Novel neutral water-soluble calixarenes were synthesized via chlorosulfonylation of lower rim functionalized calixarenes followed by reaction with hydroxyl group containing amines. The solubility of these calixarenes sulfonamides in water varies from ∼ 10-5 to 3.1⋅10-1 M. A route via hydrophobically protected amines improves the purification.
Grote gansey, M. H. B., Grote Gansey, M. H. B., Steemers, F. J., Steemers, F. J., Verboom, W., & Reinhoudt, D. (1997). Synthesis of neutral, water-soluble calixarenes. Synthesis (Germany), 1997(6), 643-648. https://doi.org/10.1055/s-1997-4506