Synthesis tool for separation processes in the pharmaceutical industry

Ana I.C. Morão*, Edwin Zondervan, Gerard Krooshof, Rob Geertman, André B. de Haan

*Corresponding author for this work

Research output: Contribution to journalConference articleAcademicpeer-review

1 Citation (Scopus)


A synthesis tool to select promising separation routes to purify active pharmaceutical ingredients is introduced in this paper. It combines heuristics with flowsheet simulations to systematically generate and compare alternatives. The application of this framework to the purification of progesterone led to new insights that must be confirmed by experiments.

Original languageEnglish
Pages (from-to)276-280
Number of pages5
JournalComputer Aided Chemical Engineering
Publication statusPublished - 2011
Externally publishedYes
Event21st European Symposium on Computer Aided Process Engineering - Porto Carras Resort, Chalkidiki, Greece
Duration: 29 May 20111 Jun 2011


  • Pharmaceutical industry
  • Process design
  • Process synthesis

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