Synthesis of monoalkylated calix[4]arenes via direct alkylation

Leo C. Groenen; L.C. Groenen; Bianca H.M. Ruel; Alessandro Casnati; Willem Verboom; Andrea Pochini

doi:10.1016/S0040-4020(01)96179-4

Synthesis of monoalkylated calix[4]arenes via direct alkylation

Leo C. Groenen, L.C. Groenen, Bianca H.M. Ruel, Alessandro Casnati, Willem Verboom, Andrea Pochini

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Abstract

A new one-step procedure for the synthesis of monoalkylated calix[4]arenes is presented. Reaction of calix[4]arene 1a or 1b with 1.2 equivalent of a weak base (K2CO3 in MeCN or CsF in DMF) and excess of alkylating agent affords the monoalkylated calix[4]arenes in moderate to good yields

Original language	Undefined
Pages (from-to)	8379-8384
Number of pages	6
Journal	Tetrahedron
Volume	0
Issue number	47
DOIs	https://doi.org/10.1016/S0040-4020(01)96179-4
Publication status	Published - 1991

Keywords

METIS-106725
IR-12544

Access to Document

10.1016/S0040-4020(01)96179-4

Groenen91synthesis
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Cite this

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title = "Synthesis of monoalkylated calix[4]arenes via direct alkylation",

abstract = "A new one-step procedure for the synthesis of monoalkylated calix[4]arenes is presented. Reaction of calix[4]arene 1a or 1b with 1.2 equivalent of a weak base (K2CO3 in MeCN or CsF in DMF) and excess of alkylating agent affords the monoalkylated calix[4]arenes in moderate to good yields",

keywords = "METIS-106725, IR-12544",

author = "Groenen, {Leo C.} and L.C. Groenen and Ruel, {Bianca H.M.} and Alessandro Casnati and Willem Verboom and Andrea Pochini",

year = "1991",

doi = "10.1016/S0040-4020(01)96179-4",

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volume = "0",

pages = "8379--8384",

journal = "Tetrahedron",

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T1 - Synthesis of monoalkylated calix[4]arenes via direct alkylation

AU - Groenen, Leo C.

AU - Groenen, L.C.

AU - Ruel, Bianca H.M.

AU - Casnati, Alessandro

AU - Verboom, Willem

AU - Pochini, Andrea

PY - 1991

Y1 - 1991

N2 - A new one-step procedure for the synthesis of monoalkylated calix[4]arenes is presented. Reaction of calix[4]arene 1a or 1b with 1.2 equivalent of a weak base (K2CO3 in MeCN or CsF in DMF) and excess of alkylating agent affords the monoalkylated calix[4]arenes in moderate to good yields

AB - A new one-step procedure for the synthesis of monoalkylated calix[4]arenes is presented. Reaction of calix[4]arene 1a or 1b with 1.2 equivalent of a weak base (K2CO3 in MeCN or CsF in DMF) and excess of alkylating agent affords the monoalkylated calix[4]arenes in moderate to good yields

KW - METIS-106725

KW - IR-12544

U2 - 10.1016/S0040-4020(01)96179-4

DO - 10.1016/S0040-4020(01)96179-4

M3 - Article

VL - 0

SP - 8379

EP - 8384

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 47

ER -