Synthesis of neutral, water-soluble calix[4]arenes

M.H.B. Grote gansey, Marcel H.B. Grote Gansey, Frank J. Steemers, F.J. Steemers, Willem Verboom, David Reinhoudt

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Novel neutral water-soluble calix[4]arenes were synthesized via chlorosulfonylation of lower rim functionalized calix[4]arenes followed by reaction with hydroxyl group containing amines. The solubility of these calix[4]arenes sulfonamides in water varies from ∼ 10-5 to 3.1⋅10-1 M. A route via hydrophobically protected amines improves the purification.
Original languageUndefined
Pages (from-to)643-648
JournalSynthesis (Germany)
Issue number6
Publication statusPublished - 1997


  • IR-11125
  • METIS-106006

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