National Meeting & Exposition 2012, San Diego, United States.