Synthesis of neutral, water-soluble calix[4]arenes

M.H.B. Grote gansey, Marcel H.B. Grote Gansey, Frank J. Steemers, F.J. Steemers, Willem Verboom, David Reinhoudt

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Abstract

Novel neutral water-soluble calix[4]arenes were synthesized via chlorosulfonylation of lower rim functionalized calix[4]arenes followed by reaction with hydroxyl group containing amines. The solubility of these calix[4]arenes sulfonamides in water varies from ∼ 10-5 to 3.1⋅10-1 M. A route via hydrophobically protected amines improves the purification.
Original languageUndefined
Pages (from-to)643-648
JournalSynthesis (Germany)
Volume1997
Issue number6
DOIs
Publication statusPublished - 1997

Keywords

  • IR-11125
  • METIS-106006

Cite this

Grote gansey, M. H. B., Grote Gansey, M. H. B., Steemers, F. J., Steemers, F. J., Verboom, W., & Reinhoudt, D. (1997). Synthesis of neutral, water-soluble calix[4]arenes. Synthesis (Germany), 1997(6), 643-648. https://doi.org/10.1055/s-1997-4506