Synthesis of monoalkylated calix[4]arenes via direct alkylation

Leo C. Groenen, L.C. Groenen, Bianca H.M. Ruel, Alessandro Casnati, Willem Verboom, Andrea Pochini

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Abstract

A new one-step procedure for the synthesis of monoalkylated calix[4]arenes is presented. Reaction of calix[4]arene 1a or 1b with 1.2 equivalent of a weak base (K2CO3 in MeCN or CsF in DMF) and excess of alkylating agent affords the monoalkylated calix[4]arenes in moderate to good yields
Original languageUndefined
Pages (from-to)8379-8384
Number of pages6
JournalTetrahedron
Volume0
Issue number47
DOIs
Publication statusPublished - 1991

Keywords

  • METIS-106725
  • IR-12544

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