Synthesis tool for separation processes in the pharmaceutical industry

Ana I.C. Morão; Edwin Zondervan; Gerard Krooshof; Rob Geertman; André B. de Haan

doi:10.1016/B978-0-444-53711-9.50056-0

Synthesis tool for separation processes in the pharmaceutical industry

Ana I.C. Morão^*, Edwin Zondervan, Gerard Krooshof, Rob Geertman, André B. de Haan

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › Academic › peer-review

1 Citation (Scopus)

Abstract

A synthesis tool to select promising separation routes to purify active pharmaceutical ingredients is introduced in this paper. It combines heuristics with flowsheet simulations to systematically generate and compare alternatives. The application of this framework to the purification of progesterone led to new insights that must be confirmed by experiments.

Original language	English
Pages (from-to)	276-280
Number of pages	5
Journal	Computer Aided Chemical Engineering
Volume	29
DOIs	https://doi.org/10.1016/B978-0-444-53711-9.50056-0
Publication status	Published - 2011
Externally published	Yes
Event	21st European Symposium on Computer Aided Process Engineering - Porto Carras Resort, Chalkidiki, Greece Duration: 29 May 2011 → 1 Jun 2011

Keywords

Pharmaceutical industry
Process design
Process synthesis

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10.1016/B978-0-444-53711-9.50056-0

Cite this

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title = "Synthesis tool for separation processes in the pharmaceutical industry",

abstract = "A synthesis tool to select promising separation routes to purify active pharmaceutical ingredients is introduced in this paper. It combines heuristics with flowsheet simulations to systematically generate and compare alternatives. The application of this framework to the purification of progesterone led to new insights that must be confirmed by experiments.",

keywords = "Pharmaceutical industry, Process design, Process synthesis",

author = "Mor{\~a}o, {Ana I.C.} and Edwin Zondervan and Gerard Krooshof and Rob Geertman and {de Haan}, {Andr{\'e} B.}",

year = "2011",

doi = "10.1016/B978-0-444-53711-9.50056-0",

language = "English",

volume = "29",

pages = "276--280",

journal = "Computer Aided Chemical Engineering",

issn = "1570-7946",

publisher = "Elsevier B.V.",

note = "21st European Symposium on Computer Aided Process Engineering, ESCAPE 2011 ; Conference date: 29-05-2011 Through 01-06-2011",

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T1 - Synthesis tool for separation processes in the pharmaceutical industry

AU - Morão, Ana I.C.

AU - Zondervan, Edwin

AU - Krooshof, Gerard

AU - Geertman, Rob

AU - de Haan, André B.

PY - 2011

Y1 - 2011

N2 - A synthesis tool to select promising separation routes to purify active pharmaceutical ingredients is introduced in this paper. It combines heuristics with flowsheet simulations to systematically generate and compare alternatives. The application of this framework to the purification of progesterone led to new insights that must be confirmed by experiments.

AB - A synthesis tool to select promising separation routes to purify active pharmaceutical ingredients is introduced in this paper. It combines heuristics with flowsheet simulations to systematically generate and compare alternatives. The application of this framework to the purification of progesterone led to new insights that must be confirmed by experiments.

KW - Pharmaceutical industry

KW - Process design

KW - Process synthesis

UR - http://www.scopus.com/inward/record.url?scp=79958836260&partnerID=8YFLogxK

U2 - 10.1016/B978-0-444-53711-9.50056-0

DO - 10.1016/B978-0-444-53711-9.50056-0

M3 - Conference article

AN - SCOPUS:79958836260

SN - 1570-7946

VL - 29

SP - 276

EP - 280

JO - Computer Aided Chemical Engineering

JF - Computer Aided Chemical Engineering

T2 - 21st European Symposium on Computer Aided Process Engineering

Y2 - 29 May 2011 through 1 June 2011

ER -

Synthesis tool for separation processes in the pharmaceutical industry

Abstract

Keywords

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